Gene Symbol: mavs
Description: mitochondrial antiviral signaling protein
Alias: wu:fj20d04, zgc:158392, mitochondrial antiviral-signaling protein
Species: zebrafish

Top Publications

  1. López Muñoz A, Roca F, Sepulcre M, Meseguer J, Mulero V. Zebrafish larvae are unable to mount a protective antiviral response against waterborne infection by spring viremia of carp virus. Dev Comp Immunol. 2010;34:546-52 pubmed publisher
    ..This model, in combination with the powerful gene overexpression and morpholino-mediated knockdown techniques, will help to illuminate the IFN system of teleost fish...
  2. Biacchesi S, LeBerre M, Lamoureux A, Louise Y, Lauret E, Boudinot P, et al. Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses. J Virol. 2009;83:7815-27 pubmed publisher
    ..acid-inducible gene I (RIG-I)-like receptors (RLRs) and their mitochondrial adaptor, the mitochondrial antiviral signaling protein (MAVS), also called IPS-1, VISA, and Cardif, highlights the significance of these molecules in ..
  3. Zhou W, Zhou J, Lv Y, Qu Y, Chi M, Li J, et al. Identification and characterization of MAVS from black carp Mylopharyngodon piceus. Fish Shellfish Immunol. 2015;43:460-8 pubmed publisher
    b>MAVS (mitochondria antiviral signaling protein) plays an important role in the host cellular innate immune response against microbial pathogens...
  4. Zou P, Chang M, Li Y, Xue N, Li J, Chen S, et al. NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-?B, and also MDA5, RIG-I and MAVS. Fish Shellfish Immunol. 2016;55:173-85 pubmed publisher
    ..interaction with a receptor-interaction protein, RIPK2, and RLRs such as MDA5 and RIG-I, as well as the adaptor, MAVS was revealed in fish innate immunity...
  5. Du J, Zhang D, Zhang W, Ouyang G, Wang J, Liu X, et al. pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation. J Immunol. 2015;195:1782-90 pubmed publisher
    ..innate antiviral immunity, which acts mainly by inducing degradation of mitochondrial antiviral-signaling protein (MAVS, also known as Cardif, IPS-1, or VISA)...
  6. Palha N, Guivel Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, et al. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013;9:e1003619 pubmed publisher
    ..Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus. ..
  7. Zou P, Chang M, Xue N, Liu X, Li J, Fu J, et al. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 2014;141:192-202 pubmed publisher
    ..the shorter spliced form, MDA5b when co-transfected with MDA5a or mitochondrial antiviral signalling protein (MAVS), induced a significantly higher level of interferon promoter activity, indicating that MDA5b may function as an ..
  8. Chen W, Hu Y, Zou P, Ren S, Nie P, Chang M. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015;49:19-30 pubmed publisher
    The mitochondrial antiviral signaling protein (MAVS) plays a key role in the signal transduction of RIG-I-like receptors (RLRs)-mediated antiviral response...
  9. Zou P, Chang M, Li Y, Huan Zhang S, Fu J, Chen S, et al. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish Shellfish Immunol. 2015;43:13-24 pubmed publisher was revealed that both RIG-Ia and RIG-Ib were associated with the downstream molecular mitochondrial antiviral signaling protein, MAVS, and interestingly RIG-Ia when co-transfected with RIG-Ib or MAVS, induced a significantly ..

More Information


  1. Liu X, Cai X, Zhang D, Xu C, Xiao W. Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. J Immunol. 2016;197:4736-4749 pubmed
    ..Our findings suggest that by suppressing irf3/irf7 activity, zebrafish foxo3b negatively regulates the antiviral response, implicating the vital role of the FOXO gene family in innate immunity. ..
  2. Li S, Lu L, LaPatra S, Chen D, Zhang Y. Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Dev Comp Immunol. 2017;67:189-201 pubmed publisher
    ..These results indicate that fish STAT6 can attenuate the kinase activity of TBK1, leading to suppression of IFNφ1 expression which may in turn facilitate virus replication. ..
  3. Lu L, Li S, Lu X, LaPatra S, Zhang N, Zhang X, et al. Spring Viremia of Carp Virus N Protein Suppresses Fish IFN?1 Production by Targeting the Mitochondrial Antiviral Signaling Protein. J Immunol. 2016;196:3744-53 pubmed publisher
    ..of spring viremia of carp virus (SVCV) inhibits zebrafish IFN?1 production by degrading the mitochondrial antiviral signaling protein (MAVS)...
  4. Xiong R, Nie L, Xiang L, Shao J. Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution. J Immunol. 2012;188:2653-68 pubmed publisher
    ..critical negative regulator of the TIR domain-containing adapter inducing IFN-?, mitochondrial antiviral signaling (MAVS), and IFN signaling pathways, and it is the first PIAS protein that plays a role in the MAVS-mediated pathway to be ..
  5. Ge R, Zhou Y, Peng R, Wang R, Li M, Zhang Y, et al. Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish. J Virol. 2015;89:7696-706 pubmed publisher
    ..This proof-of-concept study indicates that the zebrafish represents an amenable model for the investigation of cytosolic DNA sensing mechanisms. ..
  6. Li S, Lu L, Wang Z, Chen D, Zhang Y. Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish Shellfish Immunol. 2016;57:262-268 pubmed publisher
    ..In addition, overexpression of IRF6 activated the transcription of isg15, rig-i and mavs of host cells; meanwhile, the transcripts of p, m and n genes of SVCV were significantly declined in IRF6-..
  7. Biacchesi S, Merour E, Lamoureux A, Bernard J, Bremont M. Both STING and MAVS fish orthologs contribute to the induction of interferon mediated by RIG-I. PLoS ONE. 2012;7:e47737 pubmed publisher
    ..RNA sensors, RIG-I-like receptors (RLRs), and their mitochondrial adaptor: the mitochondrial antiviral signaling (MAVS) protein, also called IPS-1, highlight their important role in the induction of IFN at the early stage of a virus ..
  8. Jia P, Jin Y, Chen L, Zhang J, Jia K, Yi M. Molecular characterization and expression analysis of mitochondrial antiviral signaling protein gene in sea perch, Lateolabrax japonicus. Dev Comp Immunol. 2016;55:188-93 pubmed publisher
    The mitochondrial antiviral signaling protein (MAVS) is vital for host defenses against viral infection by inducing expression of type I interferon. Here, the MAVS of sea perch (Lateolabrax japonicus) (LjMAVS) was cloned and analyzed...
  9. Lu L, Li S, Lu X, Zhang Y. Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7. Fish Shellfish Immunol. 2015;45:574-82 pubmed publisher
    ..In this study, we reported that the splicing variant of wildtype MAVS (MAVS_tv1), MAVS_tv2, negatively regulated IRF7-mediated IFN production...