Gene Symbol: mpi
Description: mannose phosphate isomerase
Alias: im:7140016, zgc:110773, mannose-6-phosphate isomerase
Species: zebrafish

Top Publications

  1. Ling X, Lu Y, Huang H. Differential protein profile in zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Environ Sci Pollut Res Int. 2012;19:3925-41 pubmed publisher
    ..The results may also provide the possibility of the establishment of candidate biomarkers for monitoring MP and Cd contamination in water. ..
  2. Shtraizent N, DeRossi C, Nayar S, Sachidanandam R, Katz L, Prince A, et al. MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. elife. 2017;6: pubmed publisher
    ..We uncover a previously unappreciated role for Mannose phosphate isomerase (MPI) as a metabolic enzyme required to maintain Warburg metabolism in zebrafish embryos and in both primary and ..
  3. Sun Q, Liu X, Gong B, Wu D, Meng A, Jia S. Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. Int J Biol Sci. 2017;13:1051-1066 pubmed publisher
  4. Chu J, Mir A, Gao N, Rosa S, Monson C, Sharma V, et al. A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation. Dis Model Mech. 2013;6:95-105 pubmed publisher
    ..proteins, requires conversion of fructose-6-phosphate to mannose-6-phosphate via the phosphomannose isomerase (MPI) enzyme...
  5. Cline A, Gao N, Flanagan Steet H, Sharma V, Rosa S, Sonon R, et al. A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency. Mol Biol Cell. 2012;23:4175-87 pubmed publisher
    ..In summary, we report the first zebrafish model of PMM2-CDG and uncover novel cellular insights not possible with other systems, including an M6P accumulation mechanism for underglycosylation. ..