nfkbiaa

Summary

Gene Symbol: nfkbiaa
Description: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
Alias: ikbaA, wu:fj16a07, zgc:85769, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a, NF-kappaB inhibitor alpha-like protein A, fj16a07
Species: zebrafish

Top Publications

  1. Correa R, Matsui T, Tergaonkar V, Rodriguez Esteban C, Izpisua Belmonte J, Verma I. Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity. Curr Biol. 2005;15:1291-5 pubmed
    ..Here, we report that Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB. ..
  2. Guo S, Zheng J, Yuan S, Zhu Q, Wu C. Immunosuppressive effects and associated compensatory responses in zebrafish after full life-cycle exposure to environmentally relevant concentrations of cadmium. Aquat Toxicol. 2017;188:64-71 pubmed publisher
    ..Taken together, immunosuppressive effects and tissue-dependent compensatory responses were demonstrated in zebrafish after full life-cycle exposure to environmental levels of Cd, indicating a compromise between survival and immunity. ..
  3. He Q, Zhang C, Wang L, Zhang P, Ma D, Lv J, et al. Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 2015;125:1098-106 pubmed publisher
    ..Our findings establish a previously unrecognized link between inflammatory signaling and HSPC emergence, and provide new insights into regenerative medicine and novel therapies to treat innate immune-related diseases. ..
  4. Lu A, Hu X, Xue J, Zhu J, Wang Y, Zhou G. Gene expression profiling in the skin of zebrafish infected with Citrobacter freundii. Fish Shellfish Immunol. 2012;32:273-83 pubmed publisher
    ..This is first report that skin play important roles in innate immune responses to bacterial infection, which contribute to understanding the defense mechanisms of the skin in fish. ..
  5. Warner C, Gust K, Stanley J, Habib T, Wilbanks M, Garcia Reyero N, et al. A systems toxicology approach to elucidate the mechanisms involved in RDX species-specific sensitivity. Environ Sci Technol. 2012;46:7790-8 pubmed publisher
  6. Gao R, Huang Y, Huang X, Guan L, Wei S, Zhou Y, et al. Molecular cloning and characterization of two types of I?B? orthologues in orange-spotted grouper, Epinephelus coioides. Fish Shellfish Immunol. 2014;38:101-10 pubmed publisher
    ..Taken together, our findings suggested that both EcI?B?A and EcI?B?B were involved in grouper innate immunity against virus. ..
  7. Zhang D, Golubkov V, Han W, Correa R, Zhou Y, Lee S, et al. Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival. Dev Biol. 2014;395:96-110 pubmed publisher
    ..A role for Anxa4 in cell survival may have implications for the mechanism of diabetic ß-cell apoptosis and cancer cell chemoresistance. ..
  8. Zhang X, Zhao H, Chen Y, Luo H, Yang P, Yao B. A zebrafish (Danio rerio) bloodthirsty member 20 with E3 ubiquitin ligase activity involved in immune response against bacterial infection. Biochem Biophys Res Commun. 2015;457:83-9 pubmed publisher
    ..The results suggested that btr20 may involve in the anti-microbial activity in the immune system as an E3 ubiquitin ligase. ..
  9. Zheng J, Yuan S, Wu C, Lv Z, Zhu A. Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish. Aquat Toxicol. 2017;182:113-119 pubmed publisher
    ..Taken together, oxidative stress and immunotoxicity in the brain were more serious when fish were exposed to Cd in the evening than in the morning, highlighting the importance of circadian rhythm in Cd-induced neurotoxicity in fish. ..

More Information

Publications18

  1. Correa R, Tergaonkar V, Ng J, Dubova I, Izpisua Belmonte J, Verma I. Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. Mol Cell Biol. 2004;24:5257-68 pubmed
    ..Our study illustrates the conservation and compatibility of NF-kappa B/I kappa B proteins among vertebrates and the importance of NF-kappa B pathway in mesoderm formation during early embryogenesis. ..
  2. Ko E, Cho S, Kwon S, Eom C, Jeong M, Lee W, et al. The roles of NF-κB and ROS in regulation of pro-inflammatory mediators of inflammation induction in LPS-stimulated zebrafish embryos. Fish Shellfish Immunol. 2017;68:525-529 pubmed publisher
    ..Taken together, these results indicated that LPS increases pro-inflammatory mediators in zebrafish embryos through ROS and NF-κB regulation. ..
  3. Kanther M, Tomkovich S, Xiaolun S, Grosser M, Koo J, Flynn E, et al. Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. Cell Microbiol. 2014;16:1053-67 pubmed publisher
  4. Paulus J, Link B. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics. PLoS ONE. 2014;9:e109922 pubmed publisher
    ..Therefore, we conclude that in vivo loss of Optineurin shows some, but not all, of the defects seen in in vitro work. ..
  5. Kanther M, Sun X, Muhlbauer M, Mackey L, Flynn E, Bagnat M, et al. Microbial colonization induces dynamic temporal and spatial patterns of NF-?B activation in the zebrafish digestive tract. Gastroenterology. 2011;141:197-207 pubmed publisher
    ..The observed patterns of NF-?B-dependent responses to microbial colonization indicate that cells in the gastrointestinal tract respond robustly to the microbial environment. ..
  6. Karra R, Knecht A, Kikuchi K, Poss K. Myocardial NF-κB activation is essential for zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2015;112:13255-60 pubmed publisher
    ..Our results implicate NF-κB signaling as a key node between cardiac injury and tissue regeneration. ..
  7. Kuri P, Ellwanger K, Kufer T, Leptin M, Bajoghli B. A high-sensitivity bi-directional reporter to monitor NF-?B activity in cell culture and zebrafish in real time. J Cell Sci. 2017;130:648-657 pubmed publisher
  8. Zheng J, Yuan S, Wu C, Lv Z. Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio). Aquat Toxicol. 2016;180:36-44 pubmed publisher
  9. Hidasi A, Groh K, Suter M, Schirmer K. Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations. Ecotoxicol Environ Saf. 2017;138:16-24 pubmed publisher
    ..This may reduce the chances of fish to survive in the environment, as their defense against pathogens is weakened. ..