Gene Symbol: nos1
Description: nitric oxide synthase 1 (neuronal)
Alias: nNOS, nos, nitric oxide synthase, brain
Species: zebrafish
Products:     nos1

Top Publications

  1. Saito T, Goto Kazeto R, Fujimoto T, Kawakami Y, Arai K, Yamaha E. Inter-species transplantation and migration of primordial germ cells in cyprinid fish. Int J Dev Biol. 2010;54:1481-86 pubmed publisher
  2. Poon K, Richardson M, Lam C, Khoo H, Korzh V. Expression pattern of neuronal nitric oxide synthase in embryonic zebrafish. Gene Expr Patterns. 2003;3:463-6 pubmed
    ..Here, we report the cloning and expression pattern of the zebrafish nnos. This gene was mapped to zebrafish linkage group 5...
  3. Lepiller S, Franche N, Solary E, Chluba J, Laurens V. Comparative analysis of zebrafish nos2a and nos2b genes. Gene. 2009;445:58-65 pubmed publisher
    ..Three NOS isoforms have been identified in mammals, namely a neuronal (NOS1), an inducible (NOS2) and an endothelial (NOS3) enzyme...
  4. Olden T, Akhtar T, Beckman S, Wallace K. Differentiation of the zebrafish enteric nervous system and intestinal smooth muscle. Genesis. 2008;46:484-98 pubmed publisher
    ..Enteric precursors continue proliferating and differentiating into the third day of embryogenesis. nNOS neurons form early while serotonin neurons form late toward the end of enteric neural differentiation...
  5. Wang L, Zhang P, Wei Y, Gao Y, Patient R, Liu F. A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 2011;118:4102-10 pubmed publisher
    ..Furthermore, the expression of NO synthase (nos) was reduced in klf2a knockdown embryos, and ChIP analysis showed that endogenous Klf2a is bound to the promoters ..
  6. Pietsch J, Delalande J, Jakaitis B, Stensby J, Dohle S, Talbot W, et al. lessen encodes a zebrafish trap100 required for enteric nervous system development. Development. 2006;133:395-406 pubmed
    ..These studies demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of ENS precursors in the intestine. ..
  7. Xu H, Kardash E, Chen S, Raz E, Lin F. G?? signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Development. 2012;139:57-62 pubmed publisher
    ..Our results indicate that during PGC migration in vivo, G?? signaling regulates Rac activity to control cell polarity, which is required for the responsiveness to chemokine signaling. ..
  8. Kawakami Y, Goto Kazeto R, Saito T, Fujimoto T, Higaki S, Takahashi Y, et al. Generation of germ-line chimera zebrafish using primordial germ cells isolated from cultured blastomeres and cryopreserved embryoids. Int J Dev Biol. 2010;54:1493-501 pubmed publisher
    ..Offspring were obtained from natural spawning between normal females and chimeric males. These results provide the basis for new methods of gene preservation in zebrafish. ..
  9. Holmqvist B, Ellingsen B, Forsell J, Zhdanova I, Alm P. The early ontogeny of neuronal nitric oxide synthase systems in the zebrafish. J Exp Biol. 2004;207:923-35 pubmed
    To examine a putative role for neuronal nitric oxide synthase (nNOS) in early vertebrate development we investigated nNOS mRNA expression and cGMP production during development of the zebrafish Danio rerio...

More Information


  1. North T, Goessling W, Peeters M, Li P, Ceol C, Lord A, et al. Hematopoietic stem cell development is dependent on blood flow. Cell. 2009;137:736-48 pubmed publisher
    ..Morpholino knockdown of nos1 (nnos/enos) blocked HSC development, and its requirement was shown to be cell autonomous...
  2. Lo K, Hui M, Yu R, Wu R, Cheng S. Hypoxia impairs primordial germ cell migration in zebrafish (Danio rerio) embryos. PLoS ONE. 2011;6:e24540 pubmed publisher
    ..IGF signaling is shown to be one of the possible mechanisms for the causal link between hypoxia and PGC migration. We propose that hypoxia causes PGC migration defect by inhibiting IGF signaling through the induction of IGFBP-1. ..
  3. Wittmann C, Reischl M, Shah A, Kronfuss E, Mikut R, Liebel U, et al. A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide. PLoS ONE. 2015;10:e0137286 pubmed publisher
    ..Together, we show that our screening method can help to identify novel immune-modulatory activities and provide new mechanistic insights into the regulation of inflammatory processes. ..
  4. Westermann B, Meissl H. Nitric oxide synthase in photoreceptive pineal organs of fish. Comp Biochem Physiol A Mol Integr Physiol. 2008;151:198-204 pubmed publisher
    ..However, despite the significant rise in cGMP levels nitric oxide donors did neither affect acute light-dependent melatonin formation in the trout pineal nor the rhythmic production of melatonin in the zebrafish pineal. ..
  5. Xie L, Fang P, Lin J, Pan H, Zhang F, Shen Y. [Expression of gdnf and nos in adult zebrafish brain during the regeneration after spinal cord injury]. Yi Chuan. 2013;35:495-501 pubmed
    ..applied to reveal the dynamics of glial cell line-derived neurotrophic factor (gdnf) and nitric oxide synthases (nos) mRNA expression in various regions of zebrafish brain...
  6. Cox A, Saunders D, Kelsey P, Conway A, Tesmenitsky Y, Marchini J, et al. S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell Rep. 2014;6:56-69 pubmed publisher
    ..These studies demonstrate that GSNOR inhibitors will be beneficial therapeutic candidates for treating liver injury...
  7. Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty K, Lawson N. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 2010;464:1196-200 pubmed publisher
    ..Taken together, our work describes a novel genetic mechanism in which a microRNA facilitates integration of a physiological stimulus with growth factor signalling in endothelial cells to guide angiogenesis. ..
  8. Yousfi N, Pruvot B, Lopez T, Magadoux L, Franche N, Pichon L, et al. The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model. PLoS ONE. 2015;10:e0120435 pubmed publisher
  9. Bradley S, Tossell K, Lockley R, McDearmid J. Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons. J Neurosci. 2010;30:16818-31 pubmed publisher
    ..In the immature nervous system, the neuronal isoform of NOS (NOS1) is often expressed during periods of axon outgrowth and elaboration...
  10. Goto Kazeto R, Saito T, Takagi M, Arai K, Yamaha E. Isolation of teleost primordial germ cells using flow cytometry. Int J Dev Biol. 2010;54:1487-92 pubmed publisher
    ..In zebrafish, medaka and goldfish, the PGCs were labeled by injecting the gfp-nos1 3UTR mRNA into 1- 4 cell embryos...
  11. Bordieri L, Bonaccorsi di Patti M, Miele R, Cioni C. Partial cloning of neuronal nitric oxide synthase (nNOS) cDNA and regional distribution of nNOS mRNA in the central nervous system of the Nile tilapia Oreochromis niloticus. Brain Res Mol Brain Res. 2005;142:123-33 pubmed
    ..The predicted 206-long amino acid sequence showed a high degree of identity with other vertebrate neuronal NOS (nNOS) protein sequences...