Gene Symbol: mmp14b
Description: matrix metallopeptidase 14b (membrane-inserted)
Alias: MT-MMPbeta, matrix metalloproteinase-14, matrix metalloproteinase 14 (membrane-inserted) beta, matrix metalloproteinase 14b (membrane-inserted), zMT-MMP-beta
Species: zebrafish
Products:     mmp14b

Top Publications

  1. Bai S, Thummel R, Godwin A, Nagase H, Itoh Y, Li L, et al. Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Matrix Biol. 2005;24:247-60 pubmed
    ..Taken together, these results indicate that MMPs have an important role during fin regeneration in zebrafish. ..
  2. Zhang J, Bai S, Zhang X, Nagase H, Sarras M. The expression of novel membrane-type matrix metalloproteinase isoforms is required for normal development of zebrafish embryos. Matrix Biol. 2003;22:279-93 pubmed
    ..Axis markers indicated that these effects likely involved processes occurring later than 10 h of embryogenesis. ..
  3. Coyle R, Latimer A, Jessen J. Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling. Exp Cell Res. 2008;314:2150-62 pubmed publisher
    ..Together, our results support the notion that pathways regulating pericellular proteolysis and cell polarity converge to promote efficient cell migration. ..
  4. Lien C, Schebesta M, Makino S, Weber G, Keating M. Gene expression analysis of zebrafish heart regeneration. PLoS Biol. 2006;4:e260 pubmed
    ..Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required. ..
  5. Wyatt R, Keow J, Harris N, Haché C, Li D, Crawford B. The zebrafish embryo: a powerful model system for investigating matrix remodeling. Zebrafish. 2009;6:347-54 pubmed publisher
  6. Golubkov V, Chekanov A, Cieplak P, Aleshin A, Chernov A, Zhu W, et al. The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. J Biol Chem. 2010;285:35740-9 pubmed publisher
    ..Further insight into these novel mechanisms may promote understanding of directional cell motility and lead to the identification of therapeutics to treat PCP-related developmental disorders and malignancy. ..
  7. Yang R, Zhang Y, Huang D, Luo X, Zhang L, Zhu X, et al. Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage. Dis Model Mech. 2017;10:337-348 pubmed publisher
  8. Gamba L, Amin Javaheri A, Kim J, Warburton D, Lien C. Collagenolytic Activity Is Associated with Scar Resolution in Zebrafish Hearts after Cryoinjury. J Cardiovasc Dev Dis. 2017;4: pubmed publisher
    ..These findings suggest that collagenolytic activity may be key to how the zebrafish heart resolves its scar; however, it is not sufficient in mouse hearts that lack efficient myocardial regeneration. ..
  9. Yin C, Kikuchi K, Hochgreb T, Poss K, Stainier D. Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Dev Cell. 2010;18:973-84 pubmed publisher
    ..Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM remodeling during organogenesis. ..

More Information


  1. McGrail M, Hatler J, Kuang X, Liao H, Nannapaneni K, Watt K, et al. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. PLoS ONE. 2011;6:e18826 pubmed publisher
    ..The zebrafish T2/OncZ cancer model will be useful for identifying novel and conserved genetic drivers of human cancers. ..
  2. Janssens E, Gaublomme D, De Groef L, Darras V, Arckens L, Delorme N, et al. Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development. PLoS ONE. 2013;8:e52915 pubmed publisher
    ..b>Mmp14b, on the contrary, does not appear to alter retinal neurogenesis or OT innervation...
  3. Dohn M, Mundell N, Sawyer L, Dunlap J, Jessen J. Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Dev Biol. 2013;383:39-51 pubmed publisher
    ..Together, our results demonstrate that zebrafish Vangl2/Prickle1a and non-canonical Wnt/Frizzled signaling have opposing effects on ECM organization underlying PCP and gastrulation cell movements...
  4. Chu L, Li J, Liu Y, Hu W, Cheng C. Targeted gene disruption in zebrafish reveals noncanonical functions of LH signaling in reproduction. Mol Endocrinol. 2014;28:1785-95 pubmed publisher
    ..LH signaling is demonstrated to control oocyte maturation and ovulation in the ovary. ..