Gene Symbol: mertka
Description: c-mer proto-oncogene tyrosine kinase a
Alias: mertk, si:ch1073-268l12.2, tyrosine-protein kinase Mer
Russell M, Raeker M, Geisler S, Thomas P, Simmons T, Bernat J, et al
. Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations. Hum Mol Genet. 2014;23:4272-84 pubmed publisher
..We postulate that heterozygous loss of FBLN7 and TMEM87B account for some of the clinical features, including cardiac defects and craniofacial abnormalities associated with 2q13 deletion syndrome. ..
Maugars G, Dufour S. Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians. PLoS ONE. 2015;10:e0135184 pubmed publisher
..This study revises the evolutionary scenario and nomenclature of gonadotropin receptors, and opens new research avenues on the roles of duplicated LHR in actinopterygians. ..
Jiang C, Qin B, Liu G, Sun X, Shi H, Ding S, et al
. MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway. Oncotarget. 2016;7:52340-52353 pubmed publisher
..MiR-184 promotes RPE differentiation via inhibiting the AKT2/mTOR signaling pathway. MiR-184 based supplementary therapeutics and mTOR blocker, like rapamycin, are prospective options for AMD treatment. ..
Chen X, Sheng X, Zhuang W, Sun X, Liu G, Shi X, et al
. GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity. Genet Med. 2017;19:945-954 pubmed publisher
..The diverse pathogenic modes of GUCA1A mutations may explain the phenotypic diversities.Genet Med advance online publication 26 January 2017. ..
Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, et al
. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017;26:2335-2345 pubmed publisher
..We further found that the phagocytosis-associated protein MERTK was significantly reduced in CERKL-/- zebrafish...