Gene Symbol: mhc1uba
Description: major histocompatibility complex class I UBA
Alias: zgc:91955, major histocompatibility complex class I UBA
Species: zebrafish

Top Publications

  1. Hansen J, Strassburger P, Du Pasquier L. Conservation of an alpha 2 domain within the teleostean world, MHC class I from the rainbow trout Oncorhynchus mykiss. Dev Comp Immunol. 1996;20:417-25 pubmed
    ..Onmy-UA-C32 may therefore represent a MHC class Ia gene in trout as well as providing new insights regarding the evolution of the MHC within teleost species. ..
  2. Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang Z, et al. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol. 2010;29:399-406 pubmed publisher
    ..This study shows the protective effects of interferon against a DNA-virus in fish for the first time and provides information about the efficacy of fish interferon that will prove useful in possible therapeutic applications. ..
  3. Dirscherl H, Yoder J. Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish. Immunogenetics. 2014;66:185-98 pubmed publisher
    ..Finally, we present a gene nomenclature system for the Z genes consistent with MHC nomenclature in other species and with the zebrafish gene nomenclature guidelines. ..
  4. Dirscherl H, Yoder J. A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant. Immunogenetics. 2015;67:501-13 pubmed publisher
  5. Encinas P, Rodriguez Milla M, Novoa B, Estepa A, Figueras A, Coll J. Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. BMC Genomics. 2010;11:518 pubmed publisher
  6. de Jong J, Burns C, Chen A, Pugach E, Mayhall E, Smith A, et al. Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 2011;117:4234-42 pubmed publisher
  7. McConnell S, Restaino A, de Jong J. Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. Immunogenetics. 2014;66:199-213 pubmed publisher
    ..Altogether, ten full-length zebrafish class I genes were analyzed, mhc1uba through mhc1uka. Expression data and sequence properties indicate that most are candidate classical genes...
  8. Dirscherl H, McConnell S, Yoder J, de Jong J. The MHC class I genes of zebrafish. Dev Comp Immunol. 2014;46:11-23 pubmed publisher
    ..Finally, we discuss how recent findings have shed new light on the remarkably diverse MHC loci of this species. ..
  9. McConnell S, Hernandez K, Wcisel D, Kettleborough R, Stemple D, Yoder J, et al. Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. Proc Natl Acad Sci U S A. 2016;113:E5014-23 pubmed publisher

More Information


  1. Wu X, Hu Y, Xue N, Ren S, Chen S, Nie P, et al. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Dev Comp Immunol. 2017;68:58-68 pubmed publisher
    ..All together, these results demonstrate that zebrafish NLRC5 is involved in IFN-independent antiviral response, and also functions as a transcriptional regulator of MHC class II genes. ..