Gene Symbol: mapk14a
Description: mitogen-activated protein kinase 14a
Alias: MAPK14, fk28c03, hm:zeh1243, p38, p38a, wu:fk28c03, zp38a, mitogen-activated protein kinase 14A, MAP kinase 14A, MAP kinase p38a, MAPK 14A, etID18993.8, mitogen-activated protein kinase p38a, zeh1243
Species: zebrafish
Products:     mapk14a

Top Publications

  1. Krens S, He S, Spaink H, Snaar Jagalska B. Characterization and expression patterns of the MAPK family in zebrafish. Gene Expr Patterns. 2006;6:1019-26 pubmed
    ..Erk2,3 and p38a were expressed at a constant level throughout zebrafish embryogenesis, whereas erk1,4,5,6,7 and p38b showed ..
  2. Hsu R, Lin C, Su Y, Tsai H. dickkopf-3-related gene regulates the expression of zebrafish myf5 gene through phosphorylated p38a-dependent Smad4 activity. J Biol Chem. 2011;286:6855-64 pubmed publisher
    ..dkk3r-specific morpholino-oligonucleotide (dkk3r-MO) to knock down Dkk3r, we found that the phosphorylated p38a protein was reduced...
  3. Fujii R, Yamashita S, Hibi M, Hirano T. Asymmetric p38 activation in zebrafish: its possible role in symmetric and synchronous cleavage. J Cell Biol. 2000;150:1335-48 pubmed
    ..We showed that p38 MAP kinase (p38) is asymmetrically activated on one side of the blastodisc during the early cleavage period in ..
  4. Taylor H, Liepe J, Barthen C, Bugeon L, Huvet M, Kirk P, et al. P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish. Immunol Cell Biol. 2013;91:60-9 pubmed publisher
    ..We then use pharmacological inhibition of p38 and c-Jun N-terminal kinase mitogen-activated protein kinases to determine their effects on in vivo leukocyte ..
  5. Mottaz H, Schönenberger R, Fischer S, Eggen R, Schirmer K, Groh K. Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish. Environ Pollut. 2017;221:105-115 pubmed publisher
    ..immunosuppression, reflected in downregulation of several inflammation-related genes, including myd88, trif, traf6, p38, nf?b2, il-1?, il-8 and ccl34a. Fish exposed to 1 mg/L MO accumulated 11...
  6. Holloway B, Gomez de la Torre Canny S, Ye Y, Slusarski D, Freisinger C, Dosch R, et al. A novel role for MAPKAPK2 in morphogenesis during zebrafish development. PLoS Genet. 2009;5:e1000413 pubmed publisher
    ..We show that the regulation of MAPKAPK2 is conserved and p38 MAP kinase functions upstream of MAPKAPK2 in regulating epiboly in the zebrafish embryo...
  7. Hu Y, Ma H, Zou Z, He K, Xiao Y, Wang Y, et al. Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress. Biomed Pharmacother. 2017;85:313-322 pubmed publisher
    ..And up-regulating Nrf2-mediated NQO1 expression of COP was in Akt and JNK-dependent manner. Taken together, COP exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway. ..
  8. Shi X, Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci. 2010;115:391-400 pubmed publisher
    ..expression profiles of extracellular signal-regulated protein kinase (ERK), c-Jun NH (2)-terminal kinase (JNK), and p38. The ERK gene expression levels were unchanged, whereas JNK and p38 gene expressions were significantly upregulated,..
  9. Sheng L, Wang L, Su M, Zhao X, Hu R, Yu X, et al. Mechanism of TiO2 nanoparticle-induced neurotoxicity in zebrafish (Danio rerio). Environ Toxicol. 2016;31:163-75 pubmed publisher
    ..of TiO2 NPs significantly activated expressions of C-fos, C-jun, and BDNF genes, and suppressed expressions of p38, NGF, CREB, NR1, NR2ab, and GluR2 genes...

More Information


  1. Stengel R, Rivera Milla E, Sahoo N, Ebert C, Bollig F, Heinemann S, et al. Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. J Biol Chem. 2012;287:35565-75 pubmed publisher
    ..These results reveal an unanticipated basic activity of kcnh1 that is crucial for early embryonic development and patterning. ..
  2. Hidasi A, Groh K, Suter M, Schirmer K. Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations. Ecotoxicol Environ Saf. 2017;138:16-24 pubmed publisher
    ..This may reduce the chances of fish to survive in the environment, as their defense against pathogens is weakened. ..
  3. Li L, Huang T, Tian C, Xiao Y, Kou S, Zhou X, et al. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-?B pathway in zebrafish embryos. Life Sci. 2016;157:97-106 pubmed publisher
    ..Moreover, the PHE also ameliorated the ROS-mediated inflammatory response. ..
  4. Campbell D, Okamoto H. Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization. J Cell Biol. 2013;203:657-72 pubmed publisher
    ..Caspase activation, dependent on Caspase-3, Caspase-9, and p38 mitogen-activated protein kinase (MAPK), rapidly increased at branch points corresponding with branch tip addition...
  5. Sanden M, Jørgensen S, Hemre G, Ørnsrud R, Sissener N. Zebrafish (Danio rerio) as a model for investigating dietary toxic effects of deoxynivalenol contamination in aquaculture feeds. Food Chem Toxicol. 2012;50:4441-8 pubmed publisher
    ..We do not know if effects observed on fecundity and larvae swimming activity are attributed to a direct interaction of DON with the reproductive organ or secondary to the maternal/paternal liver oxidative imbalance. ..
  6. Jopling C, Suñé G, Morera C, Izpisua Belmonte J. p38? MAPK regulates myocardial regeneration in zebrafish. Cell Cycle. 2012;11:1195-201 pubmed publisher
    ..b>p38? ?APK has previously been shown to negatively regulate the proliferation of adult mammalian cardiomyocytes...
  7. YONKERS M, Ribera A. Molecular components underlying nongenomic thyroid hormone signaling in embryonic zebrafish neurons. Neural Dev. 2009;4:20 pubmed publisher
    ..We found that pharmacological blockade of protein phosphatase 1 and the mitogen-activated protein kinase p38 isoform decreased and increased tonic sodium current amplitudes, respectively, and blockade of either occluded ..
  8. Amali A, Rekha R, Lin C, Wang W, Gong H, Her G, et al. Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. J Biomed Sci. 2006;13:225-32 pubmed
    ..Moreover, non-availability of specific drugs to prevent steatohepatitis, this animal model may serve as a powerful preclinical platform to study the therapeutic strategies and for evaluating chemoprevention strategies for this disease...
  9. Encinas P, Garcia Valtanen P, Chinchilla B, Gomez Casado E, Estepa A, Coll J. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. PLoS ONE. 2013;8:e73553 pubmed publisher
    ..These results could contribute to develop novel drug-based prevention methods and consolidate the zebrafish/SVCV as a model for vertebrate viral diseases. ..
  10. Shen Q, Little S, Xu M, Haupt J, Ast C, Katagiri T, et al. The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J Clin Invest. 2009;119:3462-72 pubmed publisher
  11. Hendricks M, Jesuthasan S. PHR regulates growth cone pausing at intermediate targets through microtubule disassembly. J Neurosci. 2009;29:6593-8 pubmed publisher
    ..phr mutants contain excessive microtubules in the growth cone, which has been attributed to upregulation of DLK/p38 signaling...