Gene Symbol: msx2b
Description: muscle segment homeobox 2b
Alias: msh-D, mshD, msxd, homeobox protein MSH-D, muscle segment homeobox D
Species: zebrafish

Top Publications

  1. Akimenko M, Johnson S, Westerfield M, Ekker M. Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish. Development. 1995;121:347-57 pubmed
    ..fin development and regeneration, we have analysed the expression of four homeobox genes, msxA, msxB, msxC and msxD in zebrafish fins...
  2. Postlethwait J. The zebrafish genome: a review and msx gene case study. Genome Dyn. 2006;2:183-97 pubmed publisher
    ..and evolution of duplicate gene function are discussed here using as a case study the zebrafish msxa, msxb, msxc, msxd, and msxe genes, which together constitute zebrafish orthologs of tetrapod Msx1, Msx2, and Msx3...
  3. Kague E, Roy P, Asselin G, Hu G, Simonet J, Stanley A, et al. Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol. 2016;413:160-72 pubmed publisher
    ..The delay in bone maturation caused by loss of Sp7 leads to unregulated bone formation, revealing a new mechanism for patterning the skull and sutures. ..
  4. Ekker M, Akimenko M, Allende M, Smith R, Drouin G, Langille R, et al. Relationships among msx gene structure and function in zebrafish and other vertebrates. Mol Biol Evol. 1997;14:1008-22 pubmed
    The zebrafish genome contains at least five msx homeobox genes, msxA, msxB, msxC, msxD, and the newly isolated msxE...
  5. Murciano C, PĂ©rez Claros J, Smith A, Avaron F, Fernandez T, Duran I, et al. Position dependence of hemiray morphogenesis during tail fin regeneration in Danio rerio. Dev Biol. 2007;312:272-83 pubmed
    ..A morphological study of the developing and regenerating fin of another long fin mutant zebrafish suggests that contralateral hemiblastema interactions are perturbed in this mutant. ..
  6. Van Hellemont R, Blomme T, Van de Peer Y, Marchal K. Divergence of regulatory sequences in duplicated fish genes. Genome Dyn. 2007;3:81-100 pubmed publisher
    ..In this study we used in silico motif detection to show how alterations in the composition of regulatory motifs between paralogous genes in zebrafish and Tetraodon might reflect the functional divergence of duplicates. ..
  7. Camarata T, Snyder D, Schwend T, Klosowiak J, Holtrup B, Simon H. Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development. BMC Dev Biol. 2010;10:104 pubmed publisher
    ..These new regulatory mechanisms may have important implications how we interpret Tbx5 function in congenital hand/heart syndromes in humans. ..
  8. Ekker M, Speevak M, Martin C, Joly L, Giroux G, Chevrette M. Stable transfer of zebrafish chromosome segments into mouse cells. Genomics. 1996;33:57-64 pubmed
    ..Zebrafish/mouse cell hybrids will provide a useful tool for the physical mapping of the zebrafish genome and for the cloning of genes affected in zebrafish mutants. ..
  9. Riley B, Grunwald D. A mutation in zebrafish affecting a localized cellular function required for normal ear development. Dev Biol. 1996;179:427-35 pubmed
    ..Expression patterns of several ear marker genes (msxC, msxD, and dlx3) also appear normal in the mutant...

More Information


  1. Fritz A, Rozowski M, Walker C, Westerfield M. Identification of selected gamma-ray induced deficiencies in zebrafish using multiplex polymerase chain reaction. Genetics. 1996;144:1735-45 pubmed
    ..These deficiencies provide a basis for analyzing the functions of cloned zebrafish genes using noncomplementation screens for point mutations induced by high-efficiency chemical mutagenesis. ..
  2. Connors S, Trout J, Ekker M, Mullins M. The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo. Development. 1999;126:3119-30 pubmed
    ..This extracellular mechanism is amplified by an autoregulatory loop for bmp gene expression. ..
  3. Smith A, Zhang J, Guay D, Quint E, Johnson A, Akimenko M. Gene expression analysis on sections of zebrafish regenerating fins reveals limitations in the whole-mount in situ hybridization method. Dev Dyn. 2008;237:417-25 pubmed publisher
  4. Sarras M, Leontovich A, Olsen A, Intine R. Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish. Wound Repair Regen. 2013;21:320-8 pubmed publisher
    ..The aberrant expression of key regulatory genes in the DM state that persist into the MM state provides a plausible explanation on how hyperglycemia induced impaired fin regeneration in the adult zebrafish DM/MM model. ..