nkx2.1a

Summary

Gene Symbol: nkx2.1a
Description: NK2 homeobox 1a
Alias: nk2.1a, nkx2.1, nkx2.4a, titf1, titf1a, thyroid transcription factor 1a
Species: zebrafish

Top Publications

  1. ncbi Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors
    Osama A Elsalini
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Koln, Germany
    Dev Biol 263:67-80. 2003
  2. doi Ontogeny of vasotocin-expressing cells in zebrafish: selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area
    Jennifer L Eaton
    Department of Biology, The University of Akron, Akron, Ohio, USA
    Dev Dyn 237:995-1005. 2008
  3. ncbi Genetic analysis of adenohypophysis formation in zebrafish
    Wiebke Herzog
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Mol Endocrinol 18:1185-95. 2004
  4. ncbi Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution
    Kristin Tessmar-Raible
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
    Cell 129:1389-400. 2007
  5. ncbi The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity
    K B Rohr
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 29:341-51. 2001
  6. doi Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1
    Catherine Danesin
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, UK
    Dev Cell 16:576-87. 2009
  7. doi Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish
    Gayathri Chandrasekar
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Neurotoxicol Teratol 33:752-64. 2011
  8. doi Zebrafish Dmrta2 regulates neurogenesis in the telencephalon
    Akio Yoshizawa
    Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama 1 3 1, Higashi Hiroshima, Hiroshima 739 8526 Japan
    Genes Cells 16:1097-109. 2011
  9. doi Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish
    Liqin Yu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Environ Sci Technol 45:10652-9. 2011
  10. doi Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae
    Qi Chen
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Aquat Toxicol 110:141-8. 2012

Scientific Experts

  • Kristin Tessmar-Raible
  • Deborah M Kurrasch
  • Liqin Yu
  • Jennifer L Eaton
  • Robert Opitz
  • Osama A Elsalini
  • Klaus B Rohr
  • Wiebke Herzog
  • Burkhard Alt
  • Bingsheng Zhou
  • Soojin Ryu
  • Eric Glasgow
  • Thomas Wendl
  • Corinne Houart
  • Viktoria Schiller
  • Andrea Wolf
  • Gilbert Lauter
  • Adriana Bosco
  • Qi Chen
  • Immacolata Porreca
  • Idoia Quintana-Urzainqui
  • Matthias Hammerschmidt
  • Patrizia Porazzi
  • Crystal Y Usenko
  • Sabine Costagliola
  • Emilie Maquet
  • Donghun Shin
  • Akio Yoshizawa
  • Gayathri Chandrasekar
  • Michele Rouleau
  • Laure Bally-Cuif
  • Xi Li
  • Catherine Danesin
  • Chisako Nakada
  • Masatake Kai
  • Patricia A Gongal
  • Kar Lai Poon
  • Catherine W McCollum
  • Jae Yeon Jeong
  • Ji Eun Lee
  • Christian Stigloher
  • Hans Martin Pogoda
  • K B Rohr
  • Sophia von der Hardt
  • S W Wilson
  • Matthias Schafer
  • K A Barth
  • Benjamin M Hogan
  • Marika Kapsimali
  • Carmen Sonntag
  • Stephen W Wilson
  • Juliette Mathieu
  • Martina Fenske
  • Patricia Gaspar
  • Arne Wichmann
  • Iris Söll
  • Charlotte Bureau
  • Giselbert Hauptmann
  • Markus Hecker
  • John P Giesy
  • Pierre Affaticati
  • Elke Muth-Köhne
  • Ralf Kriehuber
  • Christina Lillesaar
  • Elena De Felice
  • Gabriel Santos-Durán
  • Tiziana de Filippis
  • Francesco Argenton
  • Stephen J Trumble
  • Eva Candal
  • Isabel Rodríguez-Moldes
  • Achim Trubiroha
  • Erica D Bruce
  • Francesca Benato
  • Catalina Sueiro
  • Jan Huisken
  • Lihua Yang
  • Gaelle Pottier
  • Ivan Carrera
  • Davide Calebiro
  • Francesco Antonica
  • Natascia Tiso
  • Roberto Di Lauro
  • Susana Ferreiro-Galve
  • Sylvie Mazan
  • Federica Marelli
  • David C Hopkins
  • Henrik Fagman
  • Véronique Janssens
  • Sol Pose-Méndez

