not really finished


Gene Symbol: not really finished
Description: nuclear respiratory factor 1
Alias: SC:BZ3C13.1, SC:bZ3C13.2, ube2h, nuclear respiratory factor 1, not really finished protein, nrf, nrf-1, nrl
Species: zebrafish
Products:     not really finished

Top Publications

  1. Bremer K, Kocha K, Snider T, Moyes C. Sensing and responding to energetic stress: The role of the AMPK-PGC1α-NRF1 axis in control of mitochondrial biogenesis in fish. Comp Biochem Physiol B Biochem Mol Biol. 2016;199:4-12 pubmed publisher
    ..metabolic genes through direct and indirect association with DNA-binding proteins such as the nuclear respiratory factor 1 (NRF1) (Wu et al., 1999)...
  2. Little A, Kunisue T, Kannan K, Seebacher F. Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio). BMC Biol. 2013;11:26 pubmed publisher
    ..We suggest that the properties that underlie the role of TH in thermal acclimation (temperature sensitivity and metabolic control) may have predisposed this hormone for a regulatory role in the evolution of endothermy. ..
  3. Long Y, Song G, Yan J, He X, Li Q, Cui Z. Transcriptomic characterization of cold acclimation in larval zebrafish. BMC Genomics. 2013;14:612 pubmed publisher
    ..These findings indicate that zebrafish larvae possess the ability to build cold-tolerance under mild low temperature and transcriptional and post-transcriptional regulations are extensively involved in this acclimation process. ..
  4. Chen D, Li F, Yang Q, Tian M, Zhang Z, Zhang Q, et al. The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish. Int J Biochem Cell Biol. 2016;77:1-9 pubmed publisher
    ..In addition, this zebrafish model of mitochondrial disease may provide unique opportunities for studying defective tRNA modification, mitochondrial biogenesis, and pathophysiology of mitochondrial disorders. ..
  5. Becker T, Burgess S, Amsterdam A, Allende M, Hopkins N. not really finished is crucial for development of the zebrafish outer retina and encodes a transcription factor highly homologous to human Nuclear Respiratory Factor-1 and avian Initiation Binding Repressor. Development. 1998;125:4369-78 pubmed
    ..The protein encoded by nrf is a close homologue of human Nuclear Respiratory Factor 1 and avian Initiation Binding Repressor, transcriptional regulators binding the upstream consensus ..
  6. McClelland G, Craig P, Dhekney K, Dipardo S. Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). J Physiol. 2006;577:739-51 pubmed
    ..Both treatments showed increases in nuclear respiratory factor (NRF)-1 mRNA which was increased by 2.3x in cold-acclimatized and 4x in exercise-trained zebrafish above controls...
  7. Masuda T, Wada Y, Kawamura S. ES1 is a mitochondrial enlarging factor contributing to form mega-mitochondria in zebrafish cones. Sci Rep. 2016;6:22360 pubmed publisher
    ..ES1 is the mitochondrial protein that is first found to promote enlargement of individual mitochondria. ..
  8. Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, et al. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014;4:3708 pubmed publisher
    ..eriocitrin increased mRNA of mitochondrial biogenesis genes, such as mitochondria transcription factor, nuclear respiratory factor 1, cytochrome c oxidase subunit 4, and ATP synthase...
  9. Hasumura T, Meguro S. Exercise quantity-dependent muscle hypertrophy in adult zebrafish (Danio rerio). J Comp Physiol B. 2016;186:603-14 pubmed publisher
    ..These results open up the possibility for further investigations on the effects of exercise on skeletal muscle in adult zebrafish. ..

More Information


  1. Peng X, Shang G, Wang W, Chen X, Lou Q, Zhai G, et al. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3. Cell Rep. 2017;19:1444-1455 pubmed publisher
    ..Our results demonstrate that regulation of 1α,25(OH)2D3 during lipid metabolism occurs through the regulation of Pgc1a for mitochondrial biogenesis and oxidative metabolism within zebrafish VAT. ..