mcu

Summary

Gene Symbol: mcu
Description: mitochondrial calcium uniporter
Alias: ccdc109a, wu:fi24a01, zgc:153607, calcium uniporter protein, mitochondrial, coiled-coil domain-containing protein 109A
Species: zebrafish

Top Publications

  1. Prudent J, Popgeorgiev N, Bonneau B, Thibaut J, Gadet R, Lopez J, et al. Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish. Nat Commun. 2013;4:2330 pubmed publisher
    ..molecular studies in zebrafish indicate that Bcl-wav and the recently identified mitochondrial calcium uniporter (MCU) contribute to the formation of the notochord axis by controlling blastomere convergence and extension movements ..
  2. Peng X, Shang G, Wang W, Chen X, Lou Q, Zhai G, et al. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3. Cell Rep. 2017;19:1444-1455 pubmed publisher
    ..Our results demonstrate that regulation of 1α,25(OH)2D3 during lipid metabolism occurs through the regulation of Pgc1a for mitochondrial biogenesis and oxidative metabolism within zebrafish VAT. ..
  3. Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, et al. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. elife. 2015;4: pubmed publisher
    ..embryos whereas VDAC2 deficiency attenuates efsevin's rescue effect and that VDAC2 functions synergistically with MCU to suppress cardiac fibrillation in tremblor...
  4. Soman S, Keatinge M, Moein M, Da Costa M, Mortiboys H, Skupin A, et al. Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1-/- zebrafish. Eur J Neurosci. 2017;45:528-535 pubmed publisher
    ..We report that both genetic and pharmacological inactivation of the mitochondrial calcium uniporter (MCU), located in the inner mitochondrial membrane, prevents dopaminergic neuronal cell loss in pink1Y431 * ..