Detail Information

Publications48

  1. ncbi Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors
    Osama A Elsalini
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Koln, Germany
    Dev Biol 263:67-80. 2003
    ..Our functional analysis suggests that these genes have similar roles as in mammalian thyroid development, albeit in a different temporal mode of organogenesis...
  2. doi Ontogeny of vasotocin-expressing cells in zebrafish: selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area
    Jennifer L Eaton
    Department of Biology, The University of Akron, Akron, Ohio, USA
    Dev Dyn 237:995-1005. 2008
    ..In contrast, otp and sim1 are not required for avt expression in the ventral hypothalamus. Thus, the development of these two avt expression domains is influenced by separate gene regulatory networks...
  3. ncbi Genetic analysis of adenohypophysis formation in zebrafish
    Wiebke Herzog
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Mol Endocrinol 18:1185-95. 2004
    ..Positional cloning of the lia, pia, and aal genes might reveal novel regulators of vertebrate pituitary development...
  4. ncbi Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution
    Kristin Tessmar-Raible
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
    Cell 129:1389-400. 2007
    ....
  5. ncbi The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity
    K B Rohr
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 29:341-51. 2001
    ..Thus, the Nodal pathway regulates ventral forebrain patterning through both Hedgehog signaling-dependent and -independent mechanisms...
  6. doi Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1
    Catherine Danesin
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, UK
    Dev Cell 16:576-87. 2009
    ..Altogether, these findings identify a key direct target of Foxg1, and uncover a simple molecular mechanism by which Foxg1 integrates two opposing signaling centers...
  7. doi Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish
    Gayathri Chandrasekar
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Neurotoxicol Teratol 33:752-64. 2011
    ..These data suggest that 4-NP enduringly affects the embryonic development in zebrafish and that this compound might exert these deleterious effects through diverse signaling pathways...
  8. doi Zebrafish Dmrta2 regulates neurogenesis in the telencephalon
    Akio Yoshizawa
    Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama 1 3 1, Higashi Hiroshima, Hiroshima 739 8526 Japan
    Genes Cells 16:1097-109. 2011
    ..These results suggest that Dmrta2 plays important roles in the specification of the posterior-dorsal telencephalic cell fate during somitogenesis...
  9. doi Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish
    Liqin Yu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Environ Sci Technol 45:10652-9. 2011
    ..For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations...
  10. doi Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae
    Qi Chen
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Aquat Toxicol 110:141-8. 2012
    ..These results suggest that the hypothalamic-pituitary-thyroid axis can be evaluated to determine thyroid endocrine disruption by BDE-209 in developing zebrafish larvae...
  11. doi Zebrafish bcl2l is a survival factor in thyroid development
    Immacolata Porreca
    IRGS, BIOGEM, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy
    Dev Biol 366:142-52. 2012
    ..This is the first demonstration of an active mechanism to ensure survival of the thyroid primordium during morphogenesis...
  12. doi Hydroxylated PBDEs induce developmental arrest in zebrafish
    Crystal Y Usenko
    Baylor University, Waco, TX, USA
    Toxicol Appl Pharmacol 262:43-51. 2012
    ..This study suggests that hydroxylated PBDEs disrupt development, and may induce oxidative stress and potentially disrupt the cholinergic system and thyroid hormone homeostasis...
  13. doi Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2
    Andrea Wolf
    Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research, Heidelberg, Germany
    Development 140:1762-73. 2013
    ....
  14. doi Contributions of developmental studies in the dogfish Scyliorhinus canicula to the brain anatomy of elasmobranchs: insights on the basal ganglia
    Idoia Quintana-Urzainqui
    Department of Cell Biology and Ecology, CIBUS, University of Santiago de Compostela, Spain
    Brain Behav Evol 80:127-41. 2012
    ..Our observations may shed light on postulate equivalences of regions and nuclei among elasmobranchs and support homologies with other vertebrates...
  15. doi Disruptions of global and JAGGED1-mediated notch signaling affect thyroid morphogenesis in the zebrafish
    Patrizia Porazzi
    Dipartimento di Scienze Cliniche e di Comunità, Universita degli Studi di Milano, Milan, Italy
    Endocrinology 153:5645-58. 2012
    ..Thus, genetic alterations affecting the Notch pathway may confer susceptibility for thyroid dysgenesis...
  16. doi Studying the effects of genistein on gene expression of fish embryos as an alternative testing approach for endocrine disruption
    Viktoria Schiller
    Fraunhofer Institute for Molecular Biology and Applied Ecology, Aachen, Germany
    Comp Biochem Physiol C Toxicol Pharmacol 157:41-53. 2013
    ....
  17. doi Molecular characterization of prosomeric and intraprosomeric subdivisions of the embryonic zebrafish diencephalon
    Gilbert Lauter
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    J Comp Neurol 521:1093-118. 2013
