nkx2.9

Summary

Gene Symbol: nkx2.9
Description: NK2 transcription factor related, locus 9 (Drosophila)
Alias: fc92g07, wu:fc92g07, wu:fk49f03, homeobox protein Nkx-2.8, homeobox transcription factor
Species: zebrafish

Top Publications

  1. Guner B, Karlstrom R. Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube. Gene Expr Patterns. 2007;7:596-605 pubmed
  2. Yang L, Rastegar S, Strahle U. Regulatory interactions specifying Kolmer-Agduhr interneurons. Development. 2010;137:2713-22 pubmed publisher
    ..show here that the differentiation of the correct number of KA' cells depends on the activity of the homeobox transcription factor Nkx2.9. This factor acts in concert with Nkx2.2a and Nkx2.2b...
  3. Guner B, Ozacar A, Thomas J, Karlstrom R. Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis. Endocrinology. 2008;149:4435-51 pubmed publisher
    ..These data suggest that there are distinct origins and signaling requirements for the PD and PI. ..
  4. Zheng D, Kille P, Feeney G, Cunningham P, Handy R, Hogstrand C. Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. BMC Genomics. 2010;11:553 pubmed publisher
    ..This organ forms a conduit for zinc uptake whilst exhibiting conservation of zinc trafficking components...
  5. Büttner A, Busch W, Klüver N, Giannis A, Scholz S. Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine. Reprod Toxicol. 2012;33:254-63 pubmed publisher
    ..Reasons for the discrepancies between cellular reporter and the zebrafish embryo assay and potential implications for the identification of compounds interfering with specific developmental pathways are discussed. ..
  6. Huang P, Xiong F, Megason S, Schier A. Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genet. 2012;8:e1002762 pubmed publisher
  7. Yu X, Ng C, Habacher H, Roy S. Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat Genet. 2008;40:1445-53 pubmed publisher
    ..Our findings identify a dedicated master regulatory role for Foxj1 in the transcriptional program that controls the production of motile cilia. ..
  8. Bergeron S, Tyurina O, Miller E, Bagas A, Karlstrom R. Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Development. 2011;138:75-85 pubmed publisher
    ..This study reveals a role for Boc in ventral CNS cells that receive high levels of Hh and uncovers previously unknown roles for Boc in vertebrate embryogenesis. ..
  9. Al Oustah A, Danesin C, Khouri Farah N, Farreny M, Escalas N, Cochard P, et al. Dynamics of sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring sulfatase 1. Development. 2014;141:1392-403 pubmed publisher
    ..Our work, by pointing out the key role of Sulf1 in regulating Shh-dependent neural cell diversity, highlights a novel level of regulation, which involves temporal evolution of Shh source properties. ..

More Information

Publications10

  1. Arnold C, Lamont R, Walker J, Spice P, Chan C, Ho C, et al. Comparative analysis of genes regulated by Dzip1/iguana and hedgehog in zebrafish. Dev Dyn. 2015;244:211-23 pubmed publisher
    ..Through comparing gene expression changes in a genetic model of vascular instability with a chemical inhibition of Hh signaling, we identified a set of 40 differentially expressed genes with potential roles in vascular stabilization. ..