Gene Symbol: mapk8b
Description: mitogen-activated protein kinase 8b
Alias: JNK, JNK1, jnk1a-1, mapk8, zgc:112379, mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, c-Jun N-terminal kinase 1, stress-activated protein kinase JNK1
Species: zebrafish
Products:     mapk8b

Top Publications

  1. Krens S, He S, Spaink H, Snaar Jagalska B. Characterization and expression patterns of the MAPK family in zebrafish. Gene Expr Patterns. 2006;6:1019-26 pubmed
    ..In this study we annotated and cloned members of the zebrafish MAPK gene-family, containing the ERK, JNK and p38 subfamilies...
  2. Zhang Y, Bai X, Zhu K, Jin Y, Deng M, Le H, et al. In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury. J Immunol. 2008;181:2155-64 pubmed
    ..Mechanistically, the specific inhibition of JNK, but not p38 and ERK, dramatically abolished the chemotactic migration in a dose-dependent manner, suppressing the ..
  3. Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, et al. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J Cell Biochem. 2010;110:1022-37 pubmed publisher
    Stress-induced Sapk/Jnk signaling is involved in cell survival and apoptosis. Recent studies have increased our understanding of the physiological roles of Jnk signaling in embryonic development...
  4. Rui Y, Xu Z, Xiong B, Cao Y, Lin S, Zhang M, et al. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell. 2007;13:268-82 pubmed
    Axin is a scaffold protein that controls multiple important pathways, including the canonical Wnt pathway and JNK signaling...
  5. Qi M, Dang Y, Xu Q, Yu L, Liu C, Yuan Y, et al. Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response. Chemosphere. 2016;157:166-73 pubmed publisher
    ..Protein expression examined by western blot indicated that MC-LR could activate MAPK8/Bcl-2/Bax pathway and caspase-dependent apoptotic pathway in zebrafish larva and the effects were mitigated by ..
  6. Xiao Y, Zhou Y, Xiong Z, Zou L, Jiang M, Luo Z, et al. Involvement of JNK in the embryonic development and organogenesis in zebrafish. Mar Biotechnol (NY). 2013;15:716-25 pubmed publisher
    ..In this article, it is further revealed that the jnk1 gene is closely related with the embryonic development and organogenesis in zebrafish...
  7. Amali A, Rekha R, Lin C, Wang W, Gong H, Her G, et al. Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. J Biomed Sci. 2006;13:225-32 pubmed
    ..observed to be associated with the up-regulation of apoptotic genes such as, bad, bax, P-38a, caspase-3 and 8, and JNK-1...
  8. Zhong H, Zou H, Semenov M, Moshinsky D, He X, Huang H, et al. Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Mol Biosyst. 2009;5:1356-60 pubmed publisher
    ..Together, 3F8 and its derivatives could be useful as new reagents and potential therapeutic candidates for GSK3 related diseases. ..
  9. Cai C, Lin J, Sun S, He Y. JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development. Front Cell Neurosci. 2016;10:19 pubmed publisher
    b>JNK signaling is known to play a role in regulating cell behaviors such as cell cycle progression, cell proliferation, and apoptosis, and recent studies have suggested important roles for JNK signaling in embryonic development...

More Information


  1. Yang S, Liu S, Ren Z, Jiao X, Qin S. Induction of oxidative stress and related transcriptional effects of perfluorononanoic acid using an in vivo assessment. Comp Biochem Physiol C Toxicol Pharmacol. 2014;160:60-5 pubmed publisher
    ..The expression of p53, apoptosis-inducing factor (AIF) and c-Jun NH (2)-terminal kinase (JNK) was partially increased, while Bcl-2, an anti-apoptotic gene, was reduced, with no significant effects on Bax and ..
  2. Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
    ..These findings agree with the role of globins in oxidative energy metabolism, but may also hint at a specific function in antioxidative defense. ..
  3. Chen J, Tanguay R, Xiao Y, Haggard D, Ge X, Jia Y, et al. TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. Environ Pollut. 2016;216:53-63 pubmed publisher
    ..In summary, TBBPA exposure during a narrow, sensitive developmental window perturbs various molecular pathways and results in neurobehavioral deficits in zebrafish. ..
  4. Li L, Huang T, Tian C, Xiao Y, Kou S, Zhou X, et al. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-?B pathway in zebrafish embryos. Life Sci. 2016;157:97-106 pubmed publisher
    ..Moreover, the PHE also ameliorated the ROS-mediated inflammatory response. ..
  5. Shen L, Zhu J, Chen F, Lin W, Cai J, Zhong J, et al. RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. BMC Cancer. 2015;15:970 pubmed publisher
    ..but also suppressed transforming growth factor β, Jak-STAT, DNA replication, mismatch repair, p53 pathway, JNK signaling pathway, and nucleotide excision repair...
  6. Drerup C, Nechiporuk A. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. PLoS Genet. 2013;9:e1003303 pubmed publisher
    ..Using forward genetics and a novel in vivo imaging approach, we identified JNK-interacting protein 3 (Jip3) as a direct mediator of dynein-based retrograde transport of activated (phosphorylated)..
  7. Fujii R, Yamashita S, Hibi M, Hirano T. Asymmetric p38 activation in zebrafish: its possible role in symmetric and synchronous cleavage. J Cell Biol. 2000;150:1335-48 pubmed
    ..Our findings suggest that asymmetric p38 activation is required for symmetric and synchronous cleavage, and may be regulated by the same machinery that controls the initiation of dorsalizing signals...
  8. Stengel R, Rivera Milla E, Sahoo N, Ebert C, Bollig F, Heinemann S, et al. Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. J Biol Chem. 2012;287:35565-75 pubmed publisher
    ..These results reveal an unanticipated basic activity of kcnh1 that is crucial for early embryonic development and patterning. ..
  9. Shi X, Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci. 2010;115:391-400 pubmed publisher
    ..gene expression profiles of extracellular signal-regulated protein kinase (ERK), c-Jun NH (2)-terminal kinase (JNK), and p38...
  10. Hendricks M, Jesuthasan S. PHR regulates growth cone pausing at intermediate targets through microtubule disassembly. J Neurosci. 2009;29:6593-8 pubmed publisher
    ..By live imaging, we show that loops form when microtubules retract without depolymerizing. JNK, but not p38, phosphorylation is increased in mutant growth cones...
  11. Hu Y, Ma H, Zou Z, He K, Xiao Y, Wang Y, et al. Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress. Biomed Pharmacother. 2017;85:313-322 pubmed publisher
    ..Moreover, as the upstream signalings of Nrf2, the protein kinase B (Akt) and c-Jun NH2-terminal kinase (JNK) signalings were also induced by COP...
  12. Taylor H, Liepe J, Barthen C, Bugeon L, Huvet M, Kirk P, et al. P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish. Immunol Cell Biol. 2013;91:60-9 pubmed publisher
    ..This example shows the high level of information content, which can be gained from live-imaging data if appropriate statistical tools are used. ..