Gene Symbol: melanopsin
Description: opsin 4.1
Alias: opn4, opn4l, opn4m2, melanopsin-like, mammalian-like melanopsin-2, melanopsin opn4m2, opn4c, opsin 4 (melanopsin), opsin 4, like
Species: zebrafish
Products:     melanopsin

Top Publications

  1. Bellingham J, Chaurasia S, Melyan Z, Liu C, Cameron M, Tarttelin E, et al. Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. PLoS Biol. 2006;4:e254 pubmed
    In mammals, the melanopsin gene (Opn4) encodes a sensory photopigment that underpins newly discovered inner retinal photoreceptors...
  2. Davies W, Zheng L, Hughes S, Tamai T, Turton M, Halford S, et al. Functional diversity of melanopsins and their global expression in the teleost retina. Cell Mol Life Sci. 2011;68:4115-32 pubmed publisher
    b>Melanopsin (OPN4) is an opsin photopigment that, in mammals, confers photosensitivity to retinal ganglion cells and regulates circadian entrainment and pupil constriction...
  3. Matos Cruz V, Blasic J, Nickle B, Robinson P, Hattar S, Halpern M. Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. PLoS ONE. 2011;6:e25111 pubmed publisher
    ..b>Melanopsin, another photopigment first discovered in Xenopus melanophores (Opn4x), is expressed in a small subset of ..
  4. Shiraki T, Kojima D, Fukada Y. Light-induced body color change in developing zebrafish. Photochem Photobiol Sci. 2010;9:1498-504 pubmed publisher
    ..We also discussed the putative role(s) of opsin-type photoreceptive molecules in the light-induced body color change of the larval zebrafish. ..
  5. Morrow J, Lazic S, Chang B. A novel rhodopsin-like gene expressed in zebrafish retina. Vis Neurosci. 2011;28:325-35 pubmed publisher
    ..The discovery of a new previously uncharacterized opsin gene in zebrafish retina is surprising given its status as a model system for studies of vertebrate vision and visual development. ..
  6. Cavallari N, Frigato E, Vallone D, Fröhlich N, López Olmeda J, Foá A, et al. A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception. PLoS Biol. 2011;9:e1001142 pubmed publisher
    ..This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway.
  7. Backfisch B, Veedin Rajan V, Fischer R, Lohs C, Arboleda E, Tessmar Raible K, et al. Stable transgenesis in the marine annelid Platynereis dumerilii sheds new light on photoreceptor evolution. Proc Natl Acad Sci U S A. 2013;110:193-8 pubmed publisher
    ..Finally, expression analysis of opn4×-2 and opn4m-2, two zebrafish orthologs of Platynereis r-opsin, reveals that these genes share expression in the ..
  8. Kokel D, Dunn T, Ahrens M, Alshut R, Cheung C, Saint Amant L, et al. Identification of nonvisual photomotor response cells in the vertebrate hindbrain. J Neurosci. 2013;33:3834-43 pubmed publisher
    ..Pharmacological inhibition of the visual cycle blocks PMR behaviors, suggesting that opsin-based photoreceptors control this behavior. These data represent the first known light-sensing circuit in the vertebrate hindbrain. ..
  9. Sousa J, Magalhães Marques K, da Silveira Cruz Machado S, Moraes M, Castrucci A. Dexamethasone Modulates Nonvisual Opsins, Glucocorticoid Receptor, and Clock Genes in Danio rerio ZEM-2S Cells. Biomed Res Int. 2017;2017:8459385 pubmed publisher
    ..Taken together, these data demonstrate that D. rerio ZEM-2S cells possess a photosensitive system due to melanopsin expression which results in an oscillatory profile of clock genes in response to LD cycle...

More Information


  1. Yang H, Zhou Y, Gu J, Xie S, Xu Y, Zhu G, et al. Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS ONE. 2013;8:e64058 pubmed publisher
    ..Our study provides ample information for further study about the molecular and cellular mechanisms underlying vertebrate development. ..
  2. Blasic J, Matos Cruz V, Ujla D, Cameron E, Hattar S, Halpern M, et al. Identification of critical phosphorylation sites on the carboxy tail of melanopsin. Biochemistry. 2014;53:2644-9 pubmed publisher
    ..The photopigment melanopsin possesses an unusually long carboxy tail containing 37 serine and threonine sites that are potential sites for ..