nma

Summary

Gene Symbol: nma
Description: BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a
Alias: Zfnma, bambi, cb998, fc44c12, id:ibd5020, nma, wu:fc44c12, wu:fe01e03, BMP and activin membrane-bound inhibitor homolog, etID64300.12
Species: zebrafish

Top Publications

  1. Schebesta M, Lien C, Engel F, Keating M. Transcriptional profiling of caudal fin regeneration in zebrafish. ScientificWorldJournal. 2006;6 Suppl 1:38-54 pubmed
    ..as differentially expressed during regeneration, and (3) in situ hybridization of the up-regulated genes bambi, dlx5A, and her6...
  2. O Connor M, Salles I, Cvejic A, Watkins N, Walker A, Garner S, et al. Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood. 2009;113:4754-62 pubmed publisher
    ..We identified a putative role for BAMBI and LRRC32 in promotion and DCBLD2 and ESAM in inhibition of thrombus formation...
  3. Sarras M, Leontovich A, Olsen A, Intine R. Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish. Wound Repair Regen. 2013;21:320-8 pubmed publisher
    ..The aberrant expression of key regulatory genes in the DM state that persist into the MM state provides a plausible explanation on how hyperglycemia induced impaired fin regeneration in the adult zebrafish DM/MM model. ..
  4. Leichsenring M, Maes J, Mössner R, Driever W, Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013;341:1005-9 pubmed publisher
    ..Our data position Pou5f1 and SOX-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control. ..
  5. Nicoli S, Gilardelli C, Pozzoli O, Presta M, Cotelli F. Regulated expression pattern of gremlin during zebrafish development. Gene Expr Patterns. 2005;5:539-44 pubmed
    ..Finally, grm transcript is strongly downregulated in fibroblast growth factor-8 (fgf8) and sonic hedgehog (shh) mutants, thus implicating a putative role of Fgf/Shh signalling loop in grm expression regulation. ..
  6. Haycraft C, Serra R. Cilia involvement in patterning and maintenance of the skeleton. Curr Top Dev Biol. 2008;85:303-32 pubmed publisher
    ..In this article we describe what is currently known about the localization of cilia in the skeleton as well as the roles and underlying molecular mechanisms of cilia in skeletal development. ..
  7. Aamar E, Dawid I. Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish. Dev Dyn. 2010;239:2980-8 pubmed publisher
    ..These defects correlated with the formation of small KVs with apparently diminished cilia, consistent with the known requirement for ciliary function in the laterality organ for the establishment of L-R asymmetry. ..
  8. Holly V, Widen S, Famulski J, Waskiewicz A. Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development. Dev Biol. 2014;388:192-204 pubmed publisher
    ..Overexpression of a low dose of sfrp5 mRNA causes an increase in dorsal retina marker gene expression. We propose a model in which Sfrp proteins function as facilitators of both BMP and Wnt signaling within the dorsal retina. ..
  9. Heermann S, Schütz L, Lemke S, Krieglstein K, Wittbrodt J. Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein. elife. 2015;4: pubmed publisher
    ..BMP-mediated inhibition of the flow results in ectopic neuroretina in the RPE domain. Ultimately the ventral fissure fails to close resulting in coloboma. ..

More Information

Publications14

  1. Zhou F, Xie F, Jin K, Zhang Z, Clerici M, Gao R, et al. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO J. 2017;36:1623-1639 pubmed publisher
    ..Moreover, zebrafish depleted of USP4 exhibited defective cell migration and slower coordinated cell movement known as epiboly, both of which could be rescued by SMAD4. Therefore, USP4 is a critical determinant of SMAD4 activity. ..
  2. Tsang M, Kim R, de Caestecker M, Kudoh T, Roberts A, Dawid I. Zebrafish nma is involved in TGFbeta family signaling. Genesis. 2000;28:47-57 pubmed
    ..isolated the zebrafish gene, nma, that encodes a protein with high sequence similarity to human NMA and Xenopus Bambi. It is also similar to TGFbeta type I serine/theronine kinase receptors in the extracellular ligand-binding domain ..
  3. French C, Erickson T, French D, Pilgrim D, Waskiewicz A. Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development. Dev Biol. 2009;333:37-47 pubmed publisher
    ..Taken together, these data indicate that Gdf6a initiates dorsal retinal patterning independent of Bmp4, and regulates lens differentiation. ..
  4. Page L, Polok B, Bustamante M, Schorderet D. Bigh3 is upregulated in regenerating zebrafish fin. Zebrafish. 2013;10:36-42 pubmed publisher
    ..We show that upregulation of bigh3 and bambia mRNA correlated with the process of fin regeneration and regulation of TGF-b signaling, suggesting a new role for these proteins. ..
  5. Nguyen T, Tran V, Sorna V, Eriksson I, Kojima A, Koketsu M, et al. Dimerized glycosaminoglycan chains increase FGF signaling during zebrafish development. ACS Chem Biol. 2013;8:939-48 pubmed publisher
    ..On the basis of these in vivo findings, we propose a new model for GAG/FGF/FGFR interactions in which dimerized GAG chains can activate FGF-mediated signal transduction pathways. ..