mfap4

Summary

Gene Symbol: mfap4
Description: microfibril associated protein 4
Alias: zgc:77076, microfibrillar-associated protein 4
Species: zebrafish

Top Publications

  1. Shiau C, Monk K, Joo W, Talbot W. An anti-inflammatory NOD-like receptor is required for microglia development. Cell Rep. 2013;5:1342-52 pubmed publisher
    ..Together, these results demonstrate that NLRC3-like prevents inappropriate macrophage activation, thereby allowing normal microglial development. ..
  2. Zakrzewska A, Cui C, Stockhammer O, Benard E, Spaink H, Meijer A. Macrophage-specific gene functions in Spi1-directed innate immunity. Blood. 2010;116:e1-11 pubmed publisher
    ..Colocalization studies with neutrophil and macrophage markers revealed that genes cxcr3.2, mpeg1, ptpn6, and mfap4 were expressed specifically in early embryonic macrophages...
  3. Torraca V, Cui C, Boland R, Bebelman J, van der Sar A, Smit M, et al. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Dis Model Mech. 2015;8:253-69 pubmed publisher
    ..The demonstration of a conserved CXCR3-CXCL11 signaling axis in zebrafish extends the translational applicability of this model for studying diseases involving the innate immune system. ..
  4. Walton E, Cronan M, Beerman R, Tobin D. The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish. PLoS ONE. 2015;10:e0138949 pubmed publisher
    ..Here, we describe mfap4 as a macrophage-specific promoter capable of producing transgenic lines in which transgene expression within ..
  5. Zhang D, Wang J, Zhou C, Xiao W. Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis. Mech Dev. 2017;143:42-52 pubmed publisher
  6. Li J, Li K, Dong X, Liang D, Zhao Q. Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis. Dev Dyn. 2014;243:1544-53 pubmed publisher
    ..Development of both mfap4(+) macrophages and mpx(+) neutrophils was abolished in ncor2 morphants, whereas development of mpx(+) neutrophils ..
  7. Meireles A, Shiau C, Guenther C, Sidik H, Kingsley D, Talbot W. The phosphate exporter xpr1b is required for differentiation of tissue-resident macrophages. Cell Rep. 2014;8:1659-1667 pubmed publisher
    ..Single mutants for xpr1a were viable, and double mutants for xpr1b;xpr1a were similar to xpr1b single mutants. Our genetic analysis reveals a specific role for the phosphate exporter Xpr1 in the differentiation of tissue macrophages. ..
  8. Jin H, Huang Z, Chi Y, Wu M, Zhou R, Zhao L, et al. c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 2016;128:415-26 pubmed publisher
    ..Our study indicates that c-MYB is an intrinsic master regulator for neutrophil terminal differentiation and a potential target in SGD patients. ..
  9. Rydeen A, Waxman J. Cyp26 Enzymes Facilitate Second Heart Field Progenitor Addition and Maintenance of Ventricular Integrity. PLoS Biol. 2016;14:e2000504 pubmed publisher
    ..These novel findings indicate a primary effect of RA-induced OFT defects is disruption of the extracellular environment, which compromises both SHF recruitment and FHF ventricular integrity. ..

More Information

Publications23

  1. Xu J, Wang T, Wu Y, Jin W, Wen Z. Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. Dev Cell. 2016;38:214-22 pubmed publisher
    ..Our study reveals that microglia colonization of developing zebrafish midbrain is triggered by apoptotic neuronal death, possibly via releasing lysophosphatidylcholine. ..
  2. Mahony C, Fish R, Pasche C, Bertrand J. tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis. Blood. 2016;128:1336-45 pubmed publisher
    ..The full comprehension of the mechanisms induced by tfec will represent an important milestone toward the expansion of HSCs for regenerative purposes. ..
  3. Wei Y, Xu J, Zhang W, Wen Z, Liu F. RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development. 2016;143:2103-10 pubmed publisher
  4. Gerri C, Marín Juez R, Marass M, Marks A, Maischein H, Stainier D. Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish. Nat Commun. 2017;8:15492 pubmed publisher
    ..Altogether, our data provide genetic evidence that Hif-1α regulates interactions between macrophages and endothelial cells starting with the mobilization of macrophages from the AGM. ..
  5. Shen K, Sidik H, Talbot W. The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. Cell Rep. 2016;14:547-559 pubmed publisher
    ..Our analysis reveals an essential role of the Rag-Ragulator complex in proper lysosome function and phagocytic flux in microglia. ..
  6. Wang S, He Q, Ma D, Xue Y, Liu F. Irf4 Regulates the Choice between T Lymphoid-Primed Progenitor and Myeloid Lineage Fates during Embryogenesis. Dev Cell. 2015;34:621-31 pubmed publisher
    ..1 expression to prevent an alternate fate. Our findings provide insight into the fate determination mechanism of T lymphoid-primed progenitors. ..
  7. Cronan M, Beerman R, ROSENBERG A, Saelens J, Johnson M, Oehlers S, et al. Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. Immunity. 2016;45:861-876 pubmed publisher
    ..Thus, during mycobacterial infection, granuloma macrophages are broadly reprogrammed by epithelial modules, and this reprogramming alters the trajectory of infection and the associated immune response. ..
  8. Oehlers S, Cronan M, Scott N, Thomas M, Okuda K, Walton E, et al. Interception of host angiogenic signalling limits mycobacterial growth. Nature. 2015;517:612-5 pubmed publisher
  9. Marín Juez R, Jong Raadsen S, Yang S, Spaink H. Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. J Endocrinol. 2014;222:229-41 pubmed publisher
    ..In addition, our data will be very useful in further studies of the function of immunological determinants in a non-obese model system. ..
  10. Shiau C, Kaufman Z, Meireles A, Talbot W. Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish. PLoS ONE. 2015;10:e0117513 pubmed publisher
    ..Our study defines distinct requirement for irf8 in myelopoiesis before and after transition to the adult hematopoietic system. ..
  11. He Q, Zhang C, Wang L, Zhang P, Ma D, Lv J, et al. Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 2015;125:1098-106 pubmed publisher
    ..Our findings establish a previously unrecognized link between inflammatory signaling and HSPC emergence, and provide new insights into regenerative medicine and novel therapies to treat innate immune-related diseases. ..
  12. Kanther M, Tomkovich S, Xiaolun S, Grosser M, Koo J, Flynn E, et al. Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. Cell Microbiol. 2014;16:1053-67 pubmed publisher
  13. Wang K, Fang X, Ma N, Lin Q, Huang Z, Liu W, et al. Myeloperoxidase-deficient zebrafish show an augmented inflammatory response to challenge with Candida albicans. Fish Shellfish Immunol. 2015;44:109-16 pubmed publisher
    ..albicans infection. These findings indicate that myeloperoxidase deficiency alters the inflammatory response to fungal infection. ..
  14. Dai Y, Zhu L, Huang Z, Zhou M, Jin W, Liu W, et al. Cebp? is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. J Genet Genomics. 2016;43:593-600 pubmed publisher
    ..We further show that Cebp?, perhaps acting cooperatively with Runx1, plays a critical role in embryonic neutrophil maintenance. Our findings reveal a new role of Cebp? in embryonic myelopoiesis. ..