Gene Symbol: mitfb
Description: microphthalmia-associated transcription factor b
Alias: microphthalmia-associated transcription factor, Mitf1
Rojas Muñoz A, Dahm R, NUSSLEIN VOLHARD C. chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis. Dev Biol. 2005;288:348-62 pubmed
..Expression analyses show that otx2 and mitfb are not expressed in the prospective RPE of chk, indicating that the retinal homeobox gene rx3 acts upstream of ..
Lister J, Close J, Raible D. Duplicate mitf genes in zebrafish: complementary expression and conservation of melanogenic potential. Dev Biol. 2001;237:333-44 pubmed
..Here, we describe a second zebrafish mitf gene, mitfb, which may fulfill this role...
Altschmied J, Delfgaauw J, Wilde B, Duschl J, Bouneau L, Volff J, et al
. Subfunctionalization of duplicate mitf genes associated with differential degeneration of alternative exons in fish. Genetics. 2002;161:259-67 pubmed
..Retracing the evolutionary history of mitf genes in vertebrates uncovered the differential recruitment of new introns specific for either the teleost or the bird/mammalian lineage. ..
Lister J, Lane B, Nguyen A, Lunney K. Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec. Dev Dyn. 2011;240:2529-38 pubmed publisher
..The zebrafish genome contain two mitf (mitfa and mitfb), two tfe3 (tfe3a and tfe3b), and single tfeb and tfec genes; this distribution is shared with other teleosts...
Lane B, Lister J. Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development. PLoS ONE. 2012;7:e49357 pubmed publisher
..role of the three Otx transcription factors (Otx1a, Otx1b, and Otx2) and two Mitf transcription factors (Mitfa and Mitfb) in the development of the zebrafish RPE was explored in these experiments...
Zeng J, Yan J, Wang T, Mosbrook Davis D, Dolan K, Christensen R, et al
. Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins. Nucleic Acids Res. 2008;36:e8 pubmed
..Our yeast screening strategy, combined with bioinformatics approaches, will allow both detailed and high-throughput characterization of transcription factors, scalable to the analysis of all putative DNA-binding proteins. ..
Li M, Zhu F, Hong Y. Differential evolution of duplicated medakafish mitf genes. Int J Biol Sci. 2013;9:496-508 pubmed publisher
..Here we report the evolution of mitf duplicate, mitf1 and mitf2, in the fish medaka (Oryzias latipes), which encode medaka co-homologs Mitf1 and Mitf2 of the mouse Mitf...
Baek S, Lee S. Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of MITF via the intracellular cAMP and p38/JNK signalling pathways. Exp Dermatol. 2015;24:761-6 pubmed publisher
..Together, these results suggest that sesamol strongly inhibits melanin biosynthesis, and therefore, sesamol represents a new skin-whitening agent for use in cosmetics. ..
Baek S, Lee S. Omeprazole inhibits melanin biosynthesis in melan-a cells and zebrafish. Exp Dermatol. 2016;25:239-41 pubmed publisher