ngb

Summary

Gene Symbol: ngb
Description: neuroglobin
Alias: neuroglobin
Species: zebrafish

Top Publications

  1. Awenius C, Hankeln T, Burmester T. Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis. Biochem Biophys Res Commun. 2001;287:418-21 pubmed
    b>Neuroglobin is a recently discovered respiratory, porphyrin-containing protein that is expressed in the brain of mouse and man. Here we show that neuroglobin is also present in the teleost fish...
  2. Fuchs C, Heib V, Kiger L, Haberkamp M, Roesner A, Schmidt M, et al. Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern, and ligand binding. J Biol Chem. 2004;279:24116-22 pubmed
    b>Neuroglobin has been identified as a respiratory protein that is primarily expressed in the mammalian nervous system. Here we present the first detailed analysis of neuroglobin from a non-mammalian vertebrate, the zebrafish Danio rerio...
  3. Watanabe S, Wakasugi K. Identification of residues critical for the cell-membrane-penetrating activity of zebrafish neuroglobin. FEBS Lett. 2010;584:2467-72 pubmed publisher
    b>Neuroglobin (Ngb) is a globin found in the vertebrate brain. Recently, we found that zebrafish Ngb can translocate into cells and clarified that module M1 of zebrafish Ngb is important for protein transduction...
  4. Watanabe S, Wakasugi K. Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity. Biochem Biophys Res Commun. 2008;369:695-700 pubmed publisher
    Mammalian neuroglobin (Ngb) is involved in neuroprotection under oxidative stress conditions such as ischemia and reperfusion. However, the neuroprotective mechanism remains unclear...
  5. Wakasugi K, Morishima I. Identification of residues in human neuroglobin crucial for Guanine nucleotide dissociation inhibitor activity. Biochemistry. 2005;44:2943-8 pubmed
    b>Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen...
  6. Wakasugi K, Morishima I. Preparation and characterization of a chimeric zebrafish-human neuroglobin engineered by module substitution. Biochem Biophys Res Commun. 2005;330:591-7 pubmed
    b>Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that can reversibly bind oxygen that is expressed in the brain. Zebrafish and human Ngb share about 50% amino acid sequence identity...
  7. Watanabe S, Wakasugi K. Zebrafish neuroglobin is a cell-membrane-penetrating globin. Biochemistry. 2008;47:5266-70 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen...
  8. Kamioka Y, Fujikawa C, Ogai K, Sugitani K, Watanabe S, Kato S, et al. Functional characterization of fish neuroglobin: zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells. Biochim Biophys Acta. 2013;1834:1779-88 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen...
  9. Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
    ..Here we investigate by means of quantitative real-time PCR the changes of hemoglobin, myoglobin, neuroglobin, cytoglobin and globin X mRNA in zebrafish (Danio rerio) exposed to mild (PO2=approximately 8...

More Information

Publications19

  1. Roesner A, Mitz S, Hankeln T, Burmester T. Globins and hypoxia adaptation in the goldfish, Carassius auratus. FEBS J. 2008;275:3633-43 pubmed publisher
    ..the complete coding sequence of hemoglobin alpha and beta and myoglobin, as well as partial cDNAs from neuroglobin and cytoglobin. Like the common carp (Cyprinus carpio), C...
  2. Watanabe S, Wakasugi K. Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity. PLoS ONE. 2011;6:e16808 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered vertebrate globin that is expressed in the brain and can reversibly bind oxygen...
  3. Blank M, Burmester T. Widespread occurrence of N-terminal acylation in animal globins and possible origin of respiratory globins from a membrane-bound ancestor. Mol Biol Evol. 2012;29:3553-61 pubmed publisher
  4. Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
    ..These findings agree with the role of globins in oxidative energy metabolism, but may also hint at a specific function in antioxidative defense. ..
  5. Hundahl C, Fago A, Dewilde S, Moens L, Hankeln T, Burmester T, et al. Oxygen binding properties of non-mammalian nerve globins. FEBS J. 2006;273:1323-9 pubmed
    ..an annelid (Aphrodite aculeata), a nemertean (Cerebratulus lacteus) and a bivalve (Spisula solidissima) and of neuroglobin from zebrafish (Danio rerio)...
  6. Tiedke J, Gerlach F, Mitz S, Hankeln T, Burmester T. Ontogeny of globin expression in zebrafish (Danio rerio). J Comp Physiol B. 2011;181:1011-21 pubmed publisher
    ..mRNA levels of the hemoglobin chains, including a newly identified embryonic ?-chain, as well as myoglobin, neuroglobin, cytoglobin 1 and 2, and globin X were estimated...
  7. Sugitani K, Koriyama Y, Ogai K, Wakasugi K, Kato S. A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina. Adv Exp Med Biol. 2016;854:671-5 pubmed publisher
    b>Neuroglobin (Ngb) is a new member of the family of heme proteins and is specifically expressed in neurons of the central and peripheral nervous systems in all vertebrates...
  8. Corti P, Ieraci M, Tejero J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric Oxide. 2016;53:22-34 pubmed publisher
    b>Neuroglobin (Ngb) and cytoglobin (Cygb) are two six-coordinate heme proteins of unknown physiological function...
  9. Takahashi N, Onozuka W, Watanabe S, Wakasugi K. Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth. FEBS Open Bio. 2017;7:1338-1349 pubmed publisher
    b>Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain...
  10. Sugitani K, Koriyama Y, Sera M, Arai K, Ogai K, Wakasugi K. A novel function of neuroglobin for neuroregeneration in mice after optic nerve injury. Biochem Biophys Res Commun. 2017;493:1254-1259 pubmed publisher
    b>Neuroglobin (Ngb) is a recently discovered heme protein in the vertebrate brain that can bind to oxygen molecules. Mammalian Ngb plays a crucial role in neuroprotection under conditions of oxidative stress...