Gene Symbol: nox5
Description: NADPH oxidase, EF-hand calcium binding domain 5
Alias: si:ch1073-365g6.1, NADPH oxidase 5, zmp:0000000874
Species: zebrafish

Top Publications

  1. Niethammer P, Grabher C, Look A, Mitchison T. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009;459:996-9 pubmed publisher
    ..This is the first observation, to our knowledge, of a tissue-scale H(2)O(2) pattern, and the first evidence that H(2)O(2) signals to leukocytes in tissues, in addition to its known antiseptic role. ..
  2. Yan B, Han P, Pan L, Lu W, Xiong J, Zhang M, et al. IL-1? and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model. J Immunol. 2014;192:5998-6008 pubmed publisher
    ..In addition, Il-1? overexpressing Tg(hsp70:(m)il-1?_eGFP;lyz:DsRed2)hkz10t;nz50 transgenic zebrafish provides a useful animal model for the study of chronic inflammatory disorder and for anti-inflammatory drug discovery. ..
  3. Han P, Zhou X, Chang N, Xiao C, Yan S, Ren H, et al. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Res. 2014;24:1091-107 pubmed publisher
    ..We conclude that H2O2 potentially generated from Duox/Nox2 promotes heart regeneration in zebrafish by unleashing MAP kinase signaling through a derepression mechanism involving Dusp6. ..
  4. Weaver C, Leung Y, Suter D. Expression dynamics of NADPH oxidases during early zebrafish development. J Comp Neurol. 2016;524:2130-41 pubmed publisher
    ..Although the sequences of five NOX genes (nox1, nox2/cybb, nox4, nox5, and duox) have been identified in the zebrafish genome, nothing is known about their expression pattern...