Gene Symbol: lrp6
Description: low density lipoprotein receptor-related protein 6
Alias: low-density lipoprotein receptor-related protein 6
Kagermeier Schenk B, Wehner D, Ozhan Kizil G, Yamamoto H, Li J, Kirchner K, et al
. Waif1/5T4 inhibits Wnt/?-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. Dev Cell. 2011;21:1129-43 pubmed publisher
..Waif1a binds to the Wnt coreceptor LRP6 and inhibits Wnt-induced LRP6 internalization into endocytic vesicles, a process that is required for pathway ..
Jiang Y, He X, Howe P. Disabled-2 (Dab2) inhibits Wnt/?-catenin signalling by binding LRP6 and promoting its internalization through clathrin. EMBO J. 2012;31:2336-49 pubmed publisher
..Wnt signalling requires caveolin-dependent internalization of low-density lipoprotein receptor-related protein 6 (LRP6)...
McGraw H, Culbertson M, Nechiporuk A. Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish. Development. 2014;141:3212-21 pubmed publisher
..Based on our data, we propose a novel mechanism in which Kremen1 modulates Wnt activity by restricting the range of secreted Dkk proteins during collective cell migration in the pLLP. ..
Reading B, Hiramatsu N, Schilling J, Molloy K, Glassbrook N, Mizuta H, et al
. Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenins in teleost fishes. J Lipid Res. 2014;55:2287-95 pubmed publisher
..The presence of lrp13 orthologs in mammals suggests that this lipoprotein receptor is widely distributed among vertebrates, where it may generally play a role in lipoprotein metabolism. ..
Larraguibel J, Weiss A, Pasula D, Dhaliwal R, Kondra R, Van Raay T. Wnt ligand-dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell. 2015;26:2375-84 pubmed publisher
..Comparison of these results with Nkd function in Drosophila generates a unified and conserved model for the role of this negative feedback regulator in the modulation of Wnt signaling. ..
Mathew L, Sengupta S, Ladu J, Andreasen E, Tanguay R. Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB J. 2008;22:3087-96 pubmed publisher
..Because R-Spondin1 signals through the Wnt coreceptor LRP6, we further demonstrated that the TCDD-mediated block in regeneration is also LRP6 dependent...
Chen M, Philipp M, Wang J, Premont R, Garrison T, Caron M, et al
. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J Biol Chem. 2009;284:35040-8 pubmed publisher
..Subsequently, phosphorylation of serine/threonine residues within five repeating signature PPPSP motifs on LRP6 is responsible for LRP6 activation...
Zhong H, Zou H, Semenov M, Moshinsky D, He X, Huang H, et al
. Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Mol Biosyst. 2009;5:1356-60 pubmed publisher
..Together, 3F8 and its derivatives could be useful as new reagents and potential therapeutic candidates for GSK3 related diseases. ..