Gene Symbol: neurod4
Description: neuronal differentiation 4
Alias: ath3, zath3, neurogenic differentiation factor 4, atonal-like 3, neurogenic differentiation 4
Species: zebrafish
Products:     neurod4

Top Publications

  1. Bae Y, Shimizu T, Hibi M. Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Development. 2005;132:1375-85 pubmed
    ..These data indicate that her3 and her9 function as prepattern genes that link the positional dorsoventral polarity information in the posterior neuroectoderm to the spatial regulation of neurogenesis. ..
  2. Dorsemans A, Soulé S, Weger M, Bourdon E, Lefebvre d Hellencourt C, Meilhac O, et al. Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish. J Comp Neurol. 2017;525:442-458 pubmed publisher
    ..In addition, our study reinforces the utility of zebrafish as a robust model for studying the effects of metabolic disorders on the central nervous system. J. Comp. Neurol. 525:442-458, 2017. © 2016 Wiley Periodicals, Inc. ..
  3. Sapede D, Dyballa S, Pujades C. Cell lineage analysis reveals three different progenitor pools for neurosensory elements in the otic vesicle. J Neurosci. 2012;32:16424-34 pubmed publisher
  4. Halluin C, Madelaine R, Naye F, Peers B, Roussigne M, Blader P. Habenular Neurogenesis in Zebrafish Is Regulated by a Hedgehog, Pax6 Proneural Gene Cascade. PLoS ONE. 2016;11:e0158210 pubmed publisher
    ..the homeobox transcription factor Pax6a and the redundant action of two proneural bHLH factors, Neurog1 and Neurod4. We present evidence that Hedgehog signalling is required for the expression of pax6a, which is in turn necessary ..
  5. Ke Z, Kondrichin I, Gong Z, Korzh V. Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Mol Cell Neurosci. 2008;37:388-401 pubmed
    ..Gli2b acts in cell proliferation and plays an early role in the hindbrain within a regulatory cascade involving Notch and Ngn1, as well as a role as specific activator in rhombomere 4. ..
  6. Best C, Kurrasch D, Vijayan M. Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish. Sci Rep. 2017;7:40905 pubmed publisher
    ..Also, cortisol increased the expression of the proneural gene neurod4, a marker of neurogenesis, in a region- and development-specific manner in the embryos...
  7. Gonzalez Quevedo R, Lee Y, Poss K, Wilkinson D. Neuronal regulation of the spatial patterning of neurogenesis. Dev Cell. 2010;18:136-47 pubmed publisher
    ..Fgf20a mutants have ectopic neurogenesis and lack the segment center progenitor population. Our findings reveal how signaling from neurons induces formation of a nonneurogenic zone of neural progenitors. ..
  8. Yao S, Cheng M, Zhang Q, Wasik M, Kelsh R, Winkler C. Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish. PLoS ONE. 2013;8:e63757 pubmed publisher
    ..These data indicate that tightly controlled alk expression is critical for the balance between neural progenitor proliferation, differentiation and survival during embryonic neurogenesis...
  9. Geling A, Plessy C, Rastegar S, Strahle U, Bally Cuif L. Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of Notch to inhibit neurogenesis at the midbrain-hindbrain boundary. Development. 2004;131:1993-2006 pubmed
    ..Together our data demonstrate a role of Her5 as a prepattern factor in the spatial definition of proneural domains in the zebrafish neural plate, in a manner similar to its Drosophila homologue Hairy. ..

