Gene Symbol: nfe2l2a
Description: nuclear factor, erythroid 2-like 2a
Alias: Nrf2, nfe2l2, wu:fc15g09, wu:fj67e03, nuclear factor erythroid 2-related factor 2, Nrf2a, nuclear factor (erythroid-derived 2)-like 2, nuclear factor (erythroid-derived 2)-like 2a
Species: zebrafish

Top Publications

  1. Suzuki T, Takagi Y, Osanai H, Li L, Takeuchi M, Katoh Y, et al. Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish. Biochem J. 2005;388:65-73 pubmed
    ..All the vertebrate Pi class GST genes harbour a similar ARE-like sequence in their promoter regions. We propose that this sequence is a conserved target site for Nrf 2 in the Pi class GST genes. ..
  2. Kobayashi M, Li L, Iwamoto N, Nakajima Takagi Y, Kaneko H, Nakayama Y, et al. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol. 2009;29:493-502 pubmed publisher
    ..The antioxidant transcription factor Nrf2 is activated in response to various electrophiles and induces cytoprotective enzymes that detoxify them...
  3. Timme Laragy A, Van Tiem L, Linney E, Di Giulio R. Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicol Sci. 2009;109:217-27 pubmed publisher
    ..In addition, we used a morpholino to knockdown expression of the antioxidant response element transcription factor NRF2 to determine if this would alter gene expression or increase deformity severity...
  4. Timme Laragy A, Karchner S, Franks D, Jenny M, Harbeitner R, Goldstone J, et al. Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). J Biol Chem. 2012;287:4609-27 pubmed publisher
    NF-E2-related factor 2 (NRF2; also called NFE2L2) and related NRF family members regulate antioxidant defenses by activating gene expression via antioxidant response elements (AREs), but their roles in embryonic development are not well ..
  5. Takagi Y, Kobayashi M, Li L, Suzuki T, Nishikawa K, Yamamoto M. MafT, a new member of the small Maf protein family in zebrafish. Biochem Biophys Res Commun. 2004;320:62-9 pubmed
    ..MafT protein bound MARE sequence as a homodimer or heterodimers with zebrafish Nrf2 or p45 Nfe2...
  6. Kobayashi M, Itoh K, Suzuki T, Osanai H, Nishikawa K, Katoh Y, et al. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells. 2002;7:807-20 pubmed
    The transcription factor Nrf2 and its negative regulator Keap1 play important roles in transcriptional induction of a set of detoxifying and anti-oxidant enzymes...
  7. Williams L, Timme Laragy A, Goldstone J, McArthur A, Stegeman J, Smolowitz R, et al. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS ONE. 2013;8:e79574 pubmed publisher
    ..We explored the expression and function of six nrf genes (nfe2, nrf1a, nrf1b, nrf2a, nrf2b, and nrf3) using zebrafish embryos as a model system...
  8. Wang L, Gallagher E. Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. Toxicol Appl Pharmacol. 2013;266:177-86 pubmed publisher
    ..inducing protective cellular antioxidant genes via activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. However, the molecular mechanisms of Cd-induced olfactory injury have not been characterized...
  9. Li L, Kobayashi M, Kaneko H, Nakajima Takagi Y, Nakayama Y, Yamamoto M. Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish. J Biol Chem. 2008;283:3248-55 pubmed
    ..Keap1 facilitates the degradation of Nrf2, a transcription factor regulating the inducible expression of many cytoprotective genes...

More Information


  1. Voelker D, Vess C, Tillmann M, Nagel R, Otto G, Geisler R, et al. Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae. Aquat Toxicol. 2007;81:355-64 pubmed
    ..This study therefore indicates that gene expression analysis in DarT is able to reveal mechanistic information and may also be exploited for the development of replacement methods for chronic fish tests. ..
  2. Fang Q, Shi X, Zhang L, Wang Q, Wang X, Guo Y, et al. Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae. J Hazard Mater. 2015;283:897-904 pubmed publisher
    ..The results indicate that n-TiO2 enhanced the metabolism of PCP and caused oxidative damage and developmental toxicity, suggesting that NPs can influence the fate and toxicity of associated organic pollutants in the aquatic environment. ..
  3. Hahn M, McArthur A, Karchner S, Franks D, Jenny M, Timme Laragy A, et al. The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. PLoS ONE. 2014;9:e113158 pubmed publisher
    ..developmental expression and inducibility of anti-oxidant defenses through activation of NF-E2-related factor 2 (NRF2) affect susceptibility to oxidants, but the embryonic response to oxidants is not well understood...
