Gene Symbol: mir150
Description: microRNA 150
Lin Y, Kuo M, Yu J, Kuo H, Lin R, Lo W, et al
. c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development. Mol Biol Evol. 2008;25:2189-98 pubmed publisher
..Our findings suggest that c-Myb is an evolutionally conserved target of miR-150 and miR-150/c-Myb interaction is important for embryonic development and possibly oncogenesis. ..
Guillon Munos A, Dambrine G, Richerioux N, Coupeau D, Muylkens B, Rasschaert D. The chicken miR-150 targets the avian orthologue of the functional zebrafish MYB 3'UTR target site. BMC Mol Biol. 2010;11:67 pubmed publisher
..Our study of the avian MYB/gga-miR-150 interaction shows a conservation of miR-150 target site functionality between chicken and zebrafish that does not extend to mammals. ..
Grabher C, Payne E, Johnston A, Bolli N, Lechman E, Dick J, et al
. Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb. Leukemia. 2011;25:506-14 pubmed publisher
..These results support the notion that miRNAs not only function to provide precision to developmental programs but also are essential determinants in the control of variable potential functions of a single gene during hematopoiesis. ..
Nicoli S, Knyphausen C, Zhu L, Lakshmanan A, Lawson N. miR-221 is required for endothelial tip cell behaviors during vascular development. Dev Cell. 2012;22:418-29 pubmed publisher
..These results identify miR-221 as an important regulatory node through which tip cell migration and proliferation are controlled during angiogenesis. ..
Yin V, Lepilina A, Smith A, Poss K. Regulation of zebrafish heart regeneration by miR-133. Dev Biol. 2012;365:319-27 pubmed publisher
..Our results reveal dynamic regulation of miRNAs during heart regeneration, and indicate that miR-133 restricts injury-induced cardiomyocyte proliferation. ..
Banjo T, Grajcarek J, Yoshino D, Osada H, Miyasaka K, Kida Y, et al
. Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21. Nat Commun. 2013;4:1978 pubmed publisher
..We conclude that miR-21 is a central component of a flow-controlled mechanotransduction system in a physicogenetic regulatory loop. ..
Craig T, Zhang Y, Magis A, Funk C, Price N, Ekker S, et al
. Detection of 1?,25-dihydroxyvitamin D-regulated miRNAs in zebrafish by whole transcriptome sequencing. Zebrafish. 2014;11:207-18 pubmed publisher
..Our data show that 1?,25(OH)?D? regulates miRNA in zebrafish larvae in vivo and could thereby influence vitamin D-sensitive mRNA concentrations. ..
Huang C, Chen N, Wu X, Huang C, He Y, Tang R, et al
. The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1Î± and functions in cellular adaptations. FASEB J. 2015;29:4901-13 pubmed publisher
Merrigan S, Kennedy B. Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre-miR-21 and VEGF. Br J Pharmacol. 2017;174:2636-2651 pubmed publisher
..These targets should be further evaluated as molecular hallmarks of, and therapeutic targets for pathological ocular neovascularization. ..