nos2b

Summary

Gene Symbol: nos2b
Description: nitric oxide synthase 2b, inducible
Alias: inosb, nitric oxide synthase, inducible, inducible nitric oxide synthase b
Species: zebrafish

Top Publications

  1. Parikka M, Hammarén M, Harjula S, Halfpenny N, Oksanen K, Lahtinen M, et al. Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish. PLoS Pathog. 2012;8:e1002944 pubmed publisher
    ..The possibilities for screening for host and pathogen factors affecting the disease progression, and identifying novel therapeutic agents and vaccine targets make this established model especially attractive...
  2. Lepiller S, Franche N, Solary E, Chluba J, Laurens V. Comparative analysis of zebrafish nos2a and nos2b genes. Gene. 2009;445:58-65 pubmed publisher
    ..In zebrafish genome, one nos1 gene and two nos2 genes (nos2a and nos2b) were observed. We cloned zebrafish nos2a cDNA and compared nos2a and nos2b sequences, expression and inducibility...
  3. Poon K, Richardson M, Korzh V. Expression of zebrafish nos2b surrounds oral cavity. Dev Dyn. 2008;237:1662-7 pubmed publisher
    ..In zebrafish, Nos2 is represented by nos2a and nos2b. Here, we report the cloning and expression pattern of the zebrafish nos2b gene, which does not seem to ..
  4. Hegedus Z, Zakrzewska A, Agoston V, Ordas A, Racz P, Mink M, et al. Deep sequencing of the zebrafish transcriptome response to mycobacterium infection. Mol Immunol. 2009;46:2918-30 pubmed publisher
  5. Yousfi N, Pruvot B, Lopez T, Magadoux L, Franche N, Pichon L, et al. The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model. PLoS ONE. 2015;10:e0120435 pubmed publisher
  6. Hammar n M, Oksanen K, Nisula H, Luukinen B, Pesu M, R met M, et al. Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog. 2014;10:e1004190 pubmed publisher
    ..Characteristic gata3/tbx21 has potential as a biomarker for the status of mycobacterial disease...
  7. Schall K, Thornton M, Isani M, Holoyda K, Hou X, Lien C, et al. Short bowel syndrome results in increased gene expression associated with proliferation, inflammation, bile acid synthesis and immune system activation: RNA sequencing a zebrafish SBS model. BMC Genomics. 2017;18:23 pubmed publisher
    ..Gene expression of ctnnb1, ccnb1, ccnd1, cyp7a1a, dkk3, ifng1-2, igf2a, il1b, lef1, nos2b, saa1, stat3, tnfa and wnt5a were confirmed to be elevated in SBS by RT-qPCR...
  8. López Muñoz A, Roca F, Meseguer J, Mulero V. New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. J Immunol. 2009;182:3440-9 pubmed publisher
    ..Collectively, our results suggest nonredundant, complementary roles of type I zfIFNs in viral infections and provide evidence for a pivotal role of the recently identified group II IFN of fish in the early stages of viral infections. ..
  9. Galindo Villegas J, García Moreno D, de Oliveira S, Meseguer J, Mulero V. Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proc Natl Acad Sci U S A. 2012;109:E2605-14 pubmed

More Information

Publications14

  1. Hsu A, Wang D, Gurol T, Zhou W, Zhu X, Lu H, et al. Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish. Dis Model Mech. 2017;10:1323-1332 pubmed publisher
    ..Finally, an miR-722 mimic protects zebrafish from lethal lipopolysaccharide challenge. Together, these results provide evidence for and the mechanism of an anti-inflammatory miRNA that restrains detrimental systemic inflammation. ..
  2. Corrales J, Fang X, Thornton C, Mei W, Barbazuk W, Duke M, et al. Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo[a]pyrene exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2014;163:37-46 pubmed publisher
    ..Further studies are needed to link aberrant CG, CHH, and CHG methylation to heritable epigenetic consequences associated with disease in later life. ..
  3. Vliegenthart A, Wei C, Buckley C, Berends C, de Potter C, Schneemann S, et al. Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model. Toxicol Sci. 2017;159:380-391 pubmed publisher
    ..RNA sequencing, guided by time-lapse microscopy, revealed early down-regulation of genes consistent with previous invitro studies, and facilitated the discovery of mechanistic inflammatory pathways. ..
  4. Wang L, Zhang P, Wei Y, Gao Y, Patient R, Liu F. A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 2011;118:4102-10 pubmed publisher
    ..Taken together, we have demonstrated that blood flow is essential for HSC development and is mediated by a klf2a-NO signaling cascade in zebrafish. ..
  5. Wittmann C, Reischl M, Shah A, Kronfuss E, Mikut R, Liebel U, et al. A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide. PLoS ONE. 2015;10:e0137286 pubmed publisher
    ..Together, we show that our screening method can help to identify novel immune-modulatory activities and provide new mechanistic insights into the regulation of inflammatory processes. ..