  4. Mukaigasa K, Nguyen L, Li L, Nakajima H, Yamamoto M, Kobayashi M. Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress. Mol Cell Biol. 2012;32:4455-61 pubmed publisher
    Transcription factor Nrf2 is considered a master regulator of antioxidant defense in mammals...
  5. Zheng J, Yuan S, Wu C, Lv Z, Zhu A. Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish. Aquat Toxicol. 2017;182:113-119 pubmed publisher
    ..Taken together, oxidative stress and immunotoxicity in the brain were more serious when fish were exposed to Cd in the evening than in the morning, highlighting the importance of circadian rhythm in Cd-induced neurotoxicity in fish. ..
  6. Bestman J, Stackley K, Rahn J, Williamson T, Chan S. The cellular and molecular progression of mitochondrial dysfunction induced by 2,4-dinitrophenol in developing zebrafish embryos. Differentiation. 2015;89:51-69 pubmed publisher
  7. Mukhopadhyay D, Srivastava R, Chattopadhyay A. Sodium fluoride generates ROS and alters transcription of genes for xenobiotic metabolizing enzymes in adult zebrafish (Danio rerio) liver: expression pattern of Nrf2/Keap1 (INrf2). Toxicol Mech Methods. 2015;25:364-73 pubmed publisher
    ..Q Oxidase 1 (Nqo1) and Heme Oxygenase 1 (Ho-1) increased along with nuclear factor (erythroid-derived 2)-like 2 (Nrf2) whereas Kelch-like ECH-associated protein 1 (Keap1) decreased in the treated groups in comparison to their ..
  8. Knecht A, Goodale B, Truong L, Simonich M, Swanson A, Matzke M, et al. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol Appl Pharmacol. 2013;271:266-75 pubmed publisher
    ..Comprehensive in vivo characterization of 38 structurally diverse OPAHs indicated differential AHR dependency and a prominent role for oxidative stress in the toxicity mechanisms...
  9. Hu Y, Ma H, Zou Z, He K, Xiao Y, Wang Y, et al. Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress. Biomed Pharmacother. 2017;85:313-322 pubmed publisher
    ..enzymes NAD(P)H/quinone oxidoreductase 1 (NQO1) through activating the nuclear factor erythroid-2 related factor 2 (Nrf2)...
  10. da Rocha A, Ferreira J, Barros D, Pereira T, Bogo M, Oliveira S, et al. Gene expression and biochemical responses in brain of zebrafish Danio rerio exposed to organic nanomaterials: carbon nanotubes (SWCNT) and fullerenol (C60(OH)18-22(OK4)). Comp Biochem Physiol A Mol Integr Physiol. 2013;165:460-7 pubmed publisher
    ..0mg/L). Few biological responses were altered by this NM: decrease in total antioxidant capacity and induction of the expression of the transcription factor Nrf2 when compared to control group.
  11. Fuse Y, Nakajima H, Nakajima Takagi Y, Nakajima O, Kobayashi M. Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1. Genes Cells. 2015;20:590-600 pubmed publisher
    ..We previously showed that the Nrf2a-mediated induction of zebrafish hmox1a was liver specific and transient...
  12. Wu B, Yuan R, Chang Y, Lien H, Chen T, Chien H, et al. Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2. Biochem Biophys Res Commun. 2016;477:283-9 pubmed publisher
    ..Using a luciferase reporter assay in the zebrafish, we confirmed that EC could activate Nrf2-dependent antioxidant responses to significantly increase the ARE-controlled expression of luciferase reporter gene...
  13. Weil M, Scholz S, Zimmer M, Sacher F, Duis K. Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the fish early life stage test. Environ Toxicol Chem. 2009;28:1970-8 pubmed publisher
    ..The results of the present study indicate that gene expression analysis in zebrafish embryos could principally be used to predict effect concentrations in the fish early life stage test. ..
  14. Thomas J, Janz D. Embryo Microinjection of Selenomethionine Reduces Hatchability and Modifies Oxidant Responsive Gene Expression in Zebrafish. Sci Rep. 2016;6:26520 pubmed publisher
    ..modified gene expression of oxidant-responsive transcription factors (nuclear factor erythroid 2-related factor nrf2a and nrf2b), and enzymes involved in cellular methylation (methionine adenosyltransferase mat1a and mat2ab) in ..
