Gene Symbol: nme2b.2
Description: NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2
Alias: NDPK-Z2, NM23-Z2, ndpkz2, nme2b2, nucleoside diphosphate kinase B, non-metastatic cells 2b.2, protein (NM23B) expressed in, nucleoside diphosphate kinase-Z2
Species: zebrafish

Top Publications

  1. Bilitou A, Watson J, Gartner A, Ohnuma S. The NM23 family in development. Mol Cell Biochem. 2009;329:17-33 pubmed publisher
    ..A more detailed understanding of the evolution of the family and its role in vertebrate development will facilitate elucidation of the mechanism of NM23 involvement in human cancer. ..
  2. Gómez Requeni P, Conceição L, Olderbakk Jordal A, Rønnestad I. A reference growth curve for nutritional experiments in zebrafish (Danio rerio) and changes in whole body proteome during development. Fish Physiol Biochem. 2010;36:1199-215 pubmed publisher
    ..Thus, in order to design nutritional studies with zebrafish fed Artemia nauplii, it is recommended to select a period between 20 and 40 dpf, when fish allocate most of the ingested energy for non-reproductive growth purposes. ..
  3. Cambier S, Gonzalez P, Durrieu G, Maury Brachet R, Boudou A, Bourdineaud J. Serial analysis of gene expression in the skeletal muscles of zebrafish fed with a methylmercury-contaminated diet. Environ Sci Technol. 2010;44:469-75 pubmed publisher
    ..Furthermore, this is the first time that the SAGE was used to characterize the effect of a toxicant at the genome scale in an aquatic organism. ..
  4. Doğanlı C, Beck H, Ribera A, Oxvig C, Lykke Hartmann K. ?3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish. J Biol Chem. 2013;288:8862-74 pubmed publisher
    ..Our data thus strongly support the role of ?3Na(+)/K(+)-ATPase in zebrafish motility and brain development, associating for the first time the ?3Na(+)/K(+)-ATPase deficiency with brain ventricle dilation. ..
  5. Feng Y, Gross S, Wolf N, Butenschön V, Qiu Y, Devraj K, et al. Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins. Arterioscler Thromb Vasc Biol. 2014;34:2292-300 pubmed publisher
    b>Nucleoside diphosphate kinase B (NDPKB) participates in the activation of heterotrimeric and monomeric G proteins, which are pivotal mediators in angiogenic signaling. The role of NDPKB in angiogenesis has to date not been defined...
  6. Hippe H, Wolf N, Abu Taha I, Mehringer R, Just S, Lutz S, et al. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A. 2009;106:16269-74 pubmed publisher
    ..Here, we show that the association of nucleoside diphosphate kinase B (NDPK B) with the G protein betagamma dimer (Gbetagamma) is required for G protein function in vivo...
  7. Masuda Y, Oku H, Okumura T, Nomura K, Kurokawa T. Feeding restriction alters expression of some ATP related genes more sensitively than the RNA/DNA ratio in zebrafish, Danio rerio. Comp Biochem Physiol B Biochem Mol Biol. 2009;152:287-91 pubmed publisher
    ..The ATP metabolic system is more sensitive to moderate nutrient shortages than the myogenic system. ..
  8. Cortelazzo A, Pietri T, De Felice C, Leoncini S, Guerranti R, Signorini C, et al. Proteomic analysis of the Rett syndrome experimental model mecp2Q63X mutant zebrafish. J Proteomics. 2017;154:128-133 pubmed publisher
    ..This non-mammalian vertebrate model of RTT strongly suggests a broad impact of Mecp2 dysfunction. ..
  9. Desvignes T, Pontarotti P, Fauvel C, Bobe J. Nme protein family evolutionary history, a vertebrate perspective. BMC Evol Biol. 2009;9:256 pubmed publisher
    ..Based on protein structure and expression data, we also provide new insight into molecular functions of Nme proteins among vertebrates and raise intriguing questions on the roles of Nme proteins in gonads. ..

More Information


  1. Desvignes T, Fauvel C, Bobe J. The NME gene family in zebrafish oogenesis and early development. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:439-49 pubmed publisher
    ..After zygotic genome activation, we observed an increased expression of nme2b1, nme2b2, nme3, and nme6...
  2. Zhao S, Xie P, Li G, Jun C, Cai Y, Xiong Q, et al. The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Proteomics. 2012;12:300-12 pubmed publisher
    ..In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress. ..
  3. Gündel U, Kalkhof S, Zitzkat D, von Bergen M, Altenburger R, Küster E. Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome. Ecotoxicol Environ Saf. 2012;76:11-22 pubmed publisher
    ..Using this experimental design based on testing of several exposure concentrations and less replicates might provide a step forward in getting increased output from toxicoproteomics studies. ..
  4. Chen K, Cole R, Rees B. Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. J Proteomics. 2013;78:477-85 pubmed publisher
    ..These proteomic changes may contribute to the acclimation of zebrafish to hypoxia, thereby increasing their tolerance of low oxygen concentrations. ..