Gene Symbol: mybl2b
Description: v-myb avian myeloblastosis viral oncogene homolog-like 2b
Alias: mybl2, myb-related protein B, MOL2, b-myb, crash&burn, crb, myeloblastosis oncogene-like 2, v-myb avian myeloblastosis viral oncogene homolog-like 2
Species: zebrafish
Products:     mybl2b

Top Publications

  1. Shepard J, Amatruda J, Stern H, Subramanian A, Finkelstein D, Ziai J, et al. A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A. 2005;102:13194-9 pubmed
    ..forward genetic screen uncovered multiple cell proliferation mutants including one mutant, crash&burn (crb), that represents a loss-of-function mutation in bmyb, a transcriptional regulator and member of a putative proto-..
  2. Stern H, Murphey R, Shepard J, Amatruda J, Straub C, Pfaff K, et al. Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol. 2005;1:366-70 pubmed
    ..Loss of bmyb function in the zebrafish mutant crash&burn (crb) results in decreased cyclin B1 expression, mitotic arrest and genome instability...
  3. Kleinschmidt M, Wagner T, Liedtke D, Spahr S, Samans B, Gaubatz S. lin9 is required for mitosis and cell survival during early zebrafish development. J Biol Chem. 2009;284:13119-27 pubmed publisher
    ..Our data establish LIN9 as an essential regulator of mitosis in vertebrate development. ..
  4. Sucularli C, Senturk S, Ozturk M, Konu O. Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment. Mol Biol Rep. 2011;38:4111-23 pubmed publisher identify several targets of E2F transcription factors that are known to be serum-responsive; namely, PCNA, MYBL2, MCM7, TYMS, and CTGF...
  5. Chiarelli N, Ritelli M, Zoppi N, Benini A, Borsani G, Barlati S, et al. Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. Int J Dev Biol. 2011;55:229-36 pubmed publisher
    ..In later embryonic stages, slc2a10 mRNA was detected in the otic vesicles, hatching gland cells, pectoral fin, posterior tectum and swim bladder. Overall, these results suggest a wide role of slc2a10 during zebrafish development. ..
  6. Zon L, Peterson R. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005;4:35-44 pubmed
  7. Chen J, Carney S, Peterson R, Heideman W. Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart. Physiol Genomics. 2008;33:148-58 pubmed publisher
    ..Among the genes rapidly induced by RA was Nr2F5, a member of the COUP-TF family of transcriptional repressors. We found that induction of Nr2F5 was both necessary and sufficient for the cardiotoxic response to RA. ..