  15. Zheng J, Yuan S, Wu C, Lv Z. Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio). Aquat Toxicol. 2016;180:36-44 pubmed publisher
    ..Furthermore, we also found a dramatic increase in mRNA levels of NF-E2-related factor 2 (Nrf2) and nuclear transcription factor ?B (NF-?B) at 24h in the liver and ovary...
  16. Holowiecki A, O Shields B, Jenny M. Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Toxicol Appl Pharmacol. 2016;311:74-87 pubmed publisher
    ..Knockdown of Nrf2a, a transcriptional regulator of hmox1a, was demonstrated to inhibit the Cd-mediated induction of hmox1b and bvrb...
  17. Nguyen V, Fuse Y, Tamaoki J, Akiyama S, Muratani M, Tamaru Y, et al. Conservation of the Nrf2-Mediated Gene Regulation of Proteasome Subunits and Glucose Metabolism in Zebrafish. Oxid Med Cell Longev. 2016;2016:5720574 pubmed publisher
    The Keap1-Nrf2 system is an evolutionarily conserved defense mechanism against oxidative and xenobiotic stress...
  18. de Peralta M, Mouguelar V, Sdrigotti M, Ishiy F, Fanganiello R, Passos Bueno M, et al. Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes. Cell Death Dis. 2016;7:e2397 pubmed publisher
    ..Based on this, we suggest CNBP as an additional target for new alternative therapeutic treatments to reduce craniofacial defects not only in TCS but also in other neurocristopathies. ..
  19. Corrales J, Kristofco L, Steele W, Saari G, Kostal J, Williams E, et al. Toward the Design of Less Hazardous Chemicals: Exploring Comparative Oxidative Stress in Two Common Animal Models. Chem Res Toxicol. 2017;30:893-904 pubmed publisher
    ..Antioxidant gene expression (changes in nrf2, gclc, gst, and sod) was most significantly (p < 0...
  20. Sarkar S, Mukherjee S, Chattopadhyay A, Bhattacharya S. Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: expression of antioxidant genes. Ecotoxicol Environ Saf. 2014;107:1-8 pubmed publisher
    ..Moreover, enhanced mRNA level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in As2O3 exposed zebrafish indicates a protective role of Nrf2...
  21. Sarkar S, Mukherjee S, Chattopadhyay A, Bhattacharya S. Differential modulation of cellular antioxidant status in zebrafish liver and kidney exposed to low dose arsenic trioxide. Ecotoxicol Environ Saf. 2017;135:173-182 pubmed publisher
    ..The pattern of mRNA expression of Nrf2 was not uniform and was in accordance to its downstream antioxidant genes...
  22. Mukhopadhyay D, Priya P, Chattopadhyay A. Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1. Environ Toxicol Pharmacol. 2015;40:352-9 pubmed publisher
    ..Expression of mRNA of nuclear factor erythroid 2 related factor 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein 1 (Keap1) during stress condition ..
  23. Ramsden R, Gallagher E. Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets. Redox Biol. 2016;9:114-123 pubmed publisher
    The transcription factor NFE2L2 (Nuclear Factor, Erythroid 2-Like 2, or NRF2) plays a key role in maintaining the redox state within cells...
  24. Mottaz H, Schönenberger R, Fischer S, Eggen R, Schirmer K, Groh K. Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish. Environ Pollut. 2017;221:105-115 pubmed publisher
  25. Zhu Q, Guo S, Yuan S, Lv Z, Zheng J, Xia H. Heat indicators of oxidative stress, inflammation and metal transport show dependence of cadmium pollution history in the liver of female zebrafish. Aquat Toxicol. 2017;191:1-9 pubmed publisher
    ..activity of Cu/Zn-SOD, CAT and iNOS; LPO; MT protein), 8 molecular indicators of oxidative stress (mRNA levels of Nrf2, Cu/Zn-SOD, CAT, HSF1, HSF2, HSP70, MTF-1 and MT), 5 molecular indicators of inflammation (mRNA levels of IL-6, IL-..
  26. Xu H, Yang M, Qiu W, Pan C, Wu M. The impact of endocrine-disrupting chemicals on oxidative stress and innate immune response in zebrafish embryos. Environ Toxicol Chem. 2013;32:1793-9 pubmed publisher
    ..The authors' results demonstrate that exposure to BPA and NP significantly affects the expression of genes related to immune response in zebrafish embryos following oxidative stress. ..
