Gene Symbol: mpv17
Description: MpV17 mitochondrial inner membrane protein
Alias: roy, zgc:63573, protein Mpv17, MpV17 transgene, murine homolog, glomerulosclerosis, tra, transparent
Species: zebrafish

Top Publications

  1. Presslauer C, Bizuayehu T, Razmi K, Fernandes J, Babiak I. See-Thru-Gonad zebrafish line: developmental and functional validation. Reproduction. 2016;152:507-17 pubmed publisher
    ..In this study, we established See-Thru-Gonad zebrafish, a transparent line with fluorescently labeled germ cells visible throughout the life cycle, validated its gonadal development ..
  2. Krauss J, Astrinidis P, Astrinides P, Frohnhöfer H, Walderich B, NUSSLEIN VOLHARD C. transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival. Biol Open. 2013;2:703-10 pubmed publisher
    ..We describe the adult viable and fertile mutant transparent (tra), which shows a loss or strong reduction of iridophores throughout larval and adult stages...
  3. Löllgen S, Weiher H. The role of the Mpv17 protein mutations of which cause mitochondrial DNA depletion syndrome (MDDS): lessons from homologs in different species. Biol Chem. 2015;396:13-25 pubmed publisher
    ..However, the nuclear gene MPV17, whose mutated forms are associated with hepatocerebral MDDS in humans, plays a so-far unknown role in mtDNA ..
  4. Dempsey W, Georgieva L, Helbling P, Sonay A, Truong T, Haffner M, et al. In vivo single-cell labeling by confined primed conversion. Nat Methods. 2015;12:645-8 pubmed publisher
    ..With a straightforward addition to a conventional confocal microscope, we show confined primed conversion in living zebrafish and reveal the complex anatomy of individual neurons packed between neighboring cells. ..
  5. Lawrence C, James A, Mobley S. Successful Replacement of Artemia salina nauplii with Marine Rotifers (Brachionus plicatilis) in the Diet of Preadult Zebrafish (Danio rerio). Zebrafish. 2015;12:366-71 pubmed publisher
    ..While growth performance was significantly better in the RA groups, we were still able to meet goals for both weaning and generation time in the R groups without compromising survival or sex ratios. ..
  6. Wu L, Wary K, REVSKOY S, Gao X, Tsang K, Komarova Y, et al. Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells. Stem Cell Reports. 2015;5:10-21 pubmed publisher
    ..These findings together demonstrate the essential role of KDM4A and KDM4C in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 and VE-cadherin promoters, respectively. ..
  7. Li L, Ji D, Teng L, Zhang S, Li H. Identification and expression of lypc, a novel dark-inducible member of Ly6 superfamily in zebrafish Danio rerio. Gene. 2015;574:69-75 pubmed publisher
    ..Collectively, these data indicate that lypc is a novel dark-inducible Ly6 member with a predominant expression in the pigment cells of zebrafish, laying a foundation for further elucidation of its functions. ..
  8. Fernández Murray J, Prykhozhij S, Dufay J, Steele S, Gaston D, Nasrallah G, et al. Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. PLoS Genet. 2016;12:e1005783 pubmed publisher
    ..Given the tolerability of glycine and folate in humans, this study points to a potential novel treatment for SLC25A38 congenital sideroblastic anemia. ..
  9. Xie S, Bian W, Wang C, Junaid M, Zou J, Pei D. A novel technique based on in vitro oocyte injection to improve CRISPR/Cas9 gene editing in zebrafish. Sci Rep. 2016;6:34555 pubmed publisher
    ..Due to high throughputs, simplicity and flexible design, this novel strategy will provide an efficient alternative to increase the speed of generating heritable mutants in zebrafish by using CRISPR/Cas9 system. ..

More Information


  1. D Agati G, Beltre R, Sessa A, Burger A, Zhou Y, Mosimann C, et al. A defect in the mitochondrial protein Mpv17 underlies the transparent casper zebrafish. Dev Biol. 2017;430:11-17 pubmed publisher
    ..mutation is phenotypically and molecularly remarkably similar to another zebrafish iridophore mutant called transparent. Using Cas9-induced crispants and germline mutants with a disrupted mpv17 open reading frame, we show in trans-..