Genomes and Genes
Gene Symbol: ltk
Description: leukocyte receptor tyrosine kinase
Alias: ALK, TYK1, si:dz107o16.1, leukocyte tyrosine kinase receptor, anaplastic lymphoma kinase, leukocyte tyrosine kinase, shd(l)
- Irion U, FrohnhÃ¶fer H, Krauss J, Ã‡olak Champollion T, Maischein H, Geiger Rudolph S, et al. Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish. elife. 2014;3:e05125 pubmed publisher..The phenotypes indicate that these promote homotypic interactions between melanophores and xanthophores, respectively, and those cells instruct the patterning of the iridophores. ..
- Mo E, Cheng Q, Reshetnyak A, Schlessinger J, Nicoli S. Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk. Proc Natl Acad Sci U S A. 2017;114:12027-12032 pubmed publisherb>Anaplastic lymphoma kinase (Alk) and leucocyte tyrosine kinase (Ltk) were identified as "orphan" receptor tyrosine kinases (RTKs) with oncogenic potential...
- Rodrigues F, Yang X, Nikaido M, Liu Q, Kelsh R. A simple, highly visual in vivo screen for anaplastic lymphoma kinase inhibitors. ACS Chem Biol. 2012;7:1968-74 pubmed publisherb>Anaplastic lymphoma kinase (ALK) is an important drug target in many cancers, including lymphoma, neuroblastoma, and lung cancer...
- Fadeev A, Krauss J, Singh A, NÃ¼sslein Volhard C. Zebrafish Leucocyte tyrosine kinase controls iridophore establishment, proliferation and survival. Pigment Cell Melanoma Res. 2016;29:284-96 pubmed publisher..Using gain- and loss-of-function alleles of leucocyte tyrosine kinase (ltk) and a pharmacological inhibitor approach, we show that Ltk specifically regulates iridophore establishment, ..