  27. Liu H, Gooneratne R, Huang X, Lai R, Wei J, Wang W. A rapid in vivo zebrafish model to elucidate oxidative stress-mediated PCB126-induced apoptosis and developmental toxicity. Free Radic Biol Med. 2015;84:91-102 pubmed publisher
    ..In the present study, an in vivo zebrafish model of nrf2a fused to enhanced green fluorescent protein (nrf2a-eGFP) was constructed...
  28. Su Y, Chiu H, Hung J, Hong J. Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. Apoptosis. 2014;19:1457-70 pubmed publisher
    ..Increased oxidative stress, as evidenced by the up-regulation of Mn SOD, catalase, and Nrf2, was also observed during this period...
  29. Zhang S, Xu M, Huang J, Tang L, Zhang Y, Wu J, et al. Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish. Dis Model Mech. 2014;7:837-45 pubmed publisher
    ..Zebrafish bach1b, nrf2a and mafK are all expressed in the zebrafish exocrine pancreas...
  30. Dale K, Rasinger J, Thorstensen K, Penglase S, Ellingsen S. Vitamin E reduces endosulfan-induced toxic effects on morphology and behavior in early development of zebrafish (Danio rerio). Food Chem Toxicol. 2017;101:84-93 pubmed publisher
    ..These results demonstrate that α-TOC protects against phenotypic and behavioral effects caused by ESF but did not rescue ESF-induced aberrations in antioxidant gene expression. ..
  31. Miller G, Labut E, Lebold K, Floeter A, Tanguay R, Traber M. Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. J Nutr Biochem. 2012;23:478-86 pubmed publisher
    ..05) at 120 h post-fertillization than embryos from parents fed E+ or lab diets. This study documents for the first time that vitamin E is essential for normal zebrafish embryonic development. ..
  32. Fuse Y, Nguyen V, Kobayashi M. Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish. Toxicol Appl Pharmacol. 2016;305:136-142 pubmed publisher
    ..investigated the protective role of Nrf2 against acute sodium arsenite toxicity using the zebrafish Nrf2 mutant, nrf2a(fh318)...
  33. Liao G, Li R, Chen X, Zhang W, Du S, Yuan Y. Sodium valproate prevents radiation-induced injury in hippocampal neurons via activation of the Nrf2/HO-1 pathway. Neuroscience. 2016;331:40-51 pubmed publisher
    ..The expression of nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was also measured...
  34. Sant K, Hansen J, Williams L, Tran N, Goldstone J, Stegeman J, et al. The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biol. 2017;13:207-218 pubmed publisher
    ..factors, morpholino oligonucleotides were used to knock down translation of Nrf1 and Nrf2 (nrf1a, nrf1b, nrf2a, nrf2b). Knockdown of Nrf1a or Nrf1b perturbed glutathione redox state until 72 hpf...
  35. Massarsky A, Bone A, Dong W, Hinton D, Prasad G, Di Giulio R. AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos. Toxicol Appl Pharmacol. 2016;309:63-76 pubmed publisher
    ..TPM exposures were performed in embryos that were microinjected with nuclear factor erythroid 2-related factor 2 (Nrf2), AHR2, cytochrome P450 1A (CYP1A), or CYP1B1 morpholinos, and deformities were assessed...
  36. Yuan S, Lv Z, Zhu A, Zheng J, Wu C. Negative effect of chronic cadmium exposure on growth, histology, ultrastructure, antioxidant and innate immune responses in the liver of zebrafish: Preventive role of blue light emitting diodes. Ecotoxicol Environ Saf. 2017;139:18-26 pubmed publisher
    ..exposure alone dramatically enhanced mRNA levels of nuclear transcription factor ?B (NF-?B) and E2-related factor (Nrf2). However, compared to Cd exposure alone, Cd exposure in combination with LDB apparently down-regulated both genes...
  37. Nornberg B, Batista C, Almeida D, Trindade G, Marins L. ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells. Toxicol In Vitro. 2015;29:204-10 pubmed publisher
    ..These data provide useful insights for better understanding of MP detoxification mechanism in fish hepatocytes. ..
  38. Shi X, Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci. 2010;115:391-400 pubmed publisher
    ..In the present study, we examined nuclear factor erythroid 2-related factor 2 (Nrf2)- and mitogen-activated protein kinases (MAPKs)-mediated oxidative stress pathways in zebrafish embryos upon ..
