Gene Symbol: nfe2
Description: nuclear factor, erythroid 2
Alias: transcription factor NF-E2 45 kDa subunit, nuclear factor (erythroid-derived 2), 45 kDa, nuclear factor protein, nuclear factor, erythroid-derived 2
Pratt S, Drejer A, Foott H, Barut B, Brownlie A, Postlethwait J, et al
. Isolation and characterization of zebrafish NFE2. Physiol Genomics. 2002;11:91-8 pubmed
..Mammalian p45-NFE2 was characterized for its ability to bind the hypersensitive sites of the globin locus control region...
Timme Laragy A, Karchner S, Franks D, Jenny M, Harbeitner R, Goldstone J, et al
. Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). J Biol Chem. 2012;287:4609-27 pubmed publisher
..The identification of zebrafish nrf2 co-orthologs will facilitate new understanding of the multiple roles of NRF2 in protecting vertebrate embryos from oxidative damage. ..
Takagi Y, Kobayashi M, Li L, Suzuki T, Nishikawa K, Yamamoto M. MafT, a new member of the small Maf protein family in zebrafish. Biochem Biophys Res Commun. 2004;320:62-9 pubmed
..MafT protein bound MARE sequence as a homodimer or heterodimers with zebrafish Nrf2 or p45 Nfe2. Co-overexpression of MafT and Nrf2 synergistically activated MARE-mediated gene expression in zebrafish embryos...
Ohashi K, Takizawa F, Tokumaru N, Nakayasu C, Toda H, Fischer U, et al
. A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes. Immunogenetics. 2010;62:543-59 pubmed publisher
..The ITAM-bearing of G6F-like suggests that the molecule plays an important role in cell activation, and G6F-like expression by erythrocytes suggests that these cells have functional overlap potential with thrombocytes...
Patil P, Uechi T, Kenmochi N. Incomplete splicing of neutrophil-specific genes affects neutrophil development in a zebrafish model of poikiloderma with neutropenia. RNA Biol. 2015;12:426-34 pubmed publisher
..This zebrafish model could serve as a valuable tool to investigate the causative role of USB1 in PN pathogenesis. ..
Ramsden R, Gallagher E. Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets. Redox Biol. 2016;9:114-123 pubmed publisher
Williams L, Lago B, McArthur A, Raphenya A, Pray N, Saleem N, et al
. The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development. Aquat Toxicol. 2016;180:141-154 pubmed publisher
..exposure, members of the Cap'n'Collar (CNC) basic leucine zipper (b-ZIP) transcription factor family (including Nfe2 and Nfe2-related factors, Nrfs) activate the expression of genes whose protein products contribute to reduced ..
Lin Q, Zhou R, Zheng Y, Zhao L, Huang M, Zhang X, et al
. Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 2017;31:1206-1216 pubmed publisher
..Together with Tg(mpl:eGFP)smu4, mpl mutant zebrafish provide a useful tool for drug screening and study of thrombocytopoiesis. ..
Williams L, Timme Laragy A, Goldstone J, McArthur A, Stegeman J, Smolowitz R, et al
. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS ONE. 2013;8:e79574 pubmed publisher
Transcription factors in the CNC-bZIP family (NFE2, NRF1, NRF2 and NRF3) regulate genes with a wide range of functions in response to both physiological and exogenous signals, including those indicating changes in cellular redox status...