Gene Symbol: mxe
Description: myxovirus (influenza virus) resistance E
Alias: wu:fj93f01, zgc:111895, interferon-induced GTP-binding protein MxE, IFN-inducible antiviral protein MxE, interferon-inducible MxE protein
Lutfalla G, Roest Crollius H, Stange Thomann N, Jaillon O, Mogensen K, Monneron D. Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: the class II cytokine receptors and their ligands in mammals and fish. BMC Genomics. 2003;4:29 pubmed
..Despite the report of a near complete pufferfish (Takifugu rubripes) genome sequence, these genes remain undescribed in fish...
Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang Z, et al
. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol. 2010;29:399-406 pubmed publisher
..This study shows the protective effects of interferon against a DNA-virus in fish for the first time and provides information about the efficacy of fish interferon that will prove useful in possible therapeutic applications. ..
Huang B, Huang W, Nie P. Characterization of four Mx isoforms in the European eel, Anguilla anguilla. Fish Shellfish Immunol. 2013;35:1048-54 pubmed publisher
..These four isoforms of eel Mx are thus expressed differentially, and further work is certainly required to clarify the activity of promoter elements and antiviral activity of these Mx isoforms. ..
Chen H, Liu W, Wu S, Chiou P, Li Y, Chen Y, et al
. RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish Shellfish Immunol. 2015;43:427-35 pubmed publisher
..Taken together, our results indicate that RIG-I plays an essential role in zebrafish group II type I IFN induction and the inflammatory response to NNV infection. ..
Estepa A, Coll J. Innate Multigene Family Memories Are Implicated in the Viral-Survivor Zebrafish Phenotype. PLoS ONE. 2015;10:e0135483 pubmed publisher
..The implications of the so-called "trained immunity" for future research in this field are also discussed. ..
Zhang L, Chen W, Hu Y, Wu X, Nie P, Chang M. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish Shellfish Immunol. 2016;54:135-43 pubmed publisher
..Collectively, these data support that zebrafish TBK1L negatively regulates RLRs-MAVS-TBK1 pathway. ..