nfkbiab

Summary

Gene Symbol: nfkbiab
Description: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b
Alias: NFKBIA, ikbaB, wu:fb81f08, zgc:56666, zgc:77616, NF-kappa-B inhibitor alpha, NF-kappaB inhibitor alpha-like protein B
Species: zebrafish

Top Publications

  1. Kanther M, Sun X, Muhlbauer M, Mackey L, Flynn E, Bagnat M, et al. Microbial colonization induces dynamic temporal and spatial patterns of NF-?B activation in the zebrafish digestive tract. Gastroenterology. 2011;141:197-207 pubmed publisher
    ..The observed patterns of NF-?B-dependent responses to microbial colonization indicate that cells in the gastrointestinal tract respond robustly to the microbial environment. ..
  2. Gao R, Huang Y, Huang X, Guan L, Wei S, Zhou Y, et al. Molecular cloning and characterization of two types of I?B? orthologues in orange-spotted grouper, Epinephelus coioides. Fish Shellfish Immunol. 2014;38:101-10 pubmed publisher
    ..Taken together, our findings suggested that both EcI?B?A and EcI?B?B were involved in grouper innate immunity against virus. ..
  3. Correa R, Tergaonkar V, Ng J, Dubova I, Izpisua Belmonte J, Verma I. Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. Mol Cell Biol. 2004;24:5257-68 pubmed
    ..Our study illustrates the conservation and compatibility of NF-kappa B/I kappa B proteins among vertebrates and the importance of NF-kappa B pathway in mesoderm formation during early embryogenesis. ..
  4. Kovács R, Csenki Z, Bakos K, Urbányi B, Horváth Ã, Garaj Vrhovac V, et al. Assessment of toxicity and genotoxicity of low doses of 5-fluorouracil in zebrafish (Danio rerio) two-generation study. Water Res. 2015;77:201-212 pubmed publisher
  5. Karra R, Knecht A, Kikuchi K, Poss K. Myocardial NF-κB activation is essential for zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2015;112:13255-60 pubmed publisher
    ..Our results implicate NF-κB signaling as a key node between cardiac injury and tissue regeneration. ..
  6. Zheng J, Yuan S, Wu C, Lv Z. Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio). Aquat Toxicol. 2016;180:36-44 pubmed publisher
  7. Zheng J, Yuan S, Wu C, Lv Z, Zhu A. Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish. Aquat Toxicol. 2017;182:113-119 pubmed publisher
    ..Taken together, oxidative stress and immunotoxicity in the brain were more serious when fish were exposed to Cd in the evening than in the morning, highlighting the importance of circadian rhythm in Cd-induced neurotoxicity in fish. ..
  8. Kuri P, Ellwanger K, Kufer T, Leptin M, Bajoghli B. A high-sensitivity bi-directional reporter to monitor NF-?B activity in cell culture and zebrafish in real time. J Cell Sci. 2017;130:648-657 pubmed publisher
  9. Guo S, Zheng J, Yuan S, Zhu Q, Wu C. Immunosuppressive effects and associated compensatory responses in zebrafish after full life-cycle exposure to environmentally relevant concentrations of cadmium. Aquat Toxicol. 2017;188:64-71 pubmed publisher
    ..Taken together, immunosuppressive effects and tissue-dependent compensatory responses were demonstrated in zebrafish after full life-cycle exposure to environmental levels of Cd, indicating a compromise between survival and immunity. ..

More Information

Publications16

  1. Correa R, Matsui T, Tergaonkar V, Rodriguez Esteban C, Izpisua Belmonte J, Verma I. Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity. Curr Biol. 2005;15:1291-5 pubmed
    ..Here, we report that Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB. ..
  2. Watzke J, Schirmer K, Scholz S. Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio). Fish Shellfish Immunol. 2007;23:901-5 pubmed
    ..The gene induction required the removal of the chorion prior to lipopolysaccharide exposure. ..
  3. Encinas P, Garcia Valtanen P, Chinchilla B, Gomez Casado E, Estepa A, Coll J. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. PLoS ONE. 2013;8:e73553 pubmed publisher
    ..These results could contribute to develop novel drug-based prevention methods and consolidate the zebrafish/SVCV as a model for vertebrate viral diseases. ..
  4. Hiolski E, Kendrick P, Frame E, Myers M, Bammler T, Beyer R, et al. Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquat Toxicol. 2014;155:151-9 pubmed publisher
  5. Dai Z, Wang H, Jin X, Wang H, He J, Liu M, et al. Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. Am J Physiol Endocrinol Metab. 2015;308:E849-59 pubmed publisher
  6. Hidasi A, Groh K, Suter M, Schirmer K. Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations. Ecotoxicol Environ Saf. 2017;138:16-24 pubmed publisher
    ..This may reduce the chances of fish to survive in the environment, as their defense against pathogens is weakened. ..
  7. Rauwerda H, Pagano J, de Leeuw W, Ensink W, Nehrdich U, de Jong M, et al. Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos. BMC Genomics. 2017;18:287 pubmed publisher