Gene Symbol: mttp
Description: microsomal triglyceride transfer protein
Alias: mtp, wu:fd36b01, zgc:111876, microsomal triglyceride transfer protein large subunit, stalactite, stl
Species: zebrafish

Top Publications

  1. Schlegel A, Stainier D. Microsomal triglyceride transfer protein is required for yolk lipid utilization and absorption of dietary lipids in zebrafish larvae. Biochemistry. 2006;45:15179-87 pubmed
    ..Levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging TAG and betalipoproteins into lipoprotein particles, were unchanged by ..
  2. Avraham Davidi I, Ely Y, Pham V, Castranova D, Grunspan M, Malkinson G, et al. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med. 2012;18:967-73 pubmed publisher
    ..Using a genetic screen for vascular defects in zebrafish, we initially identified a mutation, stalactite (stl), in the gene encoding microsomal triglyceride transfer protein (mtp), which is involved in the ..
  3. Marza E, Barthe C, André M, Villeneuve L, Hélou C, Babin P. Developmental expression and nutritional regulation of a zebrafish gene homologous to mammalian microsomal triglyceride transfer protein large subunit. Dev Dyn. 2005;232:506-18 pubmed
    The microsomal triglyceride transfer protein (MTP) large subunit is required for the assembly and secretion of apolipoprotein B-containing lipoproteins...
  4. Babin P. Conservation of a vitellogenin gene cluster in oviparous vertebrates and identification of its traces in the platypus genome. Gene. 2008;413:76-82 pubmed publisher
    ..Genomic identification of Vtgs, Apob, and Mtp in this genome, together with maximum likelihood and Bayesian inference phylogenetic analyses, support the ..
  5. Passeri M, Cinaroglu A, Gao C, Sadler K. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology. 2009;49:443-52 pubmed publisher
    ..Srebp activation is required for steatosis in this model. The tractability of zebrafish genetics provides a valuable tool for dissecting the molecular pathogenesis of acute ALD. ..
  6. Lim A, Suli A, Yaniv K, Weinstein B, Li D, Chien C. Motoneurons are essential for vascular pathfinding. Development. 2011;138:3847-57 pubmed publisher
    ..These results provide a definitive example of the requirement of axons in endothelial guidance leading to the parallel patterning of nerves and vessels in vivo. ..
  7. Liu C, Gaudet D, Miller Y. Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. PLoS ONE. 2017;12:e0169939 pubmed publisher
    ..In summary, this study, using a zebrafish model and human patient samples, reports for the first time the defect in plasma cholesterol esterification associated with LPL deficiency. ..
  8. Caro M, Sansone A, Amezaga J, Navarro V, Ferreri C, Tueros I. Wine lees modulate lipid metabolism and induce fatty acid remodelling in zebrafish. Food Funct. 2017;8:1652-1659 pubmed publisher
    ..On the whole, wine lees polyphenolic extract was effective at modulating zebrafish lipid metabolism evidencing remodelling effects and antioxidant properties that can be further developed for food innovation. ..
  9. Meguro S, Hasumura T, Hase T. Coffee polyphenols exert hypocholesterolemic effects in zebrafish fed a high-cholesterol diet. Nutr Metab (Lond). 2013;10:61 pubmed publisher
    ..3-hydroxy-3-methylglutaryl-coenzyme A reductase A, a rate-limiting enzyme in cholesterol biosynthesis) and mtp (encoding microsomal triglyceride transfer protein, a lipid transfer protein required for assembly and secretion of ..

More Information


  1. Tingaud Sequeira A, Knoll Gellida A, André M, Babin P. Vitellogenin expression in white adipose tissue in female teleost fish. Biol Reprod. 2012;86:38 pubmed publisher
    ..It was also found to coexpress mtp, known to perform the intracellular lipidation of Vtg prior to secretion...
  2. Karanth S, Tran V, Kuberan B, Schlegel A. Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Dis Model Mech. 2013;6:1365-77 pubmed publisher
    ..These results elucidate a mechanism for PUFA-mediated cholesterol lowering through direct inhibition of Hmgcr. ..
  3. Miyares R, de Rezende V, Farber S. Zebrafish yolk lipid processing: a tractable tool for the study of vertebrate lipid transport and metabolism. Dis Model Mech. 2014;7:915-27 pubmed publisher
    ..Furthermore, we examine the metabolic fate of exogenously delivered fatty acids by assaying their incorporation into complex lipids. Moreover, we demonstrate that this technique is amenable to genetic and pharmacologic studies. ..
  4. Cruz Garcia L, Schlegel A. Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids. J Lipid Res. 2014;55:1944-58 pubmed publisher
    ..Activation of Lxr in the intestine cell-autonomously regulates the rate of delivery of absorbed lipids by inducting a temporary lipid intestinal droplet storage depot. ..
  5. Zeituni E, Wilson M, Zheng X, Iglesias P, Sepanski M, Siddiqi M, et al. Endoplasmic Reticulum Lipid Flux Influences Enterocyte Nuclear Morphology and Lipid-dependent Transcriptional Responses. J Biol Chem. 2016;291:23804-23816 pubmed
    ..Using a microsomal triglyceride transfer protein (MTP) inhibitor to block ?-lipoprotein particle formation, we demonstrate that the transcriptional response to a high-..
  6. Ghajar C, Peinado H, Mori H, Matei I, Evason K, Brazier H, et al. The perivascular niche regulates breast tumour dormancy. Nat Cell Biol. 2013;15:807-17 pubmed publisher
    ..Our work reveals that stable microvasculature constitutes a dormant niche, whereas sprouting neovasculature sparks micrometastatic outgrowth...
  7. Baker B, Yee J, Meyer D, Yang D, Baker T. Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Zebrafish. 2016;13:413-23 pubmed publisher
    ..These data will inform future investigations to elucidate the mechanism of adult-onset and transgenerational infertility due to TCDD exposure in zebrafish. ..
  8. Raldua D, André M, Babin P. Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish. Toxicol Appl Pharmacol. 2008;228:301-14 pubmed publisher
    ..acox1, apoa1 and mtp hybridization transcript signals were not affected in the yolk syncytial layer (YSL) after clofibrate exposure...