Gene Symbol: nox1
Description: NADPH oxidase 1
Alias: NADPH oxidase 1
Han P, Zhou X, Chang N, Xiao C, Yan S, Ren H, et al
. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Res. 2014;24:1091-107 pubmed publisher
..We conclude that H2O2 potentially generated from Duox/Nox2 promotes heart regeneration in zebrafish by unleashing MAP kinase signaling through a derepression mechanism involving Dusp6. ..
Wu Y, Huang S, Nan F, Chang C, Hsiao C, Lai K, et al
. Over-inhibition of NADPH oxidase reduce the wound healing in liver of finfish. Fish Shellfish Immunol. 2014;40:174-81 pubmed publisher
..We conclude that over inhibition of the NADPH oxidase by DPI may reduce the cell even the tissue in the progress of healing after the injury. ..
Liu H, Sheng N, Zhang W, Dai J. Toxic effects of perfluorononanoic acid on the development of Zebrafish (Danio rerio) embryos. J Environ Sci (China). 2015;32:26-34 pubmed publisher
..However, the mRNA expression levels of both ppara and pparg did not show any significant variation after exposure. These findings suggest that PFNA affected the development of zebrafish embryos at relatively low concentrations. ..
Weaver C, Leung Y, Suter D. Expression dynamics of NADPH oxidases during early zebrafish development. J Comp Neurol. 2016;524:2130-41 pubmed publisher
..Although the sequences of five NOX genes (nox1, nox2/cybb, nox4, nox5, and duox) have been identified in the zebrafish genome, nothing is known about their ..
Kawahara T, Lambeth J. Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol. 2007;7:178 pubmed
..and Nox-activator 1 (NOXA1), respective homologs of p47phox and p67phox, together with p22phox and Rac, activate Nox1, a non-phagocytic homolog of Nox2. NOXO1 and p22phox also regulate Nox3, whereas Nox4 requires only p22phox...
Razaghi B, Steele S, Prykhozhij S, Stoyek M, Hill J, Cooper M, et al
. hace1 Influences zebrafish cardiac development via ROS-dependent mechanisms. Dev Dyn. 2018;247:289-303 pubmed publisher
..this phenotype appears to be directly related to Nox enzyme-dependent ROS production, as both genetic inhibition by nox1 and nox2 morpholinos or pharmacologic rescue using ROS scavenging agents restores normal cardiac structure...