Gene Symbol: mc1r
Description: melanocortin 1 receptor
Alias: melanocyte-stimulating hormone receptor, melanocortin 1 receptor protein
Species: zebrafish

Top Publications

  1. Haitina T, Klovins J, Takahashi A, Löwgren M, Ringholm A, Enberg J, et al. Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes. BMC Evol Biol. 2007;7:101 pubmed
    ..This study shows presence of MC receptors in agnathans indicating early signs of specific functions of melanocortin receptor subtypes. ..
  2. Selz Y, Braasch I, Hoffmann C, Schmidt C, Schultheis C, Schartl M, et al. Evolution of melanocortin receptors in teleost fish: the melanocortin type 1 receptor. Gene. 2007;401:114-22 pubmed publisher
    The melanocortin type 1 receptor (Mc1r) belongs to a family of G-protein-coupled receptors involved in various physiological processes in vertebrates...
  3. Seberg H, Van Otterloo E, Loftus S, Liu H, Bonde G, Sompallae R, et al. TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genet. 2017;13:e1006636 pubmed publisher
    ..that expression of a small subset of genes underlying pigmentation phenotypes is TFAP2A-dependent, including Dct, Mc1r, Mlph, and Pmel...
  4. Logan D, Bryson Richardson R, Taylor M, Currie P, Jackson I. Sequence characterization of teleost fish melanocortin receptors. Ann N Y Acad Sci. 2003;994:319-30 pubmed
    ..We have confirmed the sequences of these 10 genes and show the comparison of the amino acid sequences of the encoded proteins with the orthologous receptor in other vertebrates. ..
  5. Richardson J, Lundegaard P, Reynolds N, Dorin J, Porteous D, Jackson I, et al. mc1r Pathway regulation of zebrafish melanosome dispersion. Zebrafish. 2008;5:289-95 pubmed publisher
    ..In mammals and birds, the melanocortin-1-receptor (MC1R) responds to MSH, and stimulates the synthesis of black eumelanin...
  6. Sánchez E, Rubio V, Thompson D, Metz J, Flik G, Millhauser G, et al. Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). Am J Physiol Regul Integr Comp Physiol. 2009;296:R1293-306 pubmed publisher
    ..This suggests that inverse agonism and competitive antagonism operate through different intracellular signaling pathways, a view that opens up new targets for the treatment of melanocortin-induced metabolic syndrome. ..
  7. Zhang C, Song Y, Thompson D, Madonna M, Millhauser G, Toro S, et al. Pineal-specific agouti protein regulates teleost background adaptation. Proc Natl Acad Sci U S A. 2010;107:20164-71 pubmed publisher
  8. Renquist B, Zhang C, Williams S, Cone R. Development of an assay for high-throughput energy expenditure monitoring in the zebrafish. Zebrafish. 2013;10:343-52 pubmed publisher
  9. Zhang Y, Wang L, Zhou W, Wang H, Zhang J, Deng S, et al. Tissue factor pathway inhibitor-2: a novel gene involved in zebrafish central nervous system development. Dev Biol. 2013;381:38-49 pubmed publisher
    ..Furthermore, Morpholino knockdown of ztfpi-2 resulted in upregulation of neuronal markers while downregulation of glial markers, providing evidence that the Notch pathway is probably involved in ztfpi-2-mediated CNS development. ..

More Information


  1. Nesan D, Vijayan M. The transcriptomics of glucocorticoid receptor signaling in developing zebrafish. PLoS ONE. 2013;8:e80726 pubmed publisher
    ..Together, this study underscores a critical role for glucocorticoid signaling in programming molecular events essential for zebrafish development. ..
  2. Shainer I, Buchshtab A, Hawkins T, Wilson S, Cone R, Gothilf Y. Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish. Sci Rep. 2017;7:44777 pubmed publisher
  3. Kumar A, Bhandari A, Sinha R, Goyal P, Grapputo A. Spliceosomal intron insertions in genome compacted ray-finned fishes as evident from phylogeny of MC receptors, also supported by a few other GPCRs. PLoS ONE. 2011;6:e22046 pubmed publisher
    ..In addition to repetitive elements, genome compaction is now believed to be a new hallmark that promotes intron insertions, as it requires rapid DNA breakage and subsequent repair processes to gain back normal functionality. ..
  4. Zhang C, Forlano P, Cone R. AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metab. 2012;15:256-64 pubmed publisher
    ..This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation. ..
  5. Cortés R, Agulleiro M, Navarro S, Guillot R, Sánchez E, Cerdá Reverter J. Melanocortin receptor accessory protein 2 (MRAP2) interplays with the zebrafish melanocortin 1 receptor (MC1R) but has no effect on its pharmacological profile. Gen Comp Endocrinol. 2014;201:30-6 pubmed publisher
    ..The MC1R fill the extension locus, which is primarily responsible for the regulation of pigmentation...
  6. Guillot R, Muriach B, Rocha A, Rotllant J, Kelsh R, Cerdá Reverter J. Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner. PLoS ONE. 2016;11:e0166152 pubmed publisher
    ..Thus, fish gender is now shown to be an important variable that should be controlled in future studies of fish melanogenesis. ..