myl4

Summary

Gene Symbol: myl4
Description: myosin, light chain 4, alkali; atrial, embryonic
Alias: im:7136900, zgc:114164, myosin light chain 4, slow skeletal ventricular myosin alkali light chain 3-like
Species: zebrafish

Top Publications

  1. Chen Z, Huang W, Dahme T, Rottbauer W, Ackerman M, Xu X. Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms. Cardiovasc Res. 2008;79:97-108 pubmed publisher
    ..RLCs may have distinct pathological characteristics during disease progression. ..
  2. Orr N, Arnaout R, Gula L, Spears D, Leong Sit P, Li Q, et al. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016;7:11303 pubmed publisher
    ..Glu11Lys mutation in the atrial-specific myosin light chain gene MYL4. In zebrafish, mutant MYL4 leads to disruption of sarcomeric structure, atrial enlargement and electrical ..
  3. Sugden W, Meissner R, Aegerter Wilmsen T, Tsaryk R, Leonard E, Bussmann J, et al. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol. 2017;19:653-665 pubmed publisher
    ..Together, our data suggest that cell shape changes in response to biophysical cues act as an underlying principle allowing for the ordered patterning of tubular organs. ..