Gene Symbol: myh11a
Description: myosin, heavy chain 11a, smooth muscle
Alias: myh11, myosin-11, meltdown, mlt, myosin, heavy polypeptide 11, smooth muscle a, smmhc, smooth muscle myosin heavy chain
Species: zebrafish

Top Publications

  1. Wallace K, Akhter S, Smith E, Lorent K, Pack M. Intestinal growth and differentiation in zebrafish. Mech Dev. 2005;122:157-73 pubmed
    ..Analysis of zebrafish mutants with altered epithelial survival reveals that seemingly related single gene defects have different effects on epithelial differentiation and smooth muscle and enteric nervous system development. ..
  2. Wallace K, Dolan A, Seiler C, Smith E, Yusuff S, Chaille Arnold L, et al. Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Dev Cell. 2005;8:717-26 pubmed
    ..Positional cloning identified zebrafish smooth muscle myosin heavy chain (myh11) as the responsible gene...
  3. Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, et al. Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A. 2008;105:5513-8 pubmed publisher
    ..a recessive ATPase activating germ-line mutation in smooth-muscle myosin (smmhc/myh11) underlying the zebrafish meltdown (mlt) phenotype...
  4. Davuluri G, Seiler C, Abrams J, Soriano A, Pack M. Differential effects of thin and thick filament disruption on zebrafish smooth muscle regulatory proteins. Neurogastroenterol Motil. 2010;22:1100-e285 pubmed publisher wild type zebrafish larvae following antisense knockdown of smooth muscle actin (Acta2) and myosin heavy chain (Myh11) proteins, and in colourless mutants that lack enteric nerves...
  5. Seiler C, Davuluri G, Abrams J, Byfield F, Janmey P, Pack M. Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biol. 2012;10:e1001386 pubmed publisher
    ..Here we show that epithelial cell invasion in the intestine of zebrafish meltdown (mlt) mutants arises in response to unregulated contractile tone in the surrounding smooth muscle cell layer...
  6. Pack M, Solnica Krezel L, Malicki J, Neuhauss S, Schier A, Stemple D, et al. Mutations affecting development of zebrafish digestive organs. Development. 1996;123:321-8 pubmed
    ..These gastrointestinal mutations may be informative with regard to patterning and crucial lineage decisions during organogenesis, and may be relevant to diabetes, congenital dysmorphogenesis and disorders of cell proliferation. ..
  7. Long Y, Li Q, Cui Z. Molecular analysis and heavy metal detoxification of ABCC1/MRP1 in zebrafish. Mol Biol Rep. 2011;38:1703-11 pubmed publisher
    ..These data indicate that zebrafish ABCC1 has crucial roles in heavy metals detoxification. ..
  8. Abrams J, Davuluri G, Seiler C, Pack M. Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine. Neurogastroenterol Motil. 2012;24:288-99 pubmed publisher
  9. Davis J, Long X, Georger M, Scott I, Rich A, Miano J. Expression and comparative genomics of two serum response factor genes in zebrafish. Int J Dev Biol. 2008;52:389-96 pubmed publisher

More Information


  1. Reichenbach B, Delalande J, Kolmogorova E, Prier A, Nguyen T, Smith C, et al. Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Dev Biol. 2008;318:52-64 pubmed publisher
    ..Furthermore we show that endoderm and HH signaling, but not hand2, regulate gdnf expression in the intestine, highlighting a central role of endoderm and SHH in patterning the intestine and the ENS. ..
  2. Olden T, Akhtar T, Beckman S, Wallace K. Differentiation of the zebrafish enteric nervous system and intestinal smooth muscle. Genesis. 2008;46:484-98 pubmed publisher
    ..Numbers of enteric neurons increase gradually except during periods of circular and longitudinal intestinal smooth muscle differentiation. ..
  3. Yin J, Liang Y, Park J, Chen D, Yao X, Xiao Q, et al. Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev. 2012;26:2192-205 pubmed publisher
  4. Abrams J, Einhorn Z, Seiler C, Zong A, Sweeney H, Pack M. Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish. Dis Model Mech. 2016;9:529-40 pubmed publisher
    ..We previously reported a recessive missense mutation, meltdown (mlt), which converts a highly conserved tryptophan to arginine (W512R) in the rigid relay loop of zebrafish ..
  5. Gays D, Hess C, Camporeale A, Ala U, Provero P, Mosimann C, et al. An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development. 2017;144:464-478 pubmed publisher
    ..Together, our data uncover a cascade of molecular events that govern distinct morphogenetic steps during the emergence and differentiation of vertebrate iSMCs. ..
  6. White R, Collins J, Sealy I, Wali N, Dooley C, Digby Z, et al. A high-resolution mRNA expression time course of embryonic development in zebrafish. elife. 2017;6: pubmed publisher
    ..To make this dataset a useful baseline reference, the data can be browsed and downloaded at Expression Atlas and Ensembl. ..