Gene Symbol: msx2a
Description: muscle segment homeobox 2a
Alias: msh-A, mshA, msxa, zgc:111929, homeobox protein MSH-A, etID309845.14, muscle segment homeobox A
Species: zebrafish

Top Publications

  1. Fritz A, Rozowski M, Walker C, Westerfield M. Identification of selected gamma-ray induced deficiencies in zebrafish using multiplex polymerase chain reaction. Genetics. 1996;144:1735-45 pubmed
    ..These deficiencies provide a basis for analyzing the functions of cloned zebrafish genes using noncomplementation screens for point mutations induced by high-efficiency chemical mutagenesis. ..
  2. Van Hellemont R, Blomme T, Van de Peer Y, Marchal K. Divergence of regulatory sequences in duplicated fish genes. Genome Dyn. 2007;3:81-100 pubmed publisher
    ..In this study we used in silico motif detection to show how alterations in the composition of regulatory motifs between paralogous genes in zebrafish and Tetraodon might reflect the functional divergence of duplicates. ..
  3. Holland P. Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. Gene. 1991;98:253-7 pubmed
    ..intestinalis and D. melanogaster. Sequence analyses suggest that multiple msh gene duplications occurred in the lineage leading to vertebrates, after the divergence of the ascidia. ..
  4. Postlethwait J, Yan Y, Gates M, Horne S, Amores A, Brownlie A, et al. Vertebrate genome evolution and the zebrafish gene map. Nat Genet. 1998;18:345-9 pubmed
    ..This zebrafish gene map will facilitate molecular identification of mutated zebrafish genes, which can suggest functions for human genes known only by sequence. ..
  5. Murciano C, Fernandez T, Duran I, Maseda D, Ruiz Sanchez J, Becerra J, et al. Ray-interray interactions during fin regeneration of Danio rerio. Dev Biol. 2002;252:214-24 pubmed
    ..In addition, gene expression analysis under these experimental conditions suggests that msxA and msxD expression in the ray and interray epidermis is controlled by the ray blastema and that bmp4 could be a ..
  6. Garcia Valtanen P, Ortega Villaizan M, Martínez López A, Medina Gali R, Perez L, MacKenzie S, et al. Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. Autophagy. 2014;10:1666-80 pubmed publisher
    ..Altogether these results suggest that strategies aimed at modulating autophagy could be used for the prevention and treatment of rhabdoviral infections such as rabies, which causes thousands of human deaths every year. ..
  7. Akimenko M, Johnson S, Westerfield M, Ekker M. Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish. Development. 1995;121:347-57 pubmed
    ..pattern formation during fin development and regeneration, we have analysed the expression of four homeobox genes, msxA, msxB, msxC and msxD in zebrafish fins...
  8. Ekker M, Akimenko M, Allende M, Smith R, Drouin G, Langille R, et al. Relationships among msx gene structure and function in zebrafish and other vertebrates. Mol Biol Evol. 1997;14:1008-22 pubmed
    The zebrafish genome contains at least five msx homeobox genes, msxA, msxB, msxC, msxD, and the newly isolated msxE...
  9. Postlethwait J. The zebrafish genome: a review and msx gene case study. Genome Dyn. 2006;2:183-97 pubmed publisher
    ..genome duplication, and evolution of duplicate gene function are discussed here using as a case study the zebrafish msxa, msxb, msxc, msxd, and msxe genes, which together constitute zebrafish orthologs of tetrapod Msx1, Msx2, and Msx3...

More Information


  1. Harris M, Rohner N, Schwarz H, Perathoner S, Konstantinidis P, NUSSLEIN VOLHARD C. Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. PLoS Genet. 2008;4:e1000206 pubmed publisher
    ..Lastly, our findings point to the utility of adult genetic screens in the zebrafish in identifying essential developmental processes involved in human disease and in morphological evolution. ..