Gene Symbol: myh9a
Description: myosin, heavy chain 9a, non-muscle
Alias: fi22c04, myh9, myh9l2, wu:fi22c04, wu:fj85e11, zgc:162029, zgc:66164, myosin-9, fj85e11, myosin heavy chain IX, myosin, heavy chain 9, non-muscle, like-2, myosin, heavy polypeptide 9, non-muscle, myosin, heavy polypeptide 9a, non-muscle, zNMHC-IIA
Species: zebrafish
Products:     myh9a

Top Publications

  1. Müller T, Rumpel E, Hradetzky S, Bollig F, Wegner H, Blumenthal A, et al. Non-muscle myosin IIA is required for the development of the zebrafish glomerulus. Kidney Int. 2011;80:1055-63 pubmed publisher
    Mutations in the MYH9 gene, coding for the non-muscle myosin heavy chain IIA (NMHC-IIA), are responsible for syndromes characterized by macrothrombocytopenia associated with deafness, cataracts, and severe glomerular disease...
  2. Ignatius M, Chen E, Elpek N, Fuller A, Tenente I, Clagg R, et al. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer Cell. 2012;21:680-93 pubmed publisher
    ..Our data suggest that non-tumor-propagating cells likely have important supportive roles in cancer progression and facilitate metastasis. ..
  3. Kotb A, Müller T, Xie J, Anand Apte B, Endlich K, Endlich N. Simultaneous assessment of glomerular filtration and barrier function in live zebrafish. Am J Physiol Renal Physiol. 2014;307:F1427-34 pubmed publisher
    ..In summary, we present a novel method that allows to simultaneously assess glomerular filtration and barrier function in live zebrafish. ..
  4. Gutzman J, Sahu S, Kwas C. Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis. Dev Biol. 2015;397:103-15 pubmed publisher
    ..NMIIA and NMIIB knockdown also correlated with abnormal distribution of actin within the cells of the MHBC. Thus, NMIIA and NMIIB perform distinct functions in regulating cell shape during MHB morphogenesis. ..
  5. Anderson B, Howell D, Soldano K, Garrett M, Katsanis N, Telen M, et al. In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. PLoS Genet. 2015;11:e1005349 pubmed publisher
    ..In sickle cell disease (SCD) patients, we reported previously a genetic interaction between APOL1 and MYH9. Testing this interaction in vivo by co-suppressing both transcripts yielded no additive effects...
  6. Tsai H, Hamilton A, Tinch A, Guy D, Gharbi K, Stear M, et al. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. BMC Genomics. 2015;16:969 pubmed publisher
    ..The results have practical relevance for genomic selection in salmon and may also provide insight into variation in the identified genes underpinning body growth and development in salmonid species. ..
  7. Takacs C, Giraldez A. miR-430 regulates oriented cell division during neural tube development in zebrafish. Dev Biol. 2016;409:442-50 pubmed publisher
    ..We propose that miR-430, independently of canonical apicobasal and planar cell polarity (PCP) pathways, coordinates the stereotypical cell divisions that instruct neural tube morphogenesis. ..
  8. Blaser H, Reichman Fried M, Castanon I, Dumstrei K, Marlow F, Kawakami K, et al. Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow. Dev Cell. 2006;11:613-27 pubmed
    ..The biased formation of new protrusions in a particular region of the cell in response to SDF-1 defines the leading edge and the direction of cell migration. ..
  9. Ikeda D, Ono Y, Snell P, Edwards Y, Elgar G, Watabe S. Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: evidence from comparative genomic analysis. Physiol Genomics. 2007;32:1-15 pubmed publisher
    ..Phylogenetic analysis suggests that fast skeletal MYHs evolved independently in teleosts and tetrapods after fast skeletal MYHs had diverged from four ancestral MYHs...

More Information


  1. Ernst S, Liu K, Agarwala S, Moratscheck N, Avci M, Dalle Nogare D, et al. Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish. Development. 2012;139:4571-81 pubmed publisher
    ..In conclusion, we uncovered the first mechanistic link between patterning and morphogenesis during LL sensory organ formation. ..
  2. Huang Y, Wang X, Wang X, Xu M, Liu M, Liu D. Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Gene Expr Patterns. 2013;13:265-70 pubmed publisher
    ..We also detected myh10 mRNA hybridization signal in 48 hpf zebrafish heart. In addition, we investigated myh9a and myh9b mRNA distribution in zebrafish developing embryos...
  3. Lou S, Diz Muñoz A, Weiner O, Fletcher D, Theriot J. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. J Cell Biol. 2015;209:275-88 pubmed publisher
    ..These results suggest a novel MLCK-specific mechanism for controlling cell polarity via regulation of myosin activity in protrusions. ..