Genomes and Genes
Gene Symbol: myh11a
Description: myosin, heavy chain 11a, smooth muscle
Alias: myh11, myosin-11, meltdown, mlt, myosin, heavy polypeptide 11, smooth muscle a, smmhc, smooth muscle myosin heavy chain
- Reichenbach B, Delalande J, Kolmogorova E, Prier A, Nguyen T, Smith C, et al. Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Dev Biol. 2008;318:52-64 pubmed publisher..Furthermore we show that endoderm and HH signaling, but not hand2, regulate gdnf expression in the intestine, highlighting a central role of endoderm and SHH in patterning the intestine and the ENS. ..
- Olden T, Akhtar T, Beckman S, Wallace K. Differentiation of the zebrafish enteric nervous system and intestinal smooth muscle. Genesis. 2008;46:484-98 pubmed publisher..Numbers of enteric neurons increase gradually except during periods of circular and longitudinal intestinal smooth muscle differentiation. ..
- Abrams J, Einhorn Z, Seiler C, Zong A, Sweeney H, Pack M. Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish. Dis Model Mech. 2016;9:529-40 pubmed publisher..We previously reported a recessive missense mutation, meltdown (mlt), which converts a highly conserved tryptophan to arginine (W512R) in the rigid relay loop of zebrafish ..
- Gays D, Hess C, Camporeale A, Ala U, Provero P, Mosimann C, et al. An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development. 2017;144:464-478 pubmed publisher..Together, our data uncover a cascade of molecular events that govern distinct morphogenetic steps during the emergence and differentiation of vertebrate iSMCs. ..
- White R, Collins J, Sealy I, Wali N, Dooley C, Digby Z, et al. A high-resolution mRNA expression time course of embryonic development in zebrafish. elife. 2017;6: pubmed publisher..To make this dataset a useful baseline reference, the data can be browsed and downloaded at Expression Atlas and Ensembl. ..