Gene Symbol: mapk1
Description: mitogen-activated protein kinase 1
Alias: zERK2, mitogen-activated protein kinase 1, ERK2
Species: zebrafish
Products:     mapk1

Top Publications

  1. Le H, Zhang Y, Liu H, Ma L, Jin Y, Huang Q, et al. eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish. J Biol Chem. 2008;283:17652-61 pubmed publisher
    ..The results suggest that eena plays an important role in the development of the myeloid cell through activation of the ERK pathway and may provide a valuable reference for future studies of the role of EEN in leukemogenesis. ..
  2. Krens S, He S, Lamers G, Meijer A, Bakkers J, Schmidt T, et al. Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Dev Biol. 2008;319:370-83 pubmed publisher
    ..Here we define differential functions for ERK1 and ERK2 MAPKs in zebrafish embryogenesis...
  3. Michailidou C, Jones M, Walker P, Kamarashev J, Kelly A, Hurlstone A. Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Dis Model Mech. 2009;2:399-411 pubmed publisher
  4. Shen K, Sidik H, Talbot W. The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. Cell Rep. 2016;14:547-559 pubmed publisher
    ..Our analysis reveals an essential role of the Rag-Ragulator complex in proper lysosome function and phagocytic flux in microglia. ..
  5. Keller J, Escara Wilke J, Keller E. Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells. Comp Biochem Physiol A Mol Integr Physiol. 2008;150:307-14 pubmed publisher
    ..Heat stress induced both Hsp70 mRNA expression and phosphorylation of both ERK1 and ERK2 (ERK1/2) in Pac2 cells...
  6. Zhong H, Zou H, Semenov M, Moshinsky D, He X, Huang H, et al. Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Mol Biosyst. 2009;5:1356-60 pubmed publisher
    ..Together, 3F8 and its derivatives could be useful as new reagents and potential therapeutic candidates for GSK3 related diseases. ..
  7. Snaar Jagalska B, Krens S, Robina I, Wang L, Spaink H. Specific activation of ERK pathways by chitin oligosaccharides in embryonic zebrafish cell lines. Glycobiology. 2003;13:725-32 pubmed
    ..We conclude that a high-affinity CO receptor system exists that links to the Raf, MEK, and ERK pathway in zebrafish cells. ..
  8. Ren B, Deng Y, Mukhopadhyay A, Lanahan A, Zhuang Z, Moodie K, et al. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. J Clin Invest. 2010;120:1217-28 pubmed publisher
    ..We therefore conclude that PI3K-ERK1/2 crosstalk plays a key role in the regulation of arterial growth and that the augmentation of ERK signaling via suppression of the PI3K signaling pathway can effectively stimulate arteriogenesis. ..
  9. Stengel R, Rivera Milla E, Sahoo N, Ebert C, Bollig F, Heinemann S, et al. Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. J Biol Chem. 2012;287:35565-75 pubmed publisher
    ..These results reveal an unanticipated basic activity of kcnh1 that is crucial for early embryonic development and patterning. ..

More Information


  1. Shi X, Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci. 2010;115:391-400 pubmed publisher
    ..Furthermore, we showed that morpholino-mediated knockdown of Nrf2 reduced PFOS-induced HO-1 gene expression. These findings demonstrate that Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae. ..
  2. Liu P, Zhong T. MAPK/ERK signalling is required for zebrafish cardiac regeneration. Biotechnol Lett. 2017;39:1069-1077 pubmed publisher
    ..Appropriate activation of MAPK/ERK signalling is essential for zebrafish cardiac regeneration. ..
  3. Hu Y, Ma H, Zou Z, He K, Xiao Y, Wang Y, et al. Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress. Biomed Pharmacother. 2017;85:313-322 pubmed publisher
    ..And up-regulating Nrf2-mediated NQO1 expression of COP was in Akt and JNK-dependent manner. Taken together, COP exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway. ..
  4. Li L, Huang T, Tian C, Xiao Y, Kou S, Zhou X, et al. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-?B pathway in zebrafish embryos. Life Sci. 2016;157:97-106 pubmed publisher
    ..Moreover, the PHE also ameliorated the ROS-mediated inflammatory response. ..
  5. Li C, Ma H, Wang Y, Cao Z, Graves Deal R, Powell A, et al. Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J Clin Invest. 2014;124:2172-87 pubmed
    ..PLAC8-induced EMT was linked to increased phosphorylated ERK2 (p-ERK2), and ERK2 knockdown restored cell surface CDH1 and suppressed CDH3, VIM, and ZEB1 upregulation...
  6. Pan C, Wu J, Hui C, Lin C, Chen J. Insights into the antibacterial and immunomodulatory functions of the antimicrobial peptide, epinecidin-1, against Vibrio vulnificus infection in zebrafish. Fish Shellfish Immunol. 2011;31:1019-25 pubmed publisher
    ..This study demonstrates the use of epinecidin-1 to develop inactivated material for fish bacterial infections which can provide guidelines for the future design of epinecidin-1-bacterial formulations for various in vivo applications. ..
  7. Lee Y, Park Y, Choi W, Park E, Lee E, Lee J, et al. Sequence and expression analysis of extracellular signal-regulated kinase 1 from flounder (Paralichthys olivaceous). Fish Shellfish Immunol. 2010;28:65-71 pubmed publisher
    ..Flounder MAPK was successfully expressed in mammalian COS1 cells and phosphorylated myelin basic protein (MBP) substrate when the cells were stimulated with PMA or EGF, indicating that flounder MAPK is functional in animal cells. ..
  8. Krens S, He S, Spaink H, Snaar Jagalska B. Characterization and expression patterns of the MAPK family in zebrafish. Gene Expr Patterns. 2006;6:1019-26 pubmed
    ..b>Erk2,3 and p38a were expressed at a constant level throughout zebrafish embryogenesis, whereas erk1,4,5,6,7 and p38b ..