mtx2

Summary

Gene Symbol: mtx2
Description: metaxin 2
Alias: wu:fc02d09, metaxin-2, fc02d09
Species: zebrafish

Top Publications

  1. Adolph K. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. Gene. 2004;330:67-73 pubmed
    ..The zebrafish metaxin genes are designated mtx1, mtx2 and mtx3, following zebrafish nomenclature guidelines...
  2. Zhang T, Yao S, Wang P, Yin C, Xiao C, Qian M, et al. ApoA-II directs morphogenetic movements of zebrafish embryo by preventing chromosome fusion during nuclear division in yolk syncytial layer. J Biol Chem. 2011;286:9514-25 pubmed publisher
  3. Bruce A, Howley C, Dixon Fox M, Ho R. T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish. Dev Dyn. 2005;233:105-14 pubmed
    ..We also show that eomes regulates the expression of a zygotic homeobox transcription factor mtx2. Gene knockdown of mtx2 using antisense morpholino oligonucleotides, likewise, leads to an inhibition of epiboly; ..
  4. Muto A, Arai K, Watanabe S. Rab11-FIP4 is predominantly expressed in neural tissues and involved in proliferation as well as in differentiation during zebrafish retinal development. Dev Biol. 2006;292:90-102 pubmed
  5. Mackay E, Apschner A, Schulte Merker S. Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI. Development. 2015;142:1095-101 pubmed publisher
    ..Additionally, we found that abcc6a is strongly expressed at the site of mineralisation rather than the liver, as it is in mammals, which has significant implications for our understanding of the function of ABCC6. ..
  6. Woltering J, Durston A. The zebrafish hoxDb cluster has been reduced to a single microRNA. Nat Genet. 2006;38:601-2 pubmed
  7. Wilkins S, Yoong S, Verkade H, Mizoguchi T, Plowman S, Hancock J, et al. Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation. Dev Biol. 2008;314:12-22 pubmed
    The homeobox transcription factor Mtx2 is essential for epiboly, the first morphogenetic movement of gastrulation in zebrafish. Morpholino knockdown of Mtx2 results in stalling of epiboly and lysis due to yolk rupture...