Gene Symbol: ncam1a
Description: neural cell adhesion molecule 1a
Alias: fj56g09, ncam, ncam1, wu:fj56g09, neural cell adhesion molecule 1
Species: zebrafish
Products:     ncam1a

Top Publications

  1. Kustermann S, Hildebrandt H, Bolz S, Dengler K, Kohler K. Genesis of rods in the zebrafish retina occurs in a microenvironment provided by polysialic acid-expressing Müller glia. J Comp Neurol. 2010;518:636-46 pubmed publisher
    Polysialic acid (polySia) is a posttranslational modification of the neural cell adhesion molecule NCAM, which in the vertebrate brain is dynamically regulated during development and crucially involved in developmental and adult ..
  2. Becker T, Becker C, Schachner M, Bernhardt R. Antibody to the HNK-1 glycoepitope affects fasciculation and axonal pathfinding in the developing posterior lateral line nerve of embryonic zebrafish. Mech Dev. 2001;109:37-49 pubmed
    ..We suggest that the HNK-1 glycoepitope is an important modulator of embryonic nerve growth...
  3. Langhauser M, Ustinova J, Rivera Milla E, Ivannikov D, Seidl C, Slomka C, et al. Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system. Glycobiology. 2012;22:196-209 pubmed publisher
    ..Within the ncam1 cluster, teleost fishes express ncam1a (ncam) and ncam1b (pcam) as duplicated paralogs which arose from a second round of ray-finned fish-specific genome ..
  4. Wang X, Ren J, Wang Z, Yao J, Fei J. NRSF/REST is required for gastrulation and neurogenesis during zebrafish development. Acta Biochim Biophys Sin (Shanghai). 2012;44:385-93 pubmed publisher
    ..Our results showed that REST (especially maternal supplied REST) was required for gastrulation and neurogenesis during zebrafish early embryogenesis. ..
  5. Suzuki H, Nikaido M, Hagino Yamagishi K, Okada N. Distinct functions of two olfactory marker protein genes derived from teleost-specific whole genome duplication. BMC Evol Biol. 2015;15:245 pubmed publisher
    ..This study provides a good example for analyzing a functional subdivision of the teleost OE and eyes as revealed by 3R-derived paralogs of OMPs. ..
  6. Becker T, Bernhardt R, Reinhard E, Wullimann M, Tongiorgi E, Schachner M. Readiness of zebrafish brain neurons to regenerate a spinal axon correlates with differential expression of specific cell recognition molecules. J Neurosci. 1998;18:5789-803 pubmed
    ..1, L1.2, and neural cell adhesion molecule (NCAM) after a rostral (proximal) or caudal (distal) spinal cord transection in adult zebrafish...
  7. Peng K, Li Y, Long L, Li D, Jia Q, Wang Y, et al. Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish. Neurosci Lett. 2010;484:98-103 pubmed publisher
    ..Our results indicated that FoxO3a might be essential for the maintenance of neural development in zebrafish. Therefore, this work provides novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals. ..
  8. Pradel G, Schmidt R, Schachner M. Involvement of L1.1 in memory consolidation after active avoidance conditioning in zebrafish. J Neurobiol. 2000;43:389-403 pubmed
    To investigate the involvement of the cell adhesion molecules L1.1, L1.2, NCAM, and tenascin-C in memory formation, zebrafish (Brachydanio rerio) were trained in an active avoidance paradigm to cross a hurdle to avoid mild electric shocks ..
  9. Rieger S, Volkmann K, Köster R. Polysialyltransferase expression is linked to neuronal migration in the developing and adult zebrafish. Dev Dyn. 2008;237:276-85 pubmed
    ..can be obtained by the enzymatic attachment of polysialic acid (PSA) to the neural cell adhesion molecule (NCAM) by means of the polysialyltransferases STX and PST...

More Information


  1. Bernhardt R, Tongiorgi E, Anzini P, Schachner M. Increased expression of specific recognition molecules by retinal ganglion cells and by optic pathway glia accompanies the successful regeneration of retinal axons in adult zebrafish. J Comp Neurol. 1996;376:253-64 pubmed
    ..1, 11.2, n-cam and beta 3 but not for tn-c. The combination of a neuronal (intrinsic) response to axotomy with an environmental (extrinsic) response may be an important determinant allowing for the successful axonal regeneration. ..
  2. Bernhardt R. Cellular and molecular bases of axonal pathfinding during embryogenesis of the fish central nervous system. J Neurobiol. 1999;38:137-60 pubmed
    ..Experimental evidence for the functions of these molecules in the zebrafish nervous system is accumulating. In the future, this analysis is expected to profit greatly from genetic screens that have recently been initiated. ..
  3. Bertrand J, Kim A, Teng S, Traver D. CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development. 2008;135:1853-62 pubmed publisher
    ..Together, these studies suggest that expression of CD41 and cmyb marks nascent HSCs in the zebrafish AGM, and provide the means to further dissect HSC generation and function in the early vertebrate embryo. ..
  4. Pei W, Feldman B. Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia. Dev Biol. 2009;326:201-11 pubmed publisher
    ..In summary, we find that MB arises after gastrulation in regions that fail to express wnt5b, and we show that two complex dysmorphologies - MB and cyclopia - can be promoted by either common or unique risk factors. ..
  5. Aleksejeva E, Houel A, Briolat V, Levraud J, Langevin C, Boudinot P. Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses. Dev Comp Immunol. 2016;57:48-56 pubmed publisher
    ..Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms. ..
  6. Brown K, Keller P, Ramialison M, Rembold M, Stelzer E, Loosli F, et al. Nlcam modulates midline convergence during anterior neural plate morphogenesis. Dev Biol. 2010;339:14-25 pubmed publisher
  7. Hörnberg H, Cioni J, Harris W, Holt C. Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1. J Neurosci. 2016;36:12697-12706 pubmed
    ..We characterize a novel RNA-based mechanism by which axons restrict their translatome developmentally to achieve proper targeting. ..