Gene Symbol: mstna
Description: myostatin a
Alias: gdf8l, mstn-2, mstn2, si:dkeyp-84a8.5, myostatin a, cytokine/differentiation factor, growth differentiation factor 8, like, inhibitor of skeletal muscle growth and development, myostatin II, myostatin form 2
Species: zebrafish

Top Publications

  1. Lee C, Hu S, Gong H, Chen M, Lu J, Wu J. Suppression of myostatin with vector-based RNA interference causes a double-muscle effect in transgenic zebrafish. Biochem Biophys Res Commun. 2009;387:766-71 pubmed publisher
    ..This is the first model zebrafish with a hereditarily stable myostatin-suppressed genotype and a double-muscle phenotype. ..
  2. Biga P, Roberts S, Iliev D, McCauley L, Moon J, Collodi P, et al. The isolation, characterization, and expression of a novel GDF11 gene and a second myostatin form in zebrafish, Danio rerio. Comp Biochem Physiol B Biochem Mol Biol. 2005;141:218-30 pubmed
    ..This study also cloned a second MSTN form in zebrafish most similar to Salmonid MSTN2 forms...
  3. Meyer B, Froehlich J, Galt N, Biga P. Inbred strains of zebrafish exhibit variation in growth performance and myostatin expression following fasting. Comp Biochem Physiol A Mol Integr Physiol. 2013;164:1-9 pubmed publisher
    ..These data can help future research endeavors by highlighting the attributes of each strain with regard to growth performance so that the most fitting strain may be utilized. ..
  4. Zucchi S, Castiglioni S, Fent K. Progesterone alters global transcription profiles at environmental concentrations in brain and ovary of female zebrafish (Danio rerio). Environ Sci Technol. 2013;47:12548-56 pubmed publisher
    ..The data show molecular effects and the modes of action of P4 at environmental concentrations. Ultimately they may translate to adverse effects on reproduction. ..
  5. Xie S, Bian W, Wang C, Junaid M, Zou J, Pei D. A novel technique based on in vitro oocyte injection to improve CRISPR/Cas9 gene editing in zebrafish. Sci Rep. 2016;6:34555 pubmed publisher
    ..Due to high throughputs, simplicity and flexible design, this novel strategy will provide an efficient alternative to increase the speed of generating heritable mutants in zebrafish by using CRISPR/Cas9 system. ..
  6. Sundarrajan L, Yeung C, Hahn L, Weber L, Unniappan S. Irisin regulates cardiac physiology in zebrafish. PLoS ONE. 2017;12:e0181461 pubmed publisher
    ..In vitro studies found that treatment with irisin (0.1 nM) downregulated the expression of PGC-1 alpha, myostatin a, and b, while upregulating troponin C mRNA expression in zebrafish heart and skeletal muscle...
  7. Wang C, Chen Y, Bian W, Xie S, Qi G, Liu L, et al. Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish Shellfish Immunol. 2018;72:572-580 pubmed publisher
    ..In this study, mstna-/- and mstnb-/- homozygous zebrafish were firstly generated using CRISPR/Cas9 (Clustered ..
  8. Kerr T, Roalson E, Rodgers B. Phylogenetic analysis of the myostatin gene sub-family and the differential expression of a novel member in zebrafish. Evol Dev. 2005;7:390-400 pubmed
    ..These data suggest that zfMSTN-2 may be more closely associated with skeletal muscle growth and development. They also resolve the previous ambiguity in classification of fish MSTN genes. ..
  9. Helterline D, Garikipati D, Stenkamp D, Rodgers B. Embryonic and tissue-specific regulation of myostatin-1 and -2 gene expression in zebrafish. Gen Comp Endocrinol. 2007;151:90-7 pubmed
    ..The increased expression of both genes in spleens from stressed fish is further supportive of an immunomodulatory role and may explain increased disease susceptibility associated with stocking stress. ..

More Information


  1. Amali A, Lin C, Chen Y, Wang W, Gong H, Rekha R, et al. Overexpression of Myostatin2 in zebrafish reduces the expression of dystrophin associated protein complex (DAPC) which leads to muscle dystrophy. J Biomed Sci. 2008;15:595-604 pubmed publisher
    ..In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cDNA is 1342 bp with 109 and 132 bp of 5' and 3'-untranslated regions (UTRs), respectively...
  2. Nadjar Boger E, Funkenstein B. Myostatin-2 gene structure and polymorphism of the promoter and first intron in the marine fish Sparus aurata: evidence for DNA duplications and/or translocations. BMC Genet. 2011;12:22 pubmed publisher
    ..These results show for the first time a substantial degree of polymorphism in both the promoter and first intron of MSTN-2 gene in a perciform fish species which points to chromosomal rearrangements that took place during evolution. ..
  3. Nadjar Boger E, Hinits Y, Funkenstein B. Structural and functional analysis of myostatin-2 promoter alleles from the marine fish Sparus aurata: evidence for strong muscle-specific promoter activity and post-transcriptional regulation. Mol Cell Endocrinol. 2012;361:51-68 pubmed publisher
    ..In conclusion, our study shows for the first time that MSTN-2 promoter is a very robust promoter, especially in muscle cells. ..
  4. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, et al. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Front Endocrinol (Lausanne). 2016;7:88 pubmed publisher
    ..Our mstnb-deficient model could be valuable in understanding not only the growth trait regulation in teleosts but also the mechanisms of teleost energy metabolism. ..
  5. Zhang J, Laurence Souders C, Denslow N, Martyniuk C. Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). Toxicol Appl Pharmacol. 2017;327:30-38 pubmed publisher
    ..The expression levels of both myostatin A (mstna) and myogenic differentiation (myoD) were also altered by quercetin...