Gene Symbol: mb
Description: myoglobin
Alias: zgc:65819, zgc:77764, myoglobin
Species: zebrafish

Top Publications

  1. Corti P, Ieraci M, Tejero J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric Oxide. 2016;53:22-34 pubmed publisher
    ..Altogether, our results uncover unexpected properties of zebrafish globins and reveal the pivotal role of cytoglobins in the transition of heme globins from six-coordinate to five-coordinate oxygen carriers and nitrite reductases. ..
  2. Madden P, Babcock M, Vayda M, Cashon R. Structural and kinetic characterization of myoglobins from eurythermal and stenothermal fish species. Comp Biochem Physiol B Biochem Mol Biol. 2004;137:341-50 pubmed
    Teleost myoglobin (Mb) proteins from four fish species inhabiting different temperature environments were used to investigate the relationship between protein function and thermal stability...
  3. van der Meulen T, Schipper H, Van Leeuwen J, Kranenbarg S. Effects of decreased muscle activity on developing axial musculature in nicb107 mutant zebrafish (Danio rerio). J Exp Biol. 2005;208:3675-87 pubmed
    ..In addition, skin stiffness is affected. In conclusion, the lack of muscle fibre activity did not prevent the basal muscle components developing but influenced further organisation and differentiation of these components. ..
  4. Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
    ..Respiratory proteins like hemoglobin or myoglobin bind or store oxygen, thus enhancing its availability to the respiratory chain in the mitochondria...
  5. van der Meulen T, Schipper H, van den Boogaart J, Huising M, Kranenbarg S, Van Leeuwen J. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2006;291:R1040-8 pubmed
    ..An improvement in aerobic muscle performance was supported by an increase in myoglobin expression...
  6. Roesner A, Mitz S, Hankeln T, Burmester T. Globins and hypoxia adaptation in the goldfish, Carassius auratus. FEBS J. 2008;275:3633-43 pubmed publisher
    ..auratus. We determined the complete coding sequence of hemoglobin alpha and beta and myoglobin, as well as partial cDNAs from neuroglobin and cytoglobin. Like the common carp (Cyprinus carpio), C...
  7. Cossins A, Williams D, Foulkes N, Berenbrink M, Kipar A. Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish. J Exp Biol. 2009;212:627-38 pubmed publisher
    b>Myoglobin (Mb) is famous as a muscle-specific protein--yet the common carp expresses the gene (cMb1) encoding this protein in a range of non-muscle tissues and also expresses a novel isoform (cMb2) in the brain...
  8. Tiedke J, Gerlach F, Mitz S, Hankeln T, Burmester T. Ontogeny of globin expression in zebrafish (Danio rerio). J Comp Physiol B. 2011;181:1011-21 pubmed publisher
    ..The total mRNA levels of the hemoglobin chains, including a newly identified embryonic ?-chain, as well as myoglobin, neuroglobin, cytoglobin 1 and 2, and globin X were estimated...
  9. Blank M, Burmester T. Widespread occurrence of N-terminal acylation in animal globins and possible origin of respiratory globins from a membrane-bound ancestor. Mol Biol Evol. 2012;29:3553-61 pubmed publisher
    ..Vertebrate hemoglobin (Hb), myoglobin, cytoglobin, globin E, and globin Y form a strongly supported common clade, which is the sister group of a clade ..

More Information


  1. Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
    ..Surprisingly, the globins were found to be among the most prominent stress-responsive proteins in our study. Myoglobin showed the strongest response of all investigated genes in the gills, as confirmed by Western blotting...
  2. Zhao Z, Xu P, Cao D, Kuang Y, Deng H, Zhang Y, et al. Duplication and differentiation of common carp (Cyprinus carpio) myoglobin genes revealed by BAC analysis. Gene. 2014;548:210-6 pubmed publisher
    Two distinct myoglobin (mb) transcripts have been reported in common carp, Cyprinus carpio, which is a hypoxia-tolerant fish living in habitats with greatly fluctuant dissolved oxygen levels...
  3. Jaspers R, Testerink J, Della Gaspera B, Chanoine C, Bagowski C, van der Laarse W. Increased oxidative metabolism and myoglobin expression in zebrafish muscle during chronic hypoxia. Biol Open. 2014;3:718-27 pubmed publisher
    ..cross-sectional area (CSA), succinate dehydrogenase (SDH) activity, capillarization, myonuclear density, myoglobin (Mb) concentration and Mb mRNA expression of high and low oxidative muscle fibres...
  4. Blanco E, Guigo R, Messeguer X. Multiple non-collinear TF-map alignments of promoter regions. BMC Bioinformatics. 2007;8:138 pubmed
    ..We consider this kind of approach can be extremely useful in the future to annotate potential transcription factor binding sites on sets of co-regulated genes from high-throughput expression experiments. ..
  5. Vlecken D, Testerink J, Ott E, Sakalis P, Jaspers R, Bagowski C. A critical role for myoglobin in zebrafish development. Int J Dev Biol. 2009;53:517-24 pubmed publisher
    The globin family, including hemoglobin, myoglobin, neuroglobin and cytoglobin, plays an important role in oxygen storage and delivery...