mcoln1a

Summary

Gene Symbol: mcoln1a
Description: mucolipin 1a
Alias: mcoln1, mcoln1.1, zgc:63619, mucolipin-1, mucolipin 1, mucolipin 1.1
Species: zebrafish

Top Publications

  1. Slade L, Cowie A, Martyniuk C, Kienesberger P, Pulinilkunnil T. Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio). J Pharmacol Exp Ther. 2017;361:375-385 pubmed publisher
    ..Our data demonstrate that dieldrin induces genes associated with cardiovascular dysfunction and compromised lysosomal physiology, thereby identifying a novel mechanism for pesticide-induced cardiotoxicity. ..
  2. Li H, Pei W, Vergarajauregui S, Zerfas P, Raben N, Burgess S, et al. Novel degenerative and developmental defects in a zebrafish model of mucolipidosis type IV. Hum Mol Genet. 2017;26:2701-2718 pubmed publisher
    ..There is currently no effective treatment. MLIV is caused by mutations in MCOLN1, a lysosomal cation channel from the transient receptor potential (TRP) family...
  3. Benini A, Bozzato A, Mantovanelli S, Calvarini L, Giacopuzzi E, Bresciani R, et al. Characterization and expression analysis of mcoln1.1 and mcoln1.2, the putative zebrafish co-orthologs of the gene responsible for human mucolipidosis type IV. Int J Dev Biol. 2013;57:85-93 pubmed publisher
    Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder caused by mutations in the MCOLN1 gene coding for mucolipin-1 (TRPML1)...