Gene Symbol: mir126a
Description: microRNA 126a
Alias: dre-mir-126, dre-mir-126a, mir126
Species: zebrafish
Products:     mir126a

Top Publications

  1. Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty K, Lawson N. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 2010;464:1196-200 pubmed publisher
    ..Taken together, our work describes a novel genetic mechanism in which a microRNA facilitates integration of a physiological stimulus with growth factor signalling in endothelial cells to guide angiogenesis. ..
  2. Fish J, Santoro M, Morton S, Yu S, Yeh R, Wythe J, et al. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008;15:272-84 pubmed publisher
    ..These findings illustrate that a single miRNA can regulate vascular integrity and angiogenesis, providing a new target for modulating vascular formation and function. ..
  3. Lagendijk A, Goumans M, Burkhard S, Bakkers J. MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production. Circ Res. 2011;109:649-57 pubmed publisher
    ..MiR-23 in the embryonic heart is required to restrict endocardial cushion formation by inhibiting Has2 expression and extracellular hyaluronic acid production. ..
  4. Grabher C, Payne E, Johnston A, Bolli N, Lechman E, Dick J, et al. Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb. Leukemia. 2011;25:506-14 pubmed publisher
    ..These results support the notion that miRNAs not only function to provide precision to developmental programs but also are essential determinants in the control of variable potential functions of a single gene during hematopoiesis. ..
  5. Zhao Y, Xiong Q, Xie P. Analysis of microRNA expression in embryonic developmental toxicity induced by MC-RR. PLoS ONE. 2011;6:e22676 pubmed publisher
  6. Francia S, Michelini F, Saxena A, Tang D, de Hoon M, Anelli V, et al. Site-specific DICER and DROSHA RNA products control the DNA-damage response. Nature. 2012;488:231-5 pubmed publisher
    ..Our results describe an unanticipated direct role of a novel class of ncRNAs in the control of DDR activation at sites of DNA damage. ..
  7. Novodvorsky P, Watson O, Gray C, Wilkinson R, Reeve S, Smythe C, et al. klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS ONE. 2015;10:e0141611 pubmed publisher
    ..The klf2ash317 mutation produces a truncated Klf2a protein but, unlike morpholino induced klf2a knockdown, does not affect cardiovascular development. ..
  8. Banjo T, Grajcarek J, Yoshino D, Osada H, Miyasaka K, Kida Y, et al. Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21. Nat Commun. 2013;4:1978 pubmed publisher
    ..We conclude that miR-21 is a central component of a flow-controlled mechanotransduction system in a physicogenetic regulatory loop. ..
  9. Presslauer C, Tilahun Bizuayehu T, Kopp M, Fernandes J, Babiak I. Dynamics of miRNA transcriptome during gonadal development of zebrafish. Sci Rep. 2017;7:43850 pubmed publisher
    ..This report is the most comprehensive analysis of the miRNA repertoire in zebrafish gonads during the sexual development to date and provides an important database from which functional studies can be performed. ..

More Information


  1. Chen J, Zhu R, Li F, Liang Y, Wang C, Qin Y, et al. MicroRNA-126a Directs Lymphangiogenesis Through Interacting With Chemokine and Flt4 Signaling in Zebrafish. Arterioscler Thromb Vasc Biol. 2016;36:2381-2393 pubmed
    ..Our results suggest that these key regulators of lymphangiogenesis may be involved in lymphatic pathogenesis of cardiovascular diseases. ..
  2. Pauli A, Montague T, Lennox K, Behlke M, Schier A. Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish. PLoS ONE. 2015;10:e0139504 pubmed publisher
    ..Despite this drawback, quantitation of knockdown efficiency and the ability to degrade lncRNAs make ASOs a useful knockdown reagent in zebrafish. ..
  3. Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi H, et al. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun. 2015;6:7194 pubmed publisher
    ..Our results suggest that eIF1A is a novel component of the Ago2-centred RNA-induced silencing complexes (RISCs) and augments Ago2-dependent RNAi and miRNA biogenesis. ..
  4. Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, et al. Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins. Dev Cell. 2015;32:181-90 pubmed publisher
    ..Our work reveals a β1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by CCM proteins. This regulation prevents angiogenic overgrowth and ensures the quiescence of endothelial cells. ..
  5. Craig T, Zhang Y, Magis A, Funk C, Price N, Ekker S, et al. Detection of 1?,25-dihydroxyvitamin D-regulated miRNAs in zebrafish by whole transcriptome sequencing. Zebrafish. 2014;11:207-18 pubmed publisher
    ..Our data show that 1?,25(OH)?D? regulates miRNA in zebrafish larvae in vivo and could thereby influence vitamin D-sensitive mRNA concentrations. ..
  6. Xiao A, Wang Z, Hu Y, Wu Y, Luo Z, Yang Z, et al. Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic Acids Res. 2013;41:e141 pubmed publisher
    ..To facilitate the analyses and application of existing ZFN, TALEN and CRISPR/Cas data, we have updated our EENdb database to provide a chromosomal view of all reported engineered endonucleases targeting human and zebrafish genomes. ..
  7. Sessa R, Seano G, di Blasio L, Gagliardi P, Isella C, Medico E, et al. The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85?. Biochim Biophys Acta. 2012;1823:1925-35 pubmed publisher
    ..Our findings suggest that miR-126-mediated phosphoinositide-3-kinase regulation, not only fine-tunes VEGF-signaling, but it strongly enhances the activities of Ang-1 on vessel stabilization and maturation. ..
  8. He X, Yan Y, DeLaurier A, Postlethwait J. Observation of miRNA gene expression in zebrafish embryos by in situ hybridization to microRNA primary transcripts. Zebrafish. 2011;8:1-8 pubmed publisher
  9. Zou J, Li W, Li Q, Li X, Zhang J, Liu G, et al. Two functional microRNA-126s repress a novel target gene p21-activated kinase 1 to regulate vascular integrity in zebrafish. Circ Res. 2011;108:201-9 pubmed publisher
    ..Two functional endothelial cell-specific miRNAs, miR-126a and miR-126b, synergistically regulate zebrafish vascular integrity, and pak1 is a critical target of miR-126a/b in vascular development. ..