Gene Symbol: mdkb
Description: midkine b
Alias: cb518, fb79b05, fj33b02, fj48a12, mdk, mdk2, plei2, wu:fb79b05, wu:fj33b02, wu:fj48a12, midkine b, midkine-related growth factor b, pleiotrophin 2
Species: zebrafish

Top Publications

  1. Patterson L, Bain E, Parichy D. Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reiteration and Danio pattern evolution. Nat Commun. 2014;5:5299 pubmed publisher
    ..Our results identify novel mechanisms of pattern development and illustrate how pattern diversity can be generated when a core network of pigment-cell autonomous interactions is coupled with changes in pigment cell differentiation. ..
  2. Winkler C, Moon R. Zebrafish mdk2, a novel secreted midkine, participates in posterior neurogenesis. Dev Biol. 2001;229:102-18 pubmed
    ..Here we describe a novel secreted factor in zebrafish, named mdk2, related to the midkine family of heparin-binding growth factors that is involved in posterior neural development...
  3. Yin J, Xia J, Du X, Liu J, Zhou L, Hong Y, et al. Developmental expression of CagMdkb during gibel carp embryogenesis. Int J Dev Biol. 2007;51:761-9 pubmed
    ..Its full length cDNA is 1091 bp and encodes a sequence of 147 amino acids, which shows 97.3% identity to zebrafish Mdkb on the amino acid level...
  4. Calinescu A, Raymond P, Hitchcock P. Midkine expression is regulated by the circadian clock in the retina of the zebrafish. Vis Neurosci. 2009;26:495-501 pubmed publisher
    ..the expression of the genes encoding the secreted heparin-binding growth factors, midkine-a (mdka) and midkine-b (mdkb), in the retina of the zebrafish...
  5. Schüttler A, Reiche K, Altenburger R, Busch W. The Transcriptome of the Zebrafish Embryo After Chemical Exposure: A Meta-Analysis. Toxicol Sci. 2017;157:291-304 pubmed publisher
    ..In future, improved time- and concentration-resolved experiments should offer better understanding of stress response patterns and access to mechanistic information. ..
  6. Liedtke D, Winkler C. Midkine-b regulates cell specification at the neural plate border in zebrafish. Dev Dyn. 2008;237:62-74 pubmed
    ..Here we show that one member of this family, Midkine-b (Mdkb), is responsible for establishment of the neural plate border in zebrafish...
  7. Calinescu A, Vihtelic T, Hyde D, Hitchcock P. Cellular expression of midkine-a and midkine-b during retinal development and photoreceptor regeneration in zebrafish. J Comp Neurol. 2009;514:1-10 pubmed publisher
    ..In a microarray screen to discover such factors, we identified midkine-b (mdkb). Midkine is a highly conserved heparin-binding growth factor with numerous biological functions...
  8. Winkler C, Schafer M, Duschl J, Schartl M, Volff J. Functional divergence of two zebrafish midkine growth factors following fish-specific gene duplication. Genome Res. 2003;13:1067-81 pubmed
    ..Here, we show the presence of two functional mdk genes named mdka and mdkb in zebrafish and rainbow trout...
  9. Cao J, Navis A, Cox B, Dickson A, Gemberling M, Karra R, et al. Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. Development. 2016;143:232-43 pubmed publisher
    ..Our study defines a new platform for the discovery of epicardial lineage markers, genetic tools, and mechanisms of heart regeneration. ..

More Information


  1. Crosier P, Bardsley A, Horsfield J, Krassowska A, Lavallie E, Collins Racie L, et al. In situ hybridization screen in zebrafish for the selection of genes encoding secreted proteins. Dev Dyn. 2001;222:637-44 pubmed
  2. Neumann J, Chandler G, Damoulis V, Fustino N, Lillard K, Looijenga L, et al. Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proc Natl Acad Sci U S A. 2011;108:13153-8 pubmed publisher
    ..These results indicate a germ-cell-autonomous role for BMP signal transduction in germ-cell differentiation, and highlight the importance of the BMP pathway in human GCTs...
  3. Lim J, Yao S, Graf M, Winkler C, Yang D. Structure-function analysis of full-length midkine reveals novel residues important for heparin binding and zebrafish embryogenesis. Biochem J. 2013;451:407-15 pubmed publisher
    ..Our findings provide new insights into the structural features of full-length midkine relevant for embryogenesis, and unravel additional therapeutic routes targeting the N-terminal half domain and conserved hinge. ..