myf6

Summary

Gene Symbol: myf6
Description: myogenic factor 6
Alias: herculin, mrf4, myogenic factor 6, muscle-specific regulatory factor 4, myf-6
Species: zebrafish
Products:     myf6

Top Publications

  1. Lee C, Hu S, Gong H, Chen M, Lu J, Wu J. Suppression of myostatin with vector-based RNA interference causes a double-muscle effect in transgenic zebrafish. Biochem Biophys Res Commun. 2009;387:766-71 pubmed publisher
    ..Also, the mRNA levels of myogenic regulatory factor markers such as MyoD, myogenin, Mrf4, and Myf5 were dramatically elevated in myostatin-suppressed transgenic fish compared to the non-transgenic ..
  2. Lin C, Yung R, Lee H, Chen W, Chen Y, Tsai H. Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish. Dev Biol. 2006;299:594-608 pubmed
    ..On the basis of the expression patterns of myf5 and myod, we propose a model to present how Myf5 and Myod are involved in head myogenesis of zebrafish. ..
  3. Ignatius M, Chen E, Elpek N, Fuller A, Tenente I, Clagg R, et al. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer Cell. 2012;21:680-93 pubmed publisher
    ..Our data suggest that non-tumor-propagating cells likely have important supportive roles in cancer progression and facilitate metastasis. ..
  4. Liang X, Souders C, Zhang J, Martyniuk C. Tributyltin induces premature hatching and reduces locomotor activity in zebrafish (Danio rerio) embryos/larvae at environmentally relevant levels. Chemosphere. 2017;189:498-506 pubmed publisher
    ..mechanisms related to changes in behavioral activity, we measured transcripts associated with muscle function (myf6, myoD, and myoG) and dopamine signaling (th, dat, dopamine receptors) as dopamine regulates behavior...
  5. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, et al. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Front Endocrinol (Lausanne). 2016;7:88 pubmed publisher
    ..Our mstnb-deficient model could be valuable in understanding not only the growth trait regulation in teleosts but also the mechanisms of teleost energy metabolism. ..
  6. Maragh S, Miller R, Bessling S, Wang G, Hook P, McCallion A. Rbm24a and Rbm24b are required for normal somitogenesis. PLoS ONE. 2014;9:e105460 pubmed publisher
  7. Li Y, Chen H, Li Y, Wu S, Wangta Liu -, Lin G, et al. Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells. Sci Rep. 2013;3:1176 pubmed publisher
    ..In conclusion, we demonstrate a critical role for PGRN in the maintenance of MPC and suggest that muscle atrophy under PGRN loss may begin with MPC during postembryonic myogenesis. ..
  8. Veldman M, Zhao C, Gomez G, Lindgren A, Huang H, Yang H, et al. Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor Etv2. PLoS Biol. 2013;11:e1001590 pubmed publisher
    ..Given the evolutionarily conserved function of this transcription factor and the responsiveness of mammalian myoblasts to Etv2, it is likely that mammalian muscle cells will respond similarly. ..
  9. Wang Y, Li C, Lee G, Tsay H, Tsai H, Chen Y. Inactivation of zebrafish mrf4 leads to myofibril misalignment and motor axon growth disorganization. Dev Dyn. 2008;237:1043-50 pubmed publisher
    b>Mrf4 is a basic helix-loop-helix (bHLH) transcription factor associated with myogenesis. Two mrf4 transcripts, mrf4_tv1 and mrf4_tv2, were identified in zebrafish generated by alternative splicing...

More Information

Publications20

  1. Maak S, Neumann K, Swalve H. Identification and analysis of putative regulatory sequences for the MYF5/MYF6 locus in different vertebrate species. Gene. 2006;379:141-7 pubmed
    ..We performed a comparative sequence analysis of the MYF5/MYF6 locus in swine, cattle, dog, chicken and zebrafish on the basis of structural and functional information from human ..
  2. Housley M, Reischauer S, Dieu M, Raes M, Stainier D, Vanhollebeke B. Translational profiling through biotinylation of tagged ribosomes in zebrafish. Development. 2014;141:3988-93 pubmed publisher
    ..Through this work we have thus developed additional tools for highly specific gene expression profiling. ..
  3. Gurevich D, Nguyen P, Siegel A, Ehrlich O, Sonntag C, Phan J, et al. Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo. Science. 2016;353:aad9969 pubmed publisher
  4. Amaral I, Johnston I. Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish. Am J Physiol Regul Integr Comp Physiol. 2012;302:R193-206 pubmed publisher
    ..7-fold for the repressor per1a. Out of 32 candidate clock-controlled genes, only myf6, igfbp3, igfbp5b, and hsf2 showed circadian expression patterns...
  5. Delgado Olguin P, Brand Arzamendi K, Scott I, Jungblut B, Stainier D, Bruneau B, et al. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011;286:12483-94 pubmed publisher
    ..We conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis. ..
  6. Schnapp E, Pistocchi A, Karampetsou E, Foglia E, Lamia C, Cotelli F, et al. Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo. J Cell Sci. 2009;122:481-8 pubmed publisher
    ..but their role has been studied in great detail only in the mouse embryo, where all but myogenin--Myod, Myf5 and Mrf4--are sufficient to activate (albeit not completely) skeletal myogenesis...
  7. Ulloa P, Peña A, Lizama C, Araneda C, Iturra P, Neira R, et al. Growth response and expression of muscle growth-related candidate genes in adult zebrafish fed plant and fishmeal protein-based diets. Zebrafish. 2013;10:99-109 pubmed publisher
    ..At 98?dpf, growth-related genes Igf1a, Igf2a, mTOR, Pld1a, Mrf4, Myod, Myogenin, and Myostatin1b were evaluated...
  8. Osborn D, Li K, Hinits Y, Hughes S. Cdkn1c drives muscle differentiation through a positive feedback loop with Myod. Dev Biol. 2011;350:464-75 pubmed publisher
    ..Cdkn1c co-operates with Myod to drive differentiation of several early zebrafish muscle fibre types. Myod in turn up-regulates cdkn1c, thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation. ..
  9. Hinits Y, Osborn D, Carvajal J, Rigby P, Hughes S. Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle. Gene Expr Patterns. 2007;7:738-45 pubmed
    Mrf4 (Myf6) is a member of the basic helix-loop-helix (bHLH) myogenic regulatory transcription factor (MRF) family, which also contains Myod, Myf5 and myogenin...
  10. Zhang J, Laurence Souders C, Denslow N, Martyniuk C. Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). Toxicol Appl Pharmacol. 2017;327:30-38 pubmed publisher
    ..Our data support the hypothesis that quercetin may affect locomotion and induce deformities in zebrafish larvae by diminishing ATP production and by altering the expression of transcripts related to muscle formation and activity. ..
  11. Hinits Y, Osborn D, Hughes S. Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations. Development. 2009;136:403-14 pubmed publisher
    ..However, the roles of each gene in myogenesis remain unclear, owing partly to genetic linkage at the Myf5/Mrf4 locus and to rapid morphogenetic movements in the amniote somite...