More Information


  1. Bayramli X, Kocagoz Y, Sakizli U, Fuss S. Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons. Sci Rep. 2017;7:5572 pubmed publisher
    ..We formulated a simple mathematical model based on exact parameters derived from our analysis of OSN neurogenesis, which accurately generates OR-like distributions without the need to invoke molecular signals to pattern the OE. ..
  2. Yeh C, Kao S, Cheng Y, Hsu L. Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression. J Biol Chem. 2013;288:27927-39 pubmed publisher
    ..Our findings provide the first functional characterization of cdk10 in vertebrate development and reveal its critical function in neurogenesis by modulation of raf1a expression. ..
  3. Wang X, Emelyanov A, Korzh V, Gong Z. Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development. Dev Dyn. 2003;227:587-92 pubmed
    ..Here, we isolated a zebrafish homologue, named zath3, and analyzed its expression pattern in zebrafish embryos...
  4. Frohnhöfer H, Geiger Rudolph S, Pattky M, Meixner M, Huhn C, Maischein H, et al. Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish. Biol Open. 2016;5:736-44 pubmed publisher
    ..8, Cx39.4, and Kir7.1, an inwardly rectifying potassium channel, all known to be regulated by polyamines. Thus, zebrafish provide a vertebrate model to study the in vivo effects of polyamines. ..
  5. Madelaine R, Garric L, Blader P. Partially redundant proneural function reveals the importance of timing during zebrafish olfactory neurogenesis. Development. 2011;138:4753-62 pubmed publisher
    ..Here, we show that the zebrafish Atonal genes neurogenin1 (neurog1) and neurod4 are redundantly required for development of both early-born olfactory neurons (EONs) and later-born olfactory ..
  6. Park S, Yeo S, Yoo K, Hong S, Lee S, Rhee M, et al. Zath3, a neural basic helix-loop-helix gene, regulates early neurogenesis in the zebrafish. Biochem Biophys Res Commun. 2003;308:184-90 pubmed
    We have isolated a basic helix-loop-helix (bHLH) gene homologous to the Drosophila proneural gene atonal, termed zath3, from zebrafish. zath3 is expressed in neurons of the central nervous system and in subsets of cranial ganglia...
  7. Flasse L, Pirson J, Stern D, Von Berg V, Manfroid I, Peers B, et al. Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biol. 2013;11:78 pubmed publisher
    ..It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state...
  8. Miyake A, Nihno S, Murakoshi Y, Satsuka A, Nakayama Y, Itoh N. Neucrin, a novel secreted antagonist of canonical Wnt signaling, plays roles in developing neural tissues in zebrafish. Mech Dev. 2012;128:577-90 pubmed publisher
    ..Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues and plays roles in neural development in zebrafish. ..
  9. Harrison M, Georgiou A, Spaink H, Cunliffe V. The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos. BMC Genomics. 2011;12:24 pubmed publisher
    ..neuronal specification and CNS patterning, including the proneural bHLH proteins Ascl1a and Ascl1b, as well as Neurod4 and Neurod...
  10. Uribe R, Gross J. Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics. Development. 2010;137:3763-74 pubmed publisher
  11. Kim H, Kim E, Yoo K, Lee M, Choi J, Park H, et al. Isolation and expression analysis of Alzheimer's disease-related gene xb51 in zebrafish. Dev Dyn. 2008;237:3921-6 pubmed publisher
    ..domain of xb51 in the dorsal telencephalon was defined by several molecular markers: emx1, dlx2, lim1, islet1, neurod4/zath3, ngn1, her4, and elavl3/huC...
  12. Seritrakul P, Gross J. Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways. PLoS Genet. 2017;13:e1006987 pubmed publisher
  13. Radosevic M, Robert Moreno A, Coolen M, Bally Cuif L, Alsina B. Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear. Development. 2011;138:397-408 pubmed publisher
    ..These findings permit modeling of the complex genetic cascade that underlies neural patterning of the otic vesicle. ..
  14. Yeo S, Kim M, Kim H, Huh T, Chitnis A. Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos. Dev Biol. 2007;301:555-67 pubmed
    ..The establishment of a reporter line with Notch-Su(H)-dependent fluorescent gene expression provides a tool to explore the complex role of Notch signaling in the development of vertebrate nervous system. ..
  15. Thompson W, Arnold V, Vijayan M. Venlafaxine in Embryos Stimulates Neurogenesis and Disrupts Larval Behavior in Zebrafish. Environ Sci Technol. 2017;51:12889-12897 pubmed publisher
    ..Overall, zygotic exposure to venlafaxine disrupts early development, including brain function, and compromises larval behavior, suggesting impact of this drug on developmental programming in zebrafish. ..
  16. Sapede D, Pujades C. Hedgehog signaling governs the development of otic sensory epithelium and its associated innervation in zebrafish. J Neurosci. 2010;30:3612-23 pubmed publisher
    ..These results lead to a model in which Hh orients functionally the development of inner ear towards an auditory fate in all vertebrate species. ..
  17. Loponte S, Segré C, Senese S, Miccolo C, Santaguida S, Deflorian G, et al. Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Sci Rep. 2016;6:30213 pubmed publisher
    ..Our data represent a step towards the comprehension of HDAC1 regulation by its PTM code, with important implications in unravelling its roles both in physiology and pathology. ..
  18. Wardle F, Odom D, Bell G, Yuan B, Danford T, Wiellette E, et al. Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome Biol. 2006;7:R71 pubmed
    ..This approach will allow investigators to determine the genomic binding locations of DNA interacting proteins during development and expedite the assembly of the genetic networks that regulate embryogenesis. ..
  19. Serifi I, Tzima E, Soupsana K, Karetsou Z, Beis D, Papamarcaki T. The zebrafish homologs of SET/I2PP2A oncoprotein: expression patterns and insights into their physiological roles during development. Biochem J. 2016;473:4609-4627 pubmed
    ..Collectively, our results suggest that seta and setb are required during embryogenesis and play roles in the zebrafish sensory system development. ..