Gene Symbol: mapk14b
Description: mitogen-activated protein kinase 14b
Alias: MAPK14, p38b, zp38b, mitogen-activated protein kinase 14B, MAP kinase 14B, MAP kinase p38b, MAPK 14B, mitogen-activated protein kinase p38b
Shi X, Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci. 2010;115:391-400 pubmed publisher
..Furthermore, we showed that morpholino-mediated knockdown of Nrf2 reduced PFOS-induced HO-1 gene expression. These findings demonstrate that Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae. ..
Lyche J, Nourizadeh Lillabadi R, Karlsson C, Stavik B, Berg V, Skåre J, et al
. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Aquat Toxicol. 2011;102:197-204 pubmed publisher
Chen S, Yu M, Chu X, Li W, Yin X, Chen L. Cold-induced retrotransposition of fish LINEs. J Genet Genomics. 2017;44:385-394 pubmed publisher
..The findings reveal an important function of LINEs in temperature adaptation and provid insights into the MAPK/p38 stress responsive pathway that shapes LINE composition in fishes facing cold stresses. ..
Fujii R, Yamashita S, Hibi M, Hirano T. Asymmetric p38 activation in zebrafish: its possible role in symmetric and synchronous cleavage. J Cell Biol. 2000;150:1335-48 pubmed
..Our findings suggest that asymmetric p38 activation is required for symmetric and synchronous cleavage, and may be regulated by the same machinery that controls the initiation of dorsalizing signals...
Krens S, He S, Spaink H, Snaar Jagalska B. Characterization and expression patterns of the MAPK family in zebrafish. Gene Expr Patterns. 2006;6:1019-26 pubmed
..Erk2,3 and p38a were expressed at a constant level throughout zebrafish embryogenesis, whereas erk1,4,5,6,7 and p38b showed specific temporal expression patterns...
Weiner A, Scampoli N, Calcaterra N. Fishing the molecular bases of Treacher Collins syndrome. PLoS ONE. 2012;7:e29574 pubmed publisher
..This experimental condition may facilitate the study of the disease etiology during embryonic development. ..
Mukhopadhyay D, Priya P, Chattopadhyay A. Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1. Environ Toxicol Pharmacol. 2015;40:352-9 pubmed publisher
..Nrf2/Keap1 proteins had similar expression pattern as their corresponding mRNA. The findings in this study might help to understand the molecular mechanism of fluoride induced neurotoxicity in fish. ..
Lyche J, Nourizadeh Lillabadi R, Almaas C, Stavik B, Berg V, Skåre J, et al
. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. J Toxicol Environ Health A. 2010;73:1032-57 pubmed publisher
..The effects observed in the experimental zebrafish model raise the question whether chemical pollution represents a risk to reproductive health of wild fish inhabitating the freshwater system. ..