  39. Timme Laragy A, Sant K, Rousseau M, diIorio P. Deviant development of pancreatic beta cells from embryonic exposure to PCB-126 in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2015;178:25-32 pubmed publisher
    ..As we recently showed the transcription factor Nrf2a is protective in PCB-126 embryotoxicity, we then assessed the transcriptional function of the islets in wildtype ..
  40. Zheng J, Yuan S, Wu C, Li W. Chronic waterborne zinc and cadmium exposures induced different responses towards oxidative stress in the liver of zebrafish. Aquat Toxicol. 2016;177:261-8 pubmed publisher
    ..Furthermore, transcription factor NF-E2-related factor 2 (Nrf2) expression parelleled with its target genes, suggesting that Nrf2 is required for the protracted induction of ..
  41. Chen Q, Sun Y, Liu Z, Li Y. Sex-dependent effects of subacute mercuric chloride exposure on histology, antioxidant status and immune-related gene expression in the liver of adult zebrafish (Danio rerio). Chemosphere. 2017;188:1-9 pubmed publisher
    ..the decrease in cat1 expression and the increase in GST activity, GSH and MDA contents as well as gpx1a, gstr, nrf2 and keap1 mRNA levels were observed in Hg2+-exposed groups, but the activities of CAT, SOD and GPX were ..
  42. Behra M, Gallardo V, Bradsher J, Torrado A, Elkahloun A, Idol J, et al. Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line. BMC Dev Biol. 2012;12:6 pubmed publisher
    ..This will prove to be a valuable tool for the study of regeneration in the lateral line of zebrafish in particular and for regeneration of neuroepithelia in general. ..
  43. Zhang Q, Li Y, Liu Z, Chen Q. Exposure to mercuric chloride induces developmental damage, oxidative stress and immunotoxicity in zebrafish embryos-larvae. Aquat Toxicol. 2016;181:76-85 pubmed publisher
    ..and GPX) activities, endogenous GSH and MDA contents, as well as the mRNA levels of genes (cat1, sod1, gstr, gpx1a, nrf2, keap1, hsp70 and mt) encoding antioxidant proteins...
  44. Liu H, Sheng N, Zhang W, Dai J. Toxic effects of perfluorononanoic acid on the development of Zebrafish (Danio rerio) embryos. J Environ Sci (China). 2015;32:26-34 pubmed publisher
    ..However, the mRNA expression levels of both ppara and pparg did not show any significant variation after exposure. These findings suggest that PFNA affected the development of zebrafish embryos at relatively low concentrations. ..
  45. Yuan S, Xu H, Liu L, Zheng J. Different effects of blue and red light-emitting diodes on antioxidant responses in the liver and ovary of zebrafish Danio rerio. Fish Physiol Biochem. 2017;43:411-419 pubmed publisher
    ..Furthermore, a sharp increase in expression of transcription factor Nrf2 that targets antioxidant genes was observed in the liver but not in the ovary under LDB and LDR conditions...
  46. Hidasi A, Groh K, Suter M, Schirmer K. Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations. Ecotoxicol Environ Saf. 2017;138:16-24 pubmed publisher
    ..This may reduce the chances of fish to survive in the environment, as their defense against pathogens is weakened. ..
  47. Hrubik J, Glisic B, Fa S, Pogrmic Majkic K, Andric N. Erk-Creb pathway suppresses glutathione-S-transferase pi expression under basal and oxidative stress conditions in zebrafish embryos. Toxicol Lett. 2016;240:81-92 pubmed publisher
    ..This study also provides a novel link between Erk and gstp1-2 expression, setting apart a possible differential regulation of gstp1-2 in adult and embryonic cells. ..
  48. Wu B, Yuan R, Lien H, Hung C, Hwang P, Chen R, et al. Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo. J Biomed Sci. 2016;23:25 pubmed publisher
    ..However, multiple signaling factors, such as Bcl2-L1, Nrf2, and GDNF, were found to effectively protect neuronal cells expressing tau-GFP from death...
  49. Zhu Y, Wang P, Zhao Y, Yang C, Clark A, Leung T, et al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016;95:243-54 pubmed publisher
    ..The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2 p45-related factor 2 (Nrf2) system is a major regulatory pathway of cytoprotective genes against oxidative and electrophilic stress...