Gene Symbol: ndrg4
Description: NDRG family member 4
Alias: si:ch211-194m7.2, zgc:136766, protein NDRG4, N-myc downstream regulated gene 4
Qu X, Jia H, Garrity D, Tompkins K, Batts L, Appel B, et al
. Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol. 2008;317:486-96 pubmed publisher
b>NDRG4 is a novel member of the NDRG family (N-myc downstream-regulated gene). The roles of NDRG4 in development have not previously been evaluated...
Sedletcaia A, Evans T. Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes. Dev Dyn. 2011;240:1548-57 pubmed publisher
..Therefore, in zebrafish, two tbx2 genes are functionally redundant for regulating chamber development, while each gene is required independently for development of the AVC. ..
Balci T, Prykhozhij S, Teh E, Da as S, McBride E, Liwski R, et al
. A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis. Br J Haematol. 2014;167:48-61 pubmed publisher
..This study represents the first zebrafish model of a mast cell disease with an aggressive adult phenotype and embryonic markers that could be exploited to screen for novel agents in SM. ..
Li F, Wang H, Liu J, Lin J, Zeng A, Ai W, et al
. Immunotoxicity of ?-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. PLoS ONE. 2016;11:e0152530 pubmed publisher
..These complex effects of DKAs may lead to zebrafish dysfunction and occurrence of diseases related to the immune system. ..
Li R, Traver D, Matthes T, Bertrand J. Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish. Blood. 2016;128:3052-3060 pubmed publisher
Fontenas L, De Santis F, Di Donato V, Degerny C, Chambraud B, Del Bene F, et al
. Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish. PLoS Genet. 2016;12:e1006459 pubmed publisher
..We have identified N-myc downstream-regulated gene 4, ndrg4, as a novel factor that regulates sodium channel clustering in zebrafish...
Lefebvre K, Tilton S, Bammler T, Beyer R, Srinouanprachan S, Stapleton P, et al
. Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Toxicol Sci. 2009;107:65-77 pubmed publisher
..Further, potential molecular biomarkers of neuropathic injury, including the zebrafish homolog of human NDRG4, were identified and may be relevant to DA exposure levels below that causing neurobehavioral injury...
Mullally M, Albrecht C, Horton M, Laboissonniere L, Goetz J, Chowdhury R, et al
. Expression Profiling of Developing Zebrafish Retinal Cells. Zebrafish. 2016;13:272-80 pubmed publisher
..Further analysis of these profiles will reveal genes that can be mutated using genome editing techniques. Together these studies increase our knowledge of the genes driving development of different cell types in the zebrafish retina. ..
D Aurizio R, Russo F, Chiavacci E, Baumgart M, Groth M, D Onofrio M, et al
. Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Front Bioeng Biotechnol. 2016;4:60 pubmed publisher
..This approach allowed to discover complex regulatory circuits involving novel miRNAs and protein coding genes not considered before in the HOS such as miR-34a and miR-30 and their targets. ..