    ..Our comparative gene expression analysis conformed with the idea of a common bauplan for the diencephalon of anamniote and amniote vertebrates from fish to mammals...
  18. doi Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b
    Adriana Bosco
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, CNRS UPR3294, Institute of Neurobiology Albert Fessard, 1 Avenue de Terrasse, 91198 Gif sur Yvette, France
    Development 140:372-84. 2013
    ..Our results highlight a novel role for Etv5b in neuronal development and provide support for the existence of a developmental heterogeneity among 5-HT neurons in their requirement for ETS-domain transcription factors...
  19. doi Transgenic zebrafish illuminate the dynamics of thyroid morphogenesis and its relationship to cardiovascular development
    Robert Opitz
    Institute of Interdisciplinary Research in Molecular Human Biology IRIBHM, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Dev Biol 372:203-16. 2012
    ....
  20. doi Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish
    Chisako Nakada
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    J Exp Zool B Mol Dev Evol 312:827-40. 2009
    ..Furthermore, the roles reported for FOXE1 in mammalian thyroid development may have been acquired during evolution...
  21. ncbi Bmp activity establishes a gradient of positional information throughout the entire neural plate
    K A Barth
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 126:4977-87. 1999
    ..These results are consistent with there being a gradient of Bmp-dependent positional information extending throughout the entire neural and non-neural ectoderm...
  22. pmc Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish
    Deborah M Kurrasch
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
    Neural Dev 4:22. 2009
    ..The conserved function and spatial expression of hypothalamic peptides in vertebrates prompted us to search for critical neuroendocrine genes in newly hatched zebrafish larvae...
  23. doi Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae
    Liqin Yu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China
    Aquat Toxicol 97:226-33. 2010
    ....
  24. pmc A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development
    Michele Rouleau
    Cancer Research Laboratory, CHUQ Research Center, Centre hospitalier de l Universite Laval, Quebec, Canada
    PLoS ONE 6:e15834. 2011
    ..In contrast to PARP1 and PARP2, the functions of PARP3 are undefined. Here, we reveal critical functions for PARP3 during vertebrate development...
  25. pmc Restriction of hepatic competence by Fgf signaling
    Donghun Shin
    Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:1339-48. 2011
    ..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
  26. doi TSH receptor function is required for normal thyroid differentiation in zebrafish
    Robert Opitz
    Institute of Interdisciplinary Research in Molecular Human Biology, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Endocrinol 25:1579-99. 2011
    ..A comparison of our results with phenotypes observed in mouse models of defective TSHR and cAMP signaling highlights the value of zebrafish as a model to enhance the understanding of functional differentiation in the vertebrate thyroid...
  27. doi The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development
    Xi Li
    Key Laboratory of Biodiversity and Conservation of Aquatic Organisms, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, People s Republic of China
    Endocrinology 150:2767-74. 2009
    ..Our research here has demonstrated that zebrafish is a unique model for functional studies of endogenous ghrelin, especially during embryonic development...
  28. doi Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation
    Masatake Kai
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Development 135:3043-51. 2008
    ..These results suggest that the net migration of prechordal plate progenitors is determined by different parameters, including motility, persistence and coherence...
  29. ncbi Analysis of origin and growth of the thyroid gland in zebrafish
    Burkhard Alt
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Koln, Germany
    Dev Dyn 235:1872-83. 2006
    ..Mosaic analysis suggests that the first thyroid follicle differentiating at 55 hours postfertilization corresponds later to the most anterior follicle and that new follicles are added caudally...
  30. ncbi The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis
    Hans Martin Pogoda
    Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Development 133:1079-89. 2006
    ..Together, this suggests that Ascl1a might act downstream of diencephalic Fgf3 signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis...
  31. ncbi Hedgehog and retinoid signalling confines nkx2.2b expression to the lateral floor plate of the zebrafish trunk
    Matthias Schafer
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Mech Dev 122:43-56. 2005
    ..g. tal2 or foxa2, nkx2.2b is exclusively expressed in the LFP. Thus, it represents a unique tool to analyse the mechanisms of ventral neural tube patterning in zebrafish...
  32. ncbi Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Dev Biol 276:508-22. 2004
    ..This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies...
  33. pmc Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity
    Marika Kapsimali
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:5923-33. 2004
    ....
  34. ncbi Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis
    Wiebke Herzog
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 131:3681-92. 2004
    ..This early specification seems to be essential for the subsequent survival of pituitary cells, but not for pituitary morphogenesis or pituitary cell proliferation...
  35. ncbi Phenylthiourea disrupts thyroid function in developing zebrafish
    Osama A Elsalini
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Cologne, Germany
    Dev Genes Evol 212:593-8. 2003
    ..At doses of 0.003% PTurea, however, toxic side effects seem to be at a minimum, and the maternal contribution of the hormone might compensate for compromised thyroid function during the first days of development...
  36. ncbi Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development
    Juliette Mathieu
    U 368 INSERM, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Development 129:3055-65. 2002
    ..Finally we show that it is the prechordal plate and not the head endoderm that provides the early signals essential for establishment of the hypothalamus...
  37. ncbi The zebrafish bHLH PAS transcriptional regulator, single-minded 1 (sim1), is required for isotocin cell development
    Jennifer L Eaton
    Graduate Program in Cellular and Molecular Biology, School of Biomedical Sciences, Kent State University, Kent, Ohio, USA
    Dev Dyn 235:2071-82. 2006
    ..We provide evidence that the role of sim1 in zebrafish neuroendocrine cell development is evolutionarily conserved with that of mammals...
  38. ncbi Segregation of telencephalic and eye-field identities inside the zebrafish forebrain territory is controlled by Rx3
    Christian Stigloher
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675, Munich, Germany
    Development 133:2925-35. 2006
    ..These results suggest that the process segregating the telencephalic and eye fields is isolated from diencephalic patterning, and is mediated by Rx3...
  39. ncbi Arteries define the position of the thyroid gland during its developmental relocalisation
    Burkhard Alt
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, Koln, Germany
    Development 133:3797-804. 2006
    ..Moreover, the involvement of vessels in thyroid relocalisation sheds new light on the interpretation of congenital thyroid defects in humans...
  40. doi Expression of zebrafish nos2b surrounds oral cavity
    Kar Lai Poon
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Dev Dyn 237:1662-7. 2008
    ..Thus, the analysis of expression pattern of nos2b reveals complex morphogenetic movements resulting in its expression surrounding the oral cavity...
  41. ncbi Zebrafish orthopedia (otp) is required for isotocin cell development
    Jennifer L Eaton
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, 232 Building D, 4000 Reservoir Rd, NW Washington, DC 20057, USA
    Dev Genes Evol 217:149-58. 2007
    ..Overall, these studies support the hypothesis that the role of otp in zebrafish neuroendocrine cell development is evolutionarily conserved with that of mammals...
  42. ncbi Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism
    Patricia A Gongal
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Hum Mol Genet 17:525-38. 2008
    ..The consequences of abnormal RA levels for forebrain patterning are profound, and imply that in human patients with TGIF deficiencies, increased forebrain RA levels contribute to the development of HPE...
  43. pmc A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3
    Catherine W McCollum
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA
    Dev Biol 309:373-85. 2007
    ..We propose that lmo4b has an essential role in forebrain development as a modulator of six3 and rx3 expression, and thus indirectly influences neural cell fate commitment, cell proliferation and tissue growth in the anterior CNS...
  44. ncbi Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals
    Thomas Wendl
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Koln, Germany
    Development 134:2871-9. 2007
    ..FGF-soaked beads can restore thyroid development in han mutants, showing that FGFs act downstream of or in parallel to han. These data suggest that loss of FGF-expressing tissue in han mutants is responsible for the thyroid defects...
  45. ncbi Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development
    Soojin Ryu
    Department of Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    Curr Biol 17:873-80. 2007
    ..Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system...
  46. ncbi Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl
    Jae Yeon Jeong
    Program in Developmental Biology, Department of Biopharmaceutical Sciences, University of California San Francisco, CA 94143 2811, USA
    Development 134:127-36. 2007
    ..Our findings reveal that Fezl is crucial for establishing regional subdivisions within the diencephalon and may also play a role in the development of the telencephalon and hypothalamus...
  47. ncbi Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis
    Ji Eun Lee
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84105, USA
    Development 133:4451-61. 2006
    ..The conserved presence of this pathway in other vertebrates suggests a common mechanism for regulating hypothalamic neurogenesis...
  48. ncbi Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon
    S Shanmugalingam
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 127:2549-61. 2000
    ..However, as ace mutant neural plate cells still retain at least some inductive activity, then other signals must also be produced by the anterior margin